Simon P. Hart
Hull York Medical School
Internal medicinePathologyPhagocytosisReceptorChemistryPhysical therapyApoptosisImmunologyInflammationInterstitial lung diseaseIdiopathic pulmonary fibrosisMacrophageMEDLINEPulmonary fibrosisMedicineBiologyGastroenterologyCell biology
165Publications
26H-index
2,179Citations
Publications 160
Newest
#1Simon D. FraserH-Index: 1
#2Michael G. CrooksH-Index: 12
Last. Simon P. HartH-Index: 26
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#1S Thackray-Nocera (University of Hull)
Last. Simon P. HartH-Index: 26
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Introduction and Objectives Cough is a distressing symptom for some patients with pulmonary sarcoidosis. Long term treatment with azithromycin may improve cough. We aimed to assess potential efficacy of azithromycin in patients with pulmonary sarcoidosis with self-reported cough. Methods We did a non-controlled, single arm, open label clinical trial of azithromycin 250 mg once daily for 3 months in patients with pulmonary sarcoidosis who reported a chronic cough. The primary outcome was 24-hour ...
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#1Matthew Northgraves (University of Hull)H-Index: 6
#2Judith CohenH-Index: 8
Last. Ann HutchinsonH-Index: 6
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Introduction: Chronic breathlessness, persistent and disabling despite optimal treatment of underlying causes, is a prevalent and frightening symptom and is associated with many emergency presentations and admission to hospital. Breathlessness management techniques used by paramedics may reduce the need for conveyance to hospital. The Breathlessness RElief AT HomE study (BREATHE) aims to explore the feasibility of conducting a definitive cluster randomised controlled trial (cRCT) for people with...
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#1Simon D. FraserH-Index: 1
#2Michael G. CrooksH-Index: 12
Last. Simon P. HartH-Index: 26
view all 4 authors...
Background In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 and CD16. Regulatory receptors serve to dampen monocyte and macrophage inflammatory responses. We investigated the relationship between monocyte subsets and regulatory receptor expression in sarcoidosis. Methods Multiparameter flow cytometry was used to...
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#1Muhunthan Thillai (Papworth Hospital)H-Index: 9
#2CP Atkins (NNUH: Norfolk and Norwich University Hospital)H-Index: 6
Last. Athol U. WellsH-Index: 122
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This British Thoracic Society (BTS) Clinical Statement addresses the diagnosis, evaluation and management of pulmonary sarcoidosis, with each section summarised with key clinical practice points. In an era in which medical practice is increasingly determined by evidence-based guidelines, it must be acknowledged from the outset that current evidence in sarcoidosis, especially with regard to treatment, is weak. Thus, a number of the conclusions in this Statement are based on expert opinion and acc...
10 CitationsSource
Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.Objectives: To assess outcomes in patients with ILD hospitalized fo...
49 CitationsSource
#1Leigh Naylor-Adamson (Hull York Medical School)
#2Zoe Booth (University of Hull)
Last. Mònica Arman (Hull York Medical School)H-Index: 16
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#1Simon D. Fraser (Hull York Medical School)H-Index: 1
#2Susannah Thackray-Nocera (Castle Hill Hospital)H-Index: 3
Last. Simon P. Hart (Hull York Medical School)H-Index: 26
view all 11 authors...
Background Chronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis and self-reported cough. Methods We conducted a noncontrolled, open-label clinical trial of azithromycin 250 mg once daily for 3 months in patients with pulmonary sarcoidosis who reported a chronic cough. The primary outcome was number of coughs in 24...
1 CitationsSource
Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4...
5 CitationsSource