Shoupeng Fu
Jilin University
PhosphorylationInternal medicineEndocrinologyDopaminergicChemistryIn vivoNeuroprotectionInflammationNF-?BLipopolysaccharideMicrogliaAMPKSubstantia nigrap38 mitogen-activated protein kinasesSignal transductionProtein kinase BPI3K/AKT/mTOR pathwayBiologyNeuroinflammationCell biologyPharmacology
60Publications
19H-index
928Citations
Publications 62
Newest
#1Yuanxi Yang (JLU: Jilin University)
#2Xin Ran (JLU: Jilin University)H-Index: 9
Last. Wenjin Guo (JLU: Jilin University)H-Index: 10
view all 10 authors...
Evodiamine, an alkaloid component in the fruit of Evodia, has been shown to have biological functions such as antioxidant and anti-inflammatory. But whether evodiamine plays an improvement role on mastitis has not been studied. To investigate the effect and mechanism of evodiamine on lipopolysaccharide (LPS)-induced mastitis was the purpose of this study. In animal experiments, the mouse mastitis model was established by injecting LPS into the canals of the mammary gland. The results showed that...
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#1Xingchi Kan (JLU: Jilin University)H-Index: 8
#2Guiqiu Hu (JLU: Jilin University)H-Index: 8
Last. Juxiong Liu (JLU: Jilin University)H-Index: 16
view all 10 authors...
Mastitis is a disease that seriously threatens the health of the mammary gland after delivery. Pedunculoside (PE) is the main bioactive component of Aquifoliaceae. The purpose of this experiment is to explore the effects of PE on mastitis and its underlying mechanisms. Our research results showed that PE could significantly inhibit the increase in the levels of inflammatory mediators such as TNF-α, IL-6, IL-1β, MPO and iNOS during mastitis. Mechanism studies have found that PE could significantl...
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#1Xingchi Kan (JLU: Jilin University)H-Index: 8
#2Juxiong Liu (JLU: Jilin University)H-Index: 16
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 9 authors...
The inflammatory reaction of mammary gland tissue in dairy cattle leads to the occurrence of mastitis disease and causes huge economic loss. Myricetin (Myr), a flavonoid natural product, is extracted from the root, stem, and leaves of Myrica rubra. It has a wide range of biological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor. The purpose of this experiment is to further explore the effect of Myr on mastitis and further explore its potential mechanism in LPS-induced mice m...
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#1Yu Cao (JLU: Jilin University)H-Index: 4
#2Guiqiu Hu (JLU: Jilin University)H-Index: 8
Last. Juxiong Liu (JLU: Jilin University)H-Index: 16
view all 11 authors...
Kisspeptin-10 (Kp-10) is a peptide hormone that regulates normal physiological processes. The mechanism of Kp-10 in milk synthesis is still unclear. Therefore, bovine mammary epithelial cells (BMECs) were used to study the mechanism by which Kp-10 affects milk synthesis in BMECs. The GPR54 inhibitor and SIRT6 overexpression plasmid and siRNA were used to study the mechanism of regulating milk protein and milk fat synthesis by Kp-10. The results showed that 100 nM Kp-10 increased milk synthesis i...
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#1Dewei HeH-Index: 9
#2Shoupeng FuH-Index: 19
Last. Dianfeng LiuH-Index: 10
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Microglia, the main immune cells in the brain, participate in the innate immune response in the central nervous system (CNS). Studies have shown that microglia can be polarized into pro-inflammatory M1 and anti-inflammatory M2 phenotypes. Accumulated evidence suggests that over-activated M1 microglia release pro-inflammatory mediators that damage neurons and lead to Parkinson's disease (PD). In contrast, M2 microglia release neuroprotective factors and exert the effects of neuroprotection. Campt...
4 CitationsSource
#1Xingchi Kan (JLU: Jilin University)H-Index: 8
#2Juxiong Liu (JLU: Jilin University)H-Index: 16
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
view all 9 authors...
High-producing dairy cows are prone to oxidative stress due to their high secretion and strong metabolism, and excessive oxidative stress may cause the apoptosis of bovine mammary epithelial cells (bMECs). Myricetin (Myr) has been shown to have a wide range of pharmaceutical activities. The aim of this study was to evaluate the effect of Myr on hydrogen peroxide (H2 O2 )-induced oxidative stress and apoptosis in bMECs and to clarify the underlying mechanism. bMECs were pretreated with or without...
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#1Yu Cao (JLU: Jilin University)H-Index: 4
#2Yan Zhang (JLU: Jilin University)H-Index: 9
Last. Juxiong Liu (JLU: Jilin University)H-Index: 16
view all 9 authors...
Previous studies have shown the effects of vitamins on the development of the mammary gland. However, the role of niacin in this process has not been reported. Therefore, the aim of this study is to investigate the effects of niacin on mammary gland development in pubertal mice and to use a mouse mammary epithelial cell line to study the underlying mechanism. The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways and increase phosphorylation of 4EBP1 to promote the...
1 CitationsSource
#1Wenjin Guo (JLU: Jilin University)H-Index: 10
#2Juxiong Liu (JLU: Jilin University)H-Index: 16
Last. Guiqiu HuH-Index: 8
view all 11 authors...
Abstract Heat stress (HS) in summer will seriously affect the health and performance of dairy cows. To alleviate the injury to dairy cows caused by HS, we added the rumen-bypassed tributyrin to the feed. We determined whether cows were in a heat-stressed environment by testing the temperature humidity index in the morning, at noon, and in the evening. The detection of anal temperature and respiratory frequency further proved the HS state of the dairy cows. The quantificational real time PCR resu...
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#1He Ma (JLU: Jilin University)H-Index: 6
#2Yufei Zhang (JLU: Jilin University)H-Index: 3
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
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Palmatine has a wide range of pharmacological effects and anti-inflammatory function. However, the effect of palmatine on LPS-induced inflammatory response of mammary epithelial cells has not been reported. In this research, we studied the anti-inflammatory mechanism of palmatine in EpH4-Ev (mouse mammary epithelial cells). EpH4-Ev cells were pre-treated with palmatine and then incubated with LPS. Cells were collected for examining production of pro-inflammatory mediators by qRT-PCR, and the rel...
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#1Tianyu Meng (JLU: Jilin University)H-Index: 4
#2Shoupeng Fu (JLU: Jilin University)H-Index: 19
Last. Dianfeng Liu (JLU: Jilin University)H-Index: 10
view all 11 authors...
Neuroinflammation is caused by excessive activation of microglia and plays an essential role in neurodegenerative diseases. After activation, microglia produce several kinds of inflammatory mediators, trigger an excessive inflammatory response, and ultimately destroy the surrounding neurons. Therefore, agents that inhibit neuroinflammation may be potential drug candidates for neurodegenerative diseases. Evodiamine (EV) has anti-inflammatory functions in peripheral tissues. However, whether EV ex...
7 CitationsSource