David Bradley
The Ohio State University Wexner Medical Center
Internal medicineEndocrinologySurgeryAdipose tissueChemistryAdipokinePancreatitisAdipocyteInflammationType 2 diabetesInsulin resistancePostprandialInsulinContext (language use)Pancreatic cancerBody mass indexOverweightType 2 Diabetes MellitusGlucose homeostasisObesityWeight lossDiabetes mellitusMedicineCohortBiologyGastroenterology
55Publications
15H-index
1,502Citations
Publications 55
Newest
#1Sean M. Phelan (Mayo Clinic)H-Index: 28
#2Katherine W. Bauer (UM: University of Michigan)H-Index: 26
Last. Ivana T. Croghan (Mayo Clinic)H-Index: 53
view all 10 authors...
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#1Phil A. Hart (The Ohio State University Wexner Medical Center)H-Index: 29
#2David Bradley (The Ohio State University Wexner Medical Center)H-Index: 15
Last. Jose Serrano (NIH: National Institutes of Health)H-Index: 49
view all 11 authors...
Summary null null Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diab...
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#1Anahita Jalilvand (OSU: Ohio State University)H-Index: 8
#2Alecia Blaszczak (OSU: Ohio State University)H-Index: 7
Last. Sabrena Noria (OSU: Ohio State University)H-Index: 14
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BACKGROUND Adipose tissue (AT) inflammation is linked to the development of type 2 diabetes (T2DM) and atherosclerosis in murine models of obesity. Reduced AT regulatory T cells (Tregs), which are anti-inflammatory immune cells, play an important part in this pathogenesis, and we have shown that AT-Tregs are inversely correlated to increasing body-mass-index. The purpose of this study was to evaluate the association between AT-Treg abundance and comorbidity status in patients undergoing bariatri...
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#1Stephen A. Firkins (The Ohio State University Wexner Medical Center)
#2Phil A. HartH-Index: 29
Last. Somashekar G. KrishnaH-Index: 21
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OBJECTIVES There is a paucity of studies evaluating predictors of new-onset diabetes mellitus (DM) after acute pancreatitis (AP-related DM). We used a population-based database to evaluate predictors of AP-related DM. METHODS The Nationwide Readmissions Database (2010-2014) was used to identify all nondiabetic adults with an index primary diagnosis of AP. Multiple exclusions were applied to identify cohorts with and without AP-related DM. A case-control study was conducted to identify risk facto...
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#1Manpreet S. Mundi (Mayo Clinic)H-Index: 3
#1Manpreet S. Mundi (Mayo Clinic)H-Index: 3
Last. Ivana T. CroghanH-Index: 53
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Abstract Objective To evaluate the association between obesity and history of childhood trauma in an effort to define implications for the provider-patient relationship and possible causes of failure of obesity treatment. Methods Multisite survey developed by the Patient-Centered Outcomes Research Institute Learning Health Systems Obesity Cohort Workgroup consisting of 49 questions with 2 questions focusing on history of being a victim of childhood physical and/or sexual abuse was mailed to 19,9...
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#1Paul J. Novotny (Mayo Clinic)H-Index: 81
#2Darrell R. Schroeder (Mayo Clinic)H-Index: 97
Last. Ivana T. Croghan (Mayo Clinic)H-Index: 53
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Abstract Objective To determine the effects of missing and inconsistent data on a weight management mail survey results. Patients and Methods Weight management surveys were sent to 5000 overweight and obese individuals in the Learning Health System Network. Survey information was collected between October 27, 2017, and March 1, 2018. Some participants reported body mass index (BMI) values inconsistent with the intended overweight and obese sampling cohort. Analyses were performed after excluding...
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#1Jennifer A. Wittwer (OSU: Ohio State University)H-Index: 6
#2David Bradley (OSU: Ohio State University)H-Index: 15
The cardiometabolic syndrome involves a clustering of metabolic and cardiovascular factors which increase the risk of patients developing both Type 2 Diabetes Mellitus and cardio/cerebrovascular disease. Although the mechanistic underpinnings of this link remain uncertain, key factors include insulin resistance, excess visceral adiposity, atherogenic dyslipidemia and endothelial dysfunction. Of these, a state of resistance to insulin action in overweight/obese patients appears to be central to t...
1 CitationsSource
#1David Bradley (OSU: Ohio State University)H-Index: 15
#2Dharti Shantaram (OSU: Ohio State University)
Last. Willa A. Hsueh (OSU: Ohio State University)H-Index: 86
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Obesity dramatically increases the risk of numerous conditions, including type 2 diabetes mellitus and other components of the metabolic syndrome. Pro-inflammatory changes that occur in adipose tissue are critical to the pathogenesis of these obesity-induced complications. Adipose tissue is one of the body's largest endocrine organs, and the cells that comprise the adipose tissue immunoenvironment secrete multiple factors (including adipokines and cytokines) that impact systemic metabolism. In p...
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#1David Bradley (OSU: Ohio State University)H-Index: 15
Over 35% of the adult US population is obese. In turn, excess adiposity increases the risk of multiple complications including type 2 diabetes (T2D), insulin resistance, and cardiovascular disease; yet, obesity also independently heightens risk of Alzheimer's Disease (AD), even after adjusting for other important confounding risk factors including blood pressure, sociodemographics, cholesterol levels, smoking status, and Apolipoprotein E (ApoE) genotype. Among patients over the age of 65 with de...
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