Michael J. Lyons
Boston University
PsychiatryInternal medicineDevelopmental psychologyNeuropsychologyDemographyPsychologyHeritabilityTwin studyNeuroscienceCognitionPersonalityDepression (differential diagnoses)DiseaseComorbidityMiddle ageRisk factorGeneticsClinical psychologyMedicineBiology
Publications 417
#1Jennifer A. Sumner (UCLA: University of California, Los Angeles)H-Index: 27
#2Adam X. Maihofer (UCSD: University of California, San Diego)H-Index: 22
Last. Bekh Bradley (Emory University)H-Index: 66
view all 0 authors...
Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Heal...
#2Lynne M. Bird (UCSD: University of California, San Diego)H-Index: 31
Last. Michael J. LyonsH-Index: 85
view all 24 authors...
The DEAD/DEAH box RNA helicases are a superfamily of proteins involved in the processing and transportation of RNA within the cell. A growing literature supports this family of proteins as contributing to various types of human disorders from neurodevelopmental disorders to syndromes with multiple congenital anomalies. This article presents a cohort of nine unrelated individuals with de novo missense alterations in DDX23 (Dead-Box Helicase 23). The gene is ubiquitously expressed and functions in...
#1Ilaria Parenti (University of Duisburg-Essen)H-Index: 11
#1Ilaria Parenti (University of Duisburg-Essen)
Last. Cyril Mignot (University of Paris)H-Index: 22
view all 45 authors...
Located in the critical 1p36 microdeletion region, the chromodomain helicase DNA-binding protein 5 (CHD5) gene encodes a subunit of the nucleosome remodeling and deacetylation (NuRD) complex required for neuronal development. Pathogenic variants in six of nine chromodomain (CHD) genes cause autosomal dominant neurodevelopmental disorders, while CHD5-related disorders are still unknown. Thanks to GeneMatcher and international collaborations, we assembled a cohort of 16 unrelated individuals harbo...
#1Seok-Ho YuH-Index: 14
#2Tong WangH-Index: 2
Last. Richard SteetH-Index: 22
view all 14 authors...
Purpose Variants in NUS1 are associated with a congenital disorder of glycosylation, developmental and epileptic encephalopathies, and are possible contributors to Parkinson disease pathogenesis. How the diverse functions of the NUS1-encoded Nogo B receptor (NgBR) relate to these different phenotypes is largely unknown. We present three patients with de novo heterozygous variants in NUS1 that cause a complex movement disorder, define pathogenic mechanisms in cells and zebrafish, and identify pos...
#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 18 authors...
Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 30 authors...
INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 85
view all 27 authors...
Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource
#1Riki E Slayday (SDSU: San Diego State University)
#2Daniel E. Gustavson (UCSD: University of California, San Diego)H-Index: 16
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
view all 14 authors...
OBJECTIVE Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) e4 allele, a risk factor for Alzheimer's disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would sho...