Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
Publications 137
#1Mingyi Wang (NIH: National Institutes of Health)H-Index: 28
#2Jiguang Wang (SJTU: Shanghai Jiao Tong University)
Last. Gianfranco Pintus (Qatar University)H-Index: 32
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This research was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health (MW).
#2Hatem Zayed (College of Health Sciences, Bahrain)H-Index: 20
Last. Gianfranco Pintus (Qatar University)H-Index: 32
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Systemic sclerosis (SSc) is an autoimmune disease characterized by an aberrant immune system response, progressive fibrosis and microvasculature damage that affects organs and systems including skin, lungs, heart, digestive system, kidneys, muscles, joints, and nervous system. Several factors, including genetic and environmental, are involved in the SSc pathogenesis by leading to a pathological autoimmune response, exacerbated extracellular deposition and abnormal vascular restructuring. SSc-ass...
22 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2Grazia BiosaH-Index: 13
Last. Gianfranco PintusH-Index: 32
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The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid–liquid extraction technology (Naviglio Extractor®) was used to obtain polyphenolic antioxidants from the Cagnulari grape marc. The extract was then chemically characterized by spectrophotometric analysis, high-performance liquid chromatography, and mass spectrometry, revealing a total polyphenol content of 4.00 g/L ± 0.05, and the presence of anthocyanins, one of the ...
13 CitationsSource
#1Haissam Abou-Saleh (Qatar University)H-Index: 11
#2Fouad A. Zouein (AUB: American University of Beirut)H-Index: 20
Last. Ali H. Eid (Qatar University)H-Index: 26
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Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a better understanding of molecular and cellular mechanisms of CVD as well as improved therapeutic strategies for the management or treatment of heart failure are increasingly needed. Loss of myocardium is a major driver of heart failure. An attractive approach that appears to provi...
13 CitationsSource
#1Ali H. Eid (Qatar University)H-Index: 26
#2Ahmed F. El-Yazbi (Alexandria University)H-Index: 18
Last. Haissam Abou-Saleh (Qatar University)H-Index: 11
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Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracel...
10 CitationsSource
#1Maria K. Smatti (Qatar University)H-Index: 9
#2Duaa W. Al-Sadeq (College of Health Sciences, Bahrain)H-Index: 8
Last. Gheyath K. Nasrallah (Qatar University)H-Index: 27
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The Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide, and has been linked to several malignancies including PTLDs, which are one of the most common malignancies following transplantation. Among all the EBV genes, most of the recent investigations focused on studying the LMP-1 oncogene because of its high degree of polymorphism and association with tumorig...
49 CitationsSource
#1Gianfranco Pintus (Qatar University)H-Index: 32
#2Roberta Giordo (Qatar University)H-Index: 13
Last. Edward G. Lakatta (NIH: National Institutes of Health)H-Index: 166
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// Gianfranco Pintus 1, 2, * , Roberta Giordo 1, 2, * , Yushi Wang 1, 3 , Wanqu Zhu 1 , Soo Hyuk Kim 1 , Li Zhang 1, 4 , Leng Ni 1, 5 , Jing Zhang 1 , Richard Telljohann 1 , Kimberly R. McGraw 1 , Robert E. Monticone 1 , Chloe Ferris 1 , Lijuan Liu 1 , Mingyi Wang 1 and Edward G. Lakatta 1 1 Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), Baltimore, MD, USA 2 Biomedical Research Center, Qatar University, Doha, Qa...
5 CitationsSource
#1Nadin Younes (College of Health Sciences, Bahrain)H-Index: 10
#2Rola Salem (Qatar University)H-Index: 2
Last. Gheyath K. Nasrallah (Qatar University)H-Index: 27
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Abstract Hydrate formation in seafloor pipelines is considered an economic and flow assurance issue for the oil and gas industries. Ionic liquids (ILs) have been recently used as potential hydrate inhibitors. Although branded as green compounds, their ecotoxicity in case of leakage from pipelines onto the aquatic environment needs more deep evaluations. Here, we investigate the impacts of three ILs previously used as successful thermodynamic hydrate inhibitors namely choline chloride (ChC1), 1-m...
11 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Elisabetta SotgiuH-Index: 9
Last. Ciriaco CarruH-Index: 38
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Alterations in global DNA methylation are implicated in various pathophysiological processes. The development of simple and quick, yet robust, methods to assess DNA methylation is required to facilitate its measurement and interpretation in clinical practice. We describe a highly sensitive and reproducible capillary electrophoresis method with UV detection for the separation and detection of cytosine and methylcytosine, after formic acid hydrolysis of DNA extracted from human whole blood. Hydrol...
2 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Ciriaco Carru (University of Sassari)H-Index: 38
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Abstract In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum concentrations of this biomarker of systemic immune and inflammation activation, were measured in a small cohort of Sardinian middle-aged, older adults and centenarians. There was a significant positive correlation between neopterin concentrations and age with the subjects...
3 CitationsSource