Guowen Liu
Jilin University
Internal medicineEndocrinologyProinflammatory cytokineChemistryIn vitroOxidative stressKetosisFatty liverNEFALipid metabolismFatty acid synthaseFatty acidBiochemistryOxidative phosphorylationSignal transductionVery low-density lipoproteinBiologyCell biologyProtein kinase APharmacology
129Publications
27H-index
2,279Citations
Publications 123
Newest
#1Qinghua Deng (IMUN: Inner Mongolia University for Nationalities)H-Index: 1
#1Qinghua Deng (IMUN: Inner Mongolia University for Nationalities)H-Index: 8
Last. Guowen Liu (IMUN: Inner Mongolia University for Nationalities)H-Index: 27
view all 6 authors...
: Dairy cows with fatty liver or ketosis display decreased insulin sensitivity and defects in the insulin receptor substrate (IRS)/PI3K/AKT signaling pathway. Phosphatase and tensin homolog (PTEN) is a well-known tumor suppressor and also a negative regulator of insulin signaling and peripheral insulin sensitivity. We investigated the hypothesis that PTEN may affect the insulin pathway-mediated hepatic glucose and lipid metabolism in dairy cows. Adenovirus vectors that over-express and silence P...
4 CitationsSource
#1Xudong Sun (JLU: Jilin University)H-Index: 7
#2Yazhe Wang (JLU: Jilin University)H-Index: 6
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 11 authors...
ABSTRACT High blood concentrations of nonesterified fatty acids (NEFA) during ketosis represent a source of fatty acids for milk fat synthesis and explain the increase in milk fat content in ketotic cows. Cell death-inducing DFFA-like effector a (CIDEA) is a lipid droplet coat protein with important roles in the regulation of milk fat synthesis and secretion in mice. Whether ketosis alters the expression of CIDEA in mammary gland tissue and the extent to which it may contribute to regulation of ...
13 CitationsSource
#1Qiushi Xu (JLU: Jilin University)H-Index: 6
#2Hongdou Jia (JLU: Jilin University)H-Index: 7
Last. Xiaobing Li (JLU: Jilin University)H-Index: 22
view all 8 authors...
Dairy cows with metabolic disorder in peripartal period display high inflammatory levels. Adipose tissue is a major endocrine organ, which is closely related to systemic inflammation. Retinoic acid (RA), an active metabolite of vitamin A, has shown potential therapeutic immunomodulatory properties. The objective of the study was to examine the effect of all-trans-RA (ATRA), the biologically most active metabolite of vitamin A, on lipopolysaccharide (LPS)-induced bovine adipocytes inflammatory re...
9 CitationsSource
#1Hongdou Jia (JLU: Jilin University)H-Index: 7
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 13 authors...
ABSTRACT Fatty liver is a common metabolic disorder in dairy cows during the transition period. Perilipin 5 (PLIN5), a lipid droplet coat protein, plays important roles in the development of hepatic steatosis in mice and humans. Whether PLIN5 plays a role in the development of fatty liver in dairy cows is unknown. An in vivo study consisting of 10 healthy and 10 cows with fatty liver was performed to harvest liver tissue and blood samples. In addition, hepatocytes isolated from calves were infec...
11 CitationsSource
#1Zhicheng Peng (JLU: Jilin University)H-Index: 9
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 7 authors...
: The NOD‑like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been reported to contribute to palmitic acid (PA)‑induced lipotoxicity. Nobiletin (Nob) is a polymethoxylated flavonoid derived from citrus fruits that has been reported to exert antioxidant and antitumor effects. However, its protective and regulatory mechanisms in PA‑induced lipotoxicity remain unclear. Therefore, the aim of the present study was to investigate the protective effects of Nob in AML‑12 cells agains...
5 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Taiyu Shen (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation of the hepatic metabolism to overcome metabolic stress. Fatty liver is one of the main health disorders after parturition. Therefore, to investigate changes in hepatic lipid metabolic status and mitochondria in dairy cows with mild fatty liver, liver and blood samples were collected from healthy cows (n = 15) and cows with mild fatty liver (n = 15). To determine the effects of palm...
37 CitationsSource
#1Jianguo Wang (NWAFU: Northwest A&F University)H-Index: 10
#2Xiaoyan Zhu (NWAFU: Northwest A&F University)H-Index: 8
Last. Baoyu Zhao (NWAFU: Northwest A&F University)H-Index: 5
view all 8 authors...
During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important roles in lipid metabolism. The purposes of our study were to evaluate variations of serum ANGPTL4 and FGF21 concentrations in periparturient dairy cows and changes in these serum analyte concentrations of energy-related metabolic disorders in early lactation d...
8 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Guowen LiuH-Index: 27
view all 11 authors...
: Insulin resistance is often characterized as the most critical factor contributing to the development of (T2D) type 2 diabetes. MicroRNAs (miRNAs) are endogenous non-coding short single-stranded RNAs that function as negative regulators in many physiological and pathological processes. The objective of this study was to evaluate the roles of miR-125b in the regulation of insulin sensitivity in hepatocytes. We found that hepatic miR-125b levels were significantly increased in the patients with ...
9 CitationsSource
#1Wenwen Gao (JLU: Jilin University)H-Index: 5
#2Xiliang Du (JLU: Jilin University)H-Index: 12
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 9 authors...
: The aim of this study was to investigate the changes in hepatic oxidative phosphorylation (OXPHOS) complexes (COs) in patients and cows with non-alcoholic steatohepatitis (NASH) and to investigate the mechanism that links mitochondrial dysfunction and hepatic insulin resistance induced by non-esterified fatty acids (NEFAs). Patients and cows with NASH displayed high blood NEFAs, TNF-α and IL-6 concentrations, mitochondrial dysfunction and insulin resistance. The protein levels of peroxisome pr...
29 CitationsSource
#1Wei YangH-Index: 1
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xu ChuangH-Index: 1
view all 7 authors...
Background: As a frequent subclinical disease, fatty liver disease (FLD) is associated with a severe negative energy balance (NEB) during the early lactation period, and usually cause of economic loss to dairy farmers. Liver biopsy is the gold standard for the assessment of FLD. However, as an invasive procedure, liver biopsy has several limitations and such procedures are not readily available to dairy farmers. To further evaluate FLD in dairy cows, a FLD model of lactating sheep was developed ...
2 CitationsSource