Shosaku Nomura
Kansai Medical University
Internal medicineEndocrinologyPathologyOncologyMolecular biologyAntibodyAutoantibodyChemistryImmunologyLung cancerThrombocytopenic purpuraTransplantationIn patientPlatelet activationMonoclonal antibodyFlow cytometryMedicineBiologyPlateletGastroenterology
382Publications
52H-index
5,956Citations
Publications 382
Newest
#1Nobuyasu Ishii (Kansai Medical University)H-Index: 2
#2Toshiki Shimizu (Kansai Medical University)H-Index: 10
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
view all 7 authors...
Background Tocilizumab (TCZ) is humanized monoclonal antibody against the interleukin-6 (IL-6) and receptor that has prominent efficacy for the treatment of rheumatoid arthritis (RA). We conducted a retrospective observational study to determine how long TCZ controls RA. Patients and Methods We retrospectively reviewed the medical records of RA patients treated with TCZ. The aim of this study was to evaluate the contribution of clinical parameters to disease control time (DCT) in RA patients. Re...
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#1Aya Nakaya (Kansai Medical University)H-Index: 8
#1Aya NakayaH-Index: 2
Last. Kazunori ImadaH-Index: 23
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Background null Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by low platelet counts resulting from antiplatelet autoantibodies. Analysis of polymorphisms in cytokine-encoding genes is important for understanding the pathophysiology of ITP and selecting appropriate treatments. We investigated associations between polymorphisms in cytokine-encoding genes and responses to therapy in Japanese patients with ITP. null Methods null The participants in this study comprise...
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#1Masaaki Hotta (Kansai Medical University)H-Index: 6
#2Atsushi Satake (Kansai Medical University)H-Index: 9
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
view all 14 authors...
ABSTRACT Background Early prediction of nonrelapse mortality (NRM) in patients who undergo allogeneic hematopoietic stem cell transplantation (aHSCT) based on the results of laboratory tests are challenging. There is, therefore, a need for evaluation of biomarkers for prediction of nonrelapse mortality, which is a major problem that offsets the advantages of aHSCT. Objectives We tested the validity and efficacy of two plasma biomarkers (ST2 and Reg3α) based on the Mount Sinai Acute GVHD Internat...
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#1Teruhito TakakuwaH-Index: 3
#2Ryosuke YamamuraH-Index: 4
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
view all 28 authors...
OBJECTIVES This study aimed to investigate real-world data of ixazomib plus lenalidomide and dexamethasone (IRd) therapy for patients with relapsed and refractory multiple myeloma (RRMM). METHODS We retrospectively analyzed 122 patients treated with IRd at 16 centers from May 2017 to January 2019 by using the Kansai Myeloma Forum database. RESULT At the start of IRd, the median age was 72 years, 66.7% of patients had IgG type, and the median number of prior therapies was 4, comprising bortezomib...
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#1Teruhito Takakuwa (OCU: Osaka City University)H-Index: 3
#2Kensuke OhtaH-Index: 23
Last. Itaru Matsumura (Kindai University)H-Index: 43
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Objectives The plateau phase emerging during the treatment of multiple myeloma (MM) is known to last steadily for a certain period, even without treatment. Therefore, the treatment started at plateau phase is expected to be associated with a better outcome. In this study, this hypothesis was evaluated retrospectively for previously treated MM patients in Kansai Myeloma Forum database who received lenalidomide (LEN) with or without dexamethasone for the first time. Method Disease stability index ...
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#1Akiko Konishi (Kansai Medical University)H-Index: 3
#2Misao Abe (Kansai Medical University)H-Index: 2
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
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Abstract Background The human leukocyte antigen (HLA) haplotype of the recipient in hematopoietic stem cell transplantation (HSCT) is a key factor in its success or failure. We analyzed the relationship between HLA haplotype frequency and associated clinical factors in HSCT patients. Methods Patients who underwent allogeneic HSCT between 2000 and 2019 at our institution were enrolled in this study. The HSCT composition was 77 bone marrow transplantations (BMT), 38 peripheral blood stem cell tran...
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#1Teruhito TakakuwaH-Index: 3
#2Kensuke OhtaH-Index: 23
Last. Itaru MatsumuraH-Index: 1
view all 28 authors...
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#1Masaaki Hotta (Kansai Medical University)H-Index: 6
#2Tomoki Ito (Kansai Medical University)H-Index: 26
Last. Shosaku Nomura (Kansai Medical University)H-Index: 52
view all 8 authors...
Few reports have so far described central nervous system (CNS) involvement in multiple myeloma (MM), which shows a poor prognosis owing to its resistance to several treatments. We herein describe a 45-year-old woman who had MM (diagnosed with IgA-κ type) with CNS relapse early after undergoing autologous hematopoietic stem cell transplantation. Because no standard treatment for CNS lesions of MM has been established, we conducted a literature review on the cerebrospinal fluid (CSF) transferabili...
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#1Akiko KonishiH-Index: 3
#2Aya Nakaya (Kansai Medical University)H-Index: 8
Last. Shosaku NomuraH-Index: 52
view all 4 authors...
We report six cases of autoimmune acquired coagulation factor VIII deficiency, which is a rare bleeding disorder. It is an autoimmune disease, however, there are various causes. We experienced cases with malignancy, co-exist with another autoimmune disease, pregnancy, and unknown epidemiology with repeated bleeding episode. All patients were controlled the acute bleeding phase and they have been under treatment with immunosuppression.
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