Markus Böhm
University of Münster
EndocrinologyPathologyMolecular biologyDermatologyReceptorChemistryImmunologyInflammationAlopecia areataMelanomaVitiligoMelanocortinMelanocyte-stimulating hormoneProopiomelanocortinMelanocortinsHormoneMedicineBiologyImmune systemCell biology
Publications 188
#1Nicoline F Post (UvA: University of Amsterdam)
#2Rosalie M. Luiten (UvA: University of Amsterdam)H-Index: 28
Last. Markus Böhm (WWU: University of Münster)H-Index: 51
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The SARS-CoV-2 pandemic has evolved to a global health problem with a dramatic morbidity and mortality rate impacting our daily life and those of many patients. While there is evidence that some diseases are associated with an increased risk for development of a more severe course of COVID-19, little is known on protective conditions. Importantly, clearance of viral infection and protection against disease manifestation crucially depends on functional innate and adaptive immunity and the interfe...
Alemtuzumab is currently approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). Despite the efficacy of this therapy several side effects in the skin have been noted during or after infusion including vitiligo, alopecia areata, malignant skin tumors and infections. Awareness of these effects and their treatment is of essential interdisciplinary importance. This minireview provides an overview of the dermatological side effects described in the current literature. We ...
Last. Markus BöhmH-Index: 51
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Die generalisierte pustulose Psoriasis ist eine seltene, oftmals schubweise auftretende und meist schwere entzundliche Dermatose mit teils starken Allgemeinbeschwerden. Einem Teil dieser Falle liegen Mutationen im Gen des Interleukin-36-Rezeptorantagonisten (IL36RN) zugrunde, die den autoinflammatorischen Charakter der Erkrankung erklaren. Wir berichten uber eine 39-jahrige, hochschwangere Patientin, die eine Therapie mit Secukinumab aufgrund der Schwangerschaft abgesetzt hatte und sich nun mit ...
#1Lena Dietze (WWU: University of Münster)
#2Dieter Metze (WWU: University of Münster)H-Index: 62
Last. Markus Böhm (WWU: University of Münster)H-Index: 51
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#1Yuval Ramot (HUJI: Hebrew University of Jerusalem)H-Index: 28
#2Markus Böhm (WWU: University of Münster)H-Index: 51
Last. Ralf Paus (University of Manchester)H-Index: 128
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Human skin responds to numerous neurohormones, neuropeptides, and neurotransmitters that reach it via the vasculature or skin nerves, and/or are generated intracutaneously, thus acting in a para- and autocrine manner. This review focuses on how neurohormones impact on human skin physiology and pathology. We highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research w...
3 CitationsSource
#1Agatha Stegemann (WWU: University of Münster)H-Index: 7
#2Damian Jozef FlisH-Index: 10
Last. Markus Böhm (WWU: University of Münster)H-Index: 51
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Abstract Targeting neuroendocrine receptors can be considered as another interesting approach to treat fibrotic disorders. Previously, we could demonstrate that tropisetron, a classical serotonin receptor blocker, can modulate collagen synthesis and acts in vitro via the α7 nicotinic acetylcholine receptor (α7nAchR). Here, we used a pharmacological approach with specific α7nAchR agonists to validate this hypothesis. PHA-543613, a α7nAchR-specific agonist did not only prevent but also reversed es...
2 CitationsSource
Melanocortins are peptides that share a common central pharmacophor. Melanin pigmentation of interfollicular epidermis and hair via MC1R remains the key physiologic function of the naturally occurring melanocortin peptides in skin. Moreover, the melanocortins are crucially involved in the ultraviolet light-induced tanning response. Under pathophysiologic conditions, melanocortin peptides induce cutaneous hyperpigmentation, likewise via the MC1R axis, e.g. in patients with Addison's disease, ecto...
1 CitationsSource
#1Markus Böhm (WWU: University of Münster)H-Index: 51
#2Ralf Paus (University of Manchester)H-Index: 128