Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
137Publications
32H-index
3,178Citations
Publications 138
Newest
#1Roberta Giordo (University of Sassari)H-Index: 13
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
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Evidences that higher natural antioxidant (NA) intake provides protection against cardiovascular disease (CVD) are contradictory. Oxidative-induced endothelial cells (ECs) injury is the key step in the onset and progression of CVD and for this reason the cellular responses resulting from NA interaction with ECs are actively investigated. This study was designed to investigate the direct impact of different naturally occurring antioxidants on the intracellular ROS levels in cultured human ECs. NA...
20 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2A Cossu (University of Sassari)H-Index: 14
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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Evidence that higher natural antioxidants (NA) intake provides cardiovascular protection is contradictory. The endothelium plays a pivotal role in cardiovascular homeostasis, and for this reason, the molecular events resulting from the interaction of NA with endothelial cells (ECs) are actively investigated. Here, we show that moderately high doses of coumaric acid (CA) induced intracellular reactive oxygen species (ROS) production, mitochondrial membrane depolarization and ECs death. Treatment ...
21 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Ciriaco Carru (University of Sassari)H-Index: 38
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A new hydrophilic interaction ultra-performance LC method was established for the whole blood measurement of L-ergothioneine. Chromatographic separation was achieved in a fairly short time, less than 4 min, on a 100 × 2.1 mm Acquity UPLC BEH HILIC 1.7 μm column with a mobile phase consisting of a mixture of 100 mmol/L ammonium acetate/ACN/water (5:85:10, v/v/v) that flowed isocratically at 0.250 mL/min. The LOD and the limit of quantification were 3.85 and 11.67 μmol/L, respectively. The method ...
13 CitationsSource
#1Gaia SpinettiH-Index: 33
#2Orazio FortunatoH-Index: 10
Last. Costanza EmanueliH-Index: 75
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Rationale:Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers. Objective:The objectives were the following: (1) to profile miR expression in PACs from critical limb ischemia (CLI) patients; (2) to demons...
145 CitationsSource
#1Francesco BoinH-Index: 24
Last. Gianfranco PintusH-Index: 32
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#1Ilaria FlorisH-Index: 9
#2Gianfranco PintusH-Index: 32
Last. Costanza EmanueliH-Index: 75
view all 6 authors...
#1A Cossu (University of Sassari)H-Index: 14
#2Anna Maria Posadino (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 10 authors...
The cardiovascular benefits associated with diets rich in fruit and vegetables are thought to be due to phytochemicals contained in fresh plant material. However, whether processed plant foods provide the same benefits as unprocessed ones is an open question. Melanoidins from heat-processed apricots were isolated and their presence confirmed by colorimetric analysis and browning index. Oxidative injury of endothelial cells (ECs) is the key step for the onset and progression of cardiovascular dis...
29 CitationsSource
#1Anna Maria PosadinoH-Index: 19
Last. Luca PrettiH-Index: 7
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Abstract It is increasingly evident that many natural compounds isolated from plants provide benefits to human health, either by interacting with important signalling pathways or by modulating the intracellular redox state. Salvia desoleana is a herbaceous perennial shrub that is native to the island of Sardinia in the Mediterranean Sea. The leaves of S. desoleana were subjected to different extraction methods: hydrodistillation, supercritical CO 2 (SCCO 2 ) extraction at 90 bar and 50 °C, and a...
12 CitationsSource
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
view all 8 authors...