Yunli Zhao
Shenyang Pharmaceutical University
PharmacokineticsAnalytical chemistryDetection limitMass spectrometryHigh-performance liquid chromatographyBioavailabilityChemistryDecoctionCalibration curveFormic acidBenzoic acidEthyl acetateAmmonium acetateTandem mass spectrometryElectrospray ionizationChromatographyExtraction (chemistry)Liquid chromatography–mass spectrometrySelected reaction monitoringProtein precipitationPharmacology
76Publications
16H-index
644Citations
Publications 77
Newest
#1Jiaofeng Wu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Baichun Hu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 10 authors...
Abstract null null α-Glucosidase is a promising target for the treatment of diabetes. Drug repurposing can increase the chances of discovering an active inhibitor. Therefore, this study aimed to identify potential α-glucosidase inhibitor using drug repurposing and in silico strategies. We identified critical amino acid residues of the three α-glucosidase proteins. Based on cross molecular docking studies of three α-glucosidase proteins and drugs in the FDA database, we screened hits with the fav...
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#1Ting Liu (Shenyang Medical College)H-Index: 4
#2Ruiyun Li (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 6 authors...
An ultra-high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) metabonomic approach was employed to screen the differential components between normal rats and yeast-induced pyrexia rats after an oral administration of Gegenqinlian decoction (GQLD). Nine compounds, including puerarin, daidzein, baicalin, wogonoside, wogonin, berberine, palmatine, jateorhizine, and coptisine were identified as differential components in t...
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#1Shaoyun Wang (SPU: Shenyang Pharmaceutical University)
#2Xiaozhu Sun (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 6 authors...
Polygoni Multiflori Radix Praeparata (PMRP), as the processed product of tuberous roots of Polygonum multiflorum Thunb., is one of the most famous traditional Chinese medicines, with a long history. However, in recent years, liver adverse reactions linked to PMRP have been frequently reported. Our work attempted to investigate the chemical constituents of PMRP for clinical research and safe medication. In this study, an effective and rapid method was established to separate and characterize the ...
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#1Rui-zhen Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Jing-Tao Zhao (UCL: University College London)H-Index: 1
Last. Yunli Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 7 authors...
Abstract Viscum coloratum (Kom.) Nakai is a well-known medicinal hemiparasite widely distributed in Asia. The synthesis and accumulation of its metabolites are affected by both environmental factors and the host plants, while the latter of which is usually overlooked. The purpose of this study is to comprehensively evaluate the effects of host and habitat on the metabolites in V. coloratum through multiple chemical and biological approaches. The metabolite profile of V. coloratum harvested from ...
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#1Ting Liu (Shenyang Medical College)H-Index: 4
#2Ruiyun Li (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Yunli Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 5 authors...
Abstract A metabonomic approach involving an ultrahigh-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) was used to investigate the changes in the endogenous metabolites in the plasma of rats with yeast-induced pyrexia treated with Gegenqinlian decoction (GQLD), aspirin and itraconazole. The differences in the small molecule profiles of treatment using Traditional Chinese medicine, etiological treatment and symptomatic ...
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#1Yan ShiH-Index: 11
#2Roujia Wang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Ping XiangH-Index: 9
view all 10 authors...
Abstract Tryptamines are hallucinogenic substances many of which have appeared recently as novel psychoactive substances (NPS). Herein, we describe the establishment of a rapid UHPLC-MS/MS quantitative method for the targeted screening of 16 tryptamines of abuse in hair. Twenty milligram pieces of hair were pulverized below 4 °C in 0.5 mL of deionized water containing 0.1% formic acid and an internal standard (2 ng/mL psilocin-d10 and psilocybin-d4). After subsequent centrifugation, 5 μL of the ...
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#1Jiaofeng Wu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Baichun Hu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 11 authors...
Abstract Drug repositioning is a popular method of making drug discovery less costly and more efficient. Computational methods such as pharmacophore-based virtual screening, molecular docking, and molecular dynamics (MD) simulations have been widely utilized to make the process of finding drugs more efficient and accurate. In this study, “in silico repositioning” was performed to identify promising α-glucosidase inhibitors among existing drugs. Based on molecular dynamics simulations analysis of...
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#1Jing Hong (SPU: Shenyang Pharmaceutical University)
#2Lin Meng (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Yunli Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 8 authors...
(1E,4E)-1,7-Bis(4-hydroxyphenyl)hepta-1,4-dien-3-one (DHDK) is a novel curcuminoid analogue isolated from mistletoe. DHDK exhibits better anti-tumour activity, higher bioavailability and superior stability than curcumin. DHDK is difficult to isolate from Viscum coloratum, but it can be synthesised. MTT (methylthiazolyldiphenyl tetrazolium bromide) assay was used to evaluate the in vitro cytotoxic activity of synthesised DHDK on 12 cancer cell lines. Results showed that DHDK exhibited excellent p...
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#1Rong Rong (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Qi-li Zhang (SDUT: Shandong University of Technology)
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 7 authors...
R-/S-2-(2-Hydroxypropanamido)-5-trifluoromethyl benzoic acid (R-/S-HFBA), as a novel COX inhibitor, was firstly reported to have remarkable anti-inflammatory and antiplatelet aggregation activities by our group. In our previous study, stereoselective differences in pharmacokinetics were found between HFBA enantiomers after oral and intravenous administration of each enantiomer to rats. The discrepancies might be associated with the excretion and metabolism of the two enantiomers. In this researc...
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#1Xiuying Yan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Ping XiangH-Index: 11
Last. Hui YanH-Index: 4
view all 5 authors...
PURPOSE: 5-Methoxy-N,N-Diisopropyltryptamine (5-MeO-DIPT) is a designer hallucinogen derived from tryptamine, and its use has been banned by many countries. In this study, a qualitative and quantitative method was developed for determining 5-MeO-DIPT in urine by gas chromatography high resolution mass spectrometry; 5-OH-DIPT and 5-MeO-IPT were identified as 5-MeO-DIPT metabolites in abusers' urine. METHODS: 5-MeO-DIPT was extracted from urine by liquid-liquid extraction with ethyl acetate under ...
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