Harold M. Burkhart
University of Oklahoma Health Sciences Center
Internal medicineRadiologySurgeryCardiologyRetrospective cohort studyAortic valve replacementArteryMitral valveHeart failureCardiac surgeryCardiopulmonary bypassTricuspid valveAortaHeart diseaseRegurgitation (circulation)Mitral valve repairAortic valveMitral regurgitationMedicineEjection fraction
280Publications
54H-index
5,405Citations
Publications 282
Newest
#1Emily L. Johnson (Iowa State University)H-Index: 6
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Ming-Chen Hsu (Iowa State University)H-Index: 40
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Abstract null null Approximately 1.6 million patients in the United States are affected by tricuspid valve regurgitation, which occurs when the tricuspid valve does not close properly to prevent backward blood flow into the right atrium. Despite its critical role in proper cardiac function, the tricuspid valve has received limited research attention compared to the mitral and aortic valves on the left side of the heart. As a result, proper valvular function and the pathologies that may cause dys...
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#1Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
Last. Arshid MirH-Index: 8
view all 3 authors...
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#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Keely A. Laurence (OU: University of Oklahoma)
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Abstract null null The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of blood through a coordination of the extracellular matrix components, including the collagen fibers, elastin, and glycosaminoglycans. Dysfunction of the AHVs, such as those caused by unfavorable microstructural remodeling, lead to valvular heart diseases and improper blood flow, which can ultimately cause heart failure. In order to better understand the mechanics and remodeling of the ...
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#1Arshid Mir (University of Oklahoma Health Sciences Center)H-Index: 8
#2Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
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#1Marie Vincenti (Mayo Clinic)H-Index: 1
#2Patrick W. O'Leary (Mayo Clinic)H-Index: 41
Last. Joan Wobig (Mayo Clinic)H-Index: 2
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Preservation of right ventricle function (RV) is a key to favorable outcome in Hypoplastic Left Heart Syndrome (HLHS), but methods to preserve or improve RV function are limited. Our goal was to assess the clinical and functional impact of autologous umbilical cord blood-derived mononuclear cells (UCB-MNC) therapy when given to patients with HLHS at Stage II surgery. UCB-MNC patients were enrolled prospectively in a phase I, FDA monitored trial as previously described (Burkhart et al., 2019). Ma...
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#1Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
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#1Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
#2Heather N. Anderson (University of Oklahoma Health Sciences Center)H-Index: 6
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#1Harold M. BurkhartH-Index: 54
#2Heather N. Anderson (University of Oklahoma Health Sciences Center)H-Index: 6
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#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Brennan T. Mullins (OU: University of Oklahoma)H-Index: 1
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
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Abstract Collagen fibers are the primary load-bearing microstructural constituent of bodily soft tissues, and, when subjected to external loading, the collagen fibers reorient, uncrimp, and elongate. Specific to the atrioventricular heart valve leaflets, the collagen fiber kinematics form the basis of many constitutive models; however, some researchers claim that modeling the affine fiber kinematics (AFK) are sufficient for accurately predicting the macroscopic tissue deformations, while others ...
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#1Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
#2Emilie D. Henry (University of Oklahoma Health Sciences Center)
Last. Randall M. Schwartz (University of Oklahoma Health Sciences Center)
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