Manuel Barreiro-de Acosta
University of Santiago de Compostela
Internal medicineSurgeryHumanitiesRetrospective cohort studyTumor necrosis factor alphaProspective cohort studyAdverse effectImmunologyColitisInfliximabInflammatory bowel diseaseDiseaseCrohn's diseaseMEDLINEAdalimumabUlcerative colitisIn patientMedicineCohortGastroenterology
182Publications
24H-index
2,857Citations
Publications 182
Newest
#1Nuno Ferreira (University of Nicosia)H-Index: 12
#2Antonina Mikocka-Walus (Deakin University)H-Index: 29
Last. Megan L. Petrik (UMN: University of Minnesota)H-Index: 7
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Abstract null null Objective null The COVID-19 pandemic has had a significant impact on mental health across the globe. People living with a chronic gastrointestinal (GI) disorder might be particularly at risk of mental health complications given higher rates of comorbid anxiety and depression compared to the healthy population. As GI disorders affect up to 40% of the population worldwide, this international collaborative study seeks to evaluate the extent of the impact of the COVID-19 pandemic ...
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#1María Chaparro (UAM: Autonomous University of Madrid)H-Index: 40
#2Ana Garre (UAM: Autonomous University of Madrid)H-Index: 7
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(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identifi...
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#1Ahmad Albshesh (Sheba Medical Center)H-Index: 3
#2Joshua Taylor (MGH: Montreal General Hospital)
Last. Claire LiefferinckxH-Index: 6
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Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn’s disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described. Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD. Results: Two-hundred and four patients were inc...
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#1Paula SousaH-Index: 8
#2Paula MinistroH-Index: 14
Last. Laurent Peyrin-Biroulet (University of Lorraine)H-Index: 103
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Abstract null null Background and aims null The role of thiopurines in therapeutic algorithms of Crohn's disease (CD) and Ulcerative colitis (UC) is being questioned. This work aimed to investigate current practice and future perspectives of Inflammatory Bowel Disease (IBD) physicians regarding the efficacy, safety, and role of precision medicine with thiopurines in IBD. null null null Methods null A 29-questions web-based survey was developed and distributed to IBD physicians worldwide. null nu...
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#1Antonina Mikocka-Walus (Deakin University)H-Index: 29
#2David Skvarc (Deakin University)H-Index: 5
Last. Lesley A. Graff (UM: University of Manitoba)H-Index: 35
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BACKGROUND The mental health response to the coronavirus (COVID-19) pandemic-related product shortages in those living with chronic gastrointestinal (GI) disorders has received little attention. We aimed to explore the association between the pandemic-related product shortages and psychological distress in people with GI disorders. METHODS This online cross-sectional survey was nested within an ongoing, international, prospective study of well-being in people with GI disorders. The study was adv...
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BACKGROUND One of the most valued targets in inflammatory bowel disease (IBD) is for physicians to provide and patients to receive a high-level quality of care. This study aimed to evaluate the implementation of a nationwide quality certification programme for IBD units. METHODS Identification of quality indicators (QI) for IBD Unit certification was based on Delphi methodology that selected 53 QI, which were subjected to a normalisation process. Selected QI were then used in the certification p...
1 CitationsSource
#2Manuel Barreiro-de Acosta (University of Santiago de Compostela)H-Index: 24
Last. Francesc CasellasH-Index: 29
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Abstract null null Objective null No studies evaluating the rapidity of response to biological therapies are available for Crohn's disease (CD). The aim of this study was to evaluate rapidity of onset of clinical response and impact on quality of life (QoL) of adalimumab therapy in adult anti-TNF-naive patients with moderately-to-severely active CD. null null null Patients and methods null RAPIDA was an open-label, single-arm, prospective, multicenter clinical trial. Adult patients with moderate...
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Inflammatory bowel disease is a multifactorial etiology, associated with environmental factors that can trigger both debut and relapses. A high level of tumor necrosis factor-α in the gut is the main consequence of immune system imbalance. The aim of treatment is to restore gut homeostasis. In this study, fresh blood and serum samples were used to identify biomarkers and to discriminate between Crohn's disease and ulcerative colitis patients under remission treated with anti-TNF. Metabolomics ba...
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Last. Manuel Barreiro-de Acosta (University of Santiago de Compostela)H-Index: 24
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BACKGROUND The long-term outcome of patients after antitumour necrosis factor alpha (anti-TNF) discontinuation is not well known. AIMS To assess the risk of relapse in the long-term after anti-TNF discontinuation. METHODS This was an extension of the evolution after anti-TNF discontinuation in patients with inflammatory bowel disease (EVODIS) study (Crohn's disease or ulcerative colitis patients treated with anti-TNFs in whom these drugs were withdrawn after achieving clinical remission) based i...
3 CitationsSource