Wesley K. Thompson
University of California, San Diego
Genome-wide association studyPsychiatryInternal medicineDevelopmental psychologySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationBipolar disorderDiseaseComputer scienceGeneticsNeuroimagingClinical psychologyMedicineCohortBiologyGenetic architecture
Publications 291
#1Kylie P. Glanville ('KCL': King's College London)H-Index: 7
#2Jonathan R.I. Coleman (NIHR: National Institute for Health Research)H-Index: 28
Last. Anders D. BørglumH-Index: 67
view all 208 authors...
Abstract Background The prevalence of depression is higher in individuals suffering from autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the Major Histocompatibility Complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression. Method We fine-mapped the classical MHC (chr6: 29.6...
13 CitationsSource
We present the findings of "The Alzheimer's Disease Prediction Of Longitudinal Evolution" (TADPOLE) Challenge, which compared the performance of 92 algorithms from 33 international teams at predicting the future trajectory of 219 individuals at risk of Alzheimer's disease. Challenge participants were required to make a prediction, for each month of a 5-year future time period, of three key outcomes: clinical diagnosis, Alzheimer's Disease Assessment Scale Cognitive Subdomain (ADAS-Cog13), and to...
10 Citations
#1F. Kyle Satterstrom (Broad Institute)H-Index: 25
#2Jack A. KosmickiH-Index: 25
Last. Mark J. DalyH-Index: 213
view all 190 authors...
Summary We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n=35,584 total samples, 11,986 with ASD). Using an enhanced Bayesian framework to integrate de novo and case-control rare variation, we identify 102 risk genes at a false discovery rate ≤ 0.1. Of these genes, 49 show higher frequencies of disruptive de novo variants in individuals ascertained for severe neurodevelopmental delay, while 53 show higher frequencies in individuals ascertained for ASD; com...
459 CitationsSource
#1Samuel W. Hawes (FIU: Florida International University)H-Index: 21
#2Rebecca Waller (UPenn: University of Pennsylvania)H-Index: 24
Last. Raul Gonzalez (FIU: Florida International University)H-Index: 35
view all 8 authors...
Background Callous-unemotional (CU) traits are critical to developmental, diagnostic, and clinical models of antisocial behaviors (AB). However, assessments of CU traits within large-scale longitudinal and neurobiologically focused investigations remain remarkably sparse. We sought to develop a brief measure of CU traits using items from widely administered instruments that could be linked to neuroimaging, genetic, and environmental data within already existing datasets and future studies. Metho...
8 CitationsSource
#1Sergio Picart-Armada (UPC: Polytechnic University of Catalonia)H-Index: 5
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
Last. Alexandre Perera-Lluna (UPC: Polytechnic University of Catalonia)H-Index: 12
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Motivation: Network diffusion and label propagation are fundamental tools in computational biology, with applications like gene-disease association, protein function prediction and module discovery. More recently, several publications have introduced a permutation analysis after the propagation process, due to concerns that network topology can bias diffusion scores. This opens the question of the statistical properties and the presence of bias of such diffusion processes in each of its applicat...
#1Philip S. Insel (UCSF: University of California, San Francisco)H-Index: 37
#2Elizabeth C. Mormino (Stanford University)H-Index: 50
Last. Michael C. Donohue (SC: University of Southern California)H-Index: 48
view all 5 authors...
With recent advances in our understanding of the continuous pathophysiological changes that begin many years prior to symptom onset, it is now apparent that Alzheimer's disease cannot be adequately described by discrete clinical stages, but should also incorporate the continuum of biological changes that precede and underlie the clinical representation of the disease. By jointly considering longitudinal changes of all available biomarkers and clinical assessments, variation within individuals ca...
22 CitationsSource
#1Olav B. Smeland (Oslo University Hospital)H-Index: 22
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 11 authors...
In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic etiology of complex human traits and disorders. However, a large fraction of the polygenic architecture underlying most complex phenotypes still remains undetected. We here review the conditional false discovery rate (condFDR) method, a model-free strategy for analysis of GW...
30 CitationsSource
Analysis of genome-wide association studies (GWAS) is characterized by a large number of univariate regressions where a quantitative trait is regressed on hundreds of thousands to millions of single-nucleotide polymorphism (SNP) allele counts, one at a time. This article proposes an estimator of the SNP heritability of the trait, defined here as the fraction of the variance of the trait explained by the SNPs in the study. The proposed GWAS heritability (GWASH) estimator is easy to compute, highl...
3 CitationsSource
#1Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
view all 143 authors...
Abstract The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other o...
141 CitationsSource
#1Ron Nudel (Lundbeck)H-Index: 9
#2Yunpeng Wang (Lundbeck)H-Index: 34
Last. Michael Eriksen Benros (Lundbeck)H-Index: 2
view all 16 authors...
Infections and mental disorders are two of the major global disease burdens. While correlations between mental disorders and infections have been reported, the possible genetic links between them have not been assessed in large-scale studies. Moreover, the genetic basis of susceptibility to infection is largely unknown, as large-scale genome-wide association studies of susceptibility to infection have been lacking. We utilized a large Danish population-based sample (N = 65,534) linked to nationw...
15 CitationsSource