Charles DeCarli
University of California, Davis
Framingham Heart StudyFramingham Risk ScorePathologyMagnetic resonance imagingHyperintensityPsychologyCardiologyNeuroscienceCognitionDiseaseDementiaAtrophyWhite matterCognitive declineAlzheimer's diseaseStrokeNeuroimagingBrain sizeMedicineCohort
771Publications
113H-index
52.7kCitations
Publications 773
Newest
#1Orit H. Lesman-Segev (UCSF: University of California, San Francisco)H-Index: 6
#2Renaud La Joie (UCSF: University of California, San Francisco)H-Index: 33
Last. Gil D. Rabinovici (UCSF: University of California, San Francisco)H-Index: 59
view all 23 authors...
Objective To compare the diagnostic accuracy of antemortem [11 C]Pittsburgh Compound B (PIB) and [18 F]Flurodeoxyglucose (FDG) positron emission tomography (PET) versus autopsy diagnosis in a heterogenous sample of patients. Methods 101 participants underwent PIB and FDG PET during life and neuropathological assessment. PET scans were visually interpreted by three raters blinded to clinical information. PIB PET was rated as positive or negative for cortical retention while FDG scans were read as...
1 CitationsSource
#1Brian W. Kunkle (UM: University of Miami)H-Index: 19
#2Michael A. Schmidt (UM: University of Miami)H-Index: 12
Last. Walter A. Kukull (UW: University of Washington)H-Index: 86
view all 78 authors...
Importance Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African American individuals, ABCA7, TREM2, and an intergenic locus at 5q35 were previously implicated. Objective To ...
4 CitationsSource
#1A Baril (BU: Boston University)H-Index: 1
#2Alexa Beiser (BU: Boston University)H-Index: 94
Last. Jayandra J. Himali (University of Texas Health Science Center at San Antonio)
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Objective: To test the hypothesis that reduced slow-wave sleep, or N3 sleep, which is thought to underlie the restorative functions of sleep, is associated with MRI markers of brain aging, we evaluated this relationship in the community-based Framingham Heart Study Offspring cohort using polysomnography and brain MRI. Methods: We studied 492 participants (58.8 ± 8.8 years, 49.4% male) free of neurological diseases who completed a brain MRI scan and in-home overnight polysomnography to assess slo...
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#2Hideaki Suzuki (Imperial College London)H-Index: 10
Last. Stéphanie Debette (University of Bordeaux)H-Index: 51
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White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime imp...
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#1Rachel A. Whitmer (UC Davis: University of California, Davis)H-Index: 40
#2Claudia H. Kawas (UCI: University of California, Irvine)H-Index: 66
Last. Maria M. Corrada (UCI: University of California, Irvine)H-Index: 37
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#1Kristen M. George (UC Davis: University of California, Davis)H-Index: 1
#2Rachel A. Whitmer (UC Davis: University of California, Davis)H-Index: 40
Last. Charles DeCarli (UC Davis: University of California, Davis)H-Index: 113
view all 7 authors...
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#1Stephan Seiler (UC Davis: University of California, Davis)H-Index: 20
#2Evan Fletcher (UC Davis: University of California, Davis)H-Index: 31
Last. Charles DeCarli (UC Davis: University of California, Davis)H-Index: 113
view all 8 authors...
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#1Charles DeCarli (UC Davis: University of California, Davis)H-Index: 113
#2Kelsey Erickson (UC Davis: University of California, Davis)
Last. Lee-Way Jin (UC Davis: University of California, Davis)H-Index: 48
view all 11 authors...
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#1Zarui A. Melikyan (UCI: University of California, Irvine)H-Index: 4
#2Bryce A. Mander (UCI: University of California, Irvine)H-Index: 16
Last. Maria M. Corrada (UCI: University of California, Irvine)H-Index: 37
view all 8 authors...
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#1Maria M. Corrada (UCI: University of California, Irvine)H-Index: 37
#2Claudia H. Kawas (UCI: University of California, Irvine)H-Index: 66
Last. Rachel A. Whitmer (UC Davis: University of California, Davis)H-Index: 40
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