Serdar Nepesov
Istanbul Medipol University
GeneInternal medicineMucocutaneous zoneAllelePediatricsImmunologyChronic mucocutaneous candidiasisImmunodeficiencyChronic granulomatous diseasePrimary immunodeficiencyDiseaseDock8Severe combined immunodeficiencyFamily historyTransplantationIn patientGeneticsFlow cytometryMedicineBiology
20Publications
5H-index
223Citations
Publications 20
Newest
#1Sezin Aydemir (Istanbul University)H-Index: 1
#2Ali Islek (Atatürk University)H-Index: 7
Last. Ahmet Ozen (Marmara University)H-Index: 22
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#1Pınar Özge Avar-Aydın (Istanbul University)
#2Serdar Nepesov (Istanbul University)H-Index: 5
Last. Ozgur Kasapcopur (Istanbul University)H-Index: 35
view all 7 authors...
To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. Ninety-nine JIA patients and 128 control subjects were enrolled ...
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#1Nihan Bayram (Istanbul Medipol University)
#2Yöntem Yaman (Istanbul Medipol University)H-Index: 1
Last. Sema Anak (Istanbul Medipol University)H-Index: 16
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Introduction (Ph-like) ALL is a subset of leukemia which has a gene expression profile similar to Ph+disease, but without the presence of BCR-ABL1 translocation. Case description We reported an exceptional case of a child with relapsed Ph-like ALL with IKZF1 gene deletion treated with high-dose ruxolitinib as monotherapy, after multi-agent chemotherapy. He remains in continued MRD-negative leukemia remission with full donor chimerism at 12 months post-HSCT. Discussion The circumstance that makes...
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#1Yöntem Yaman (Istanbul Medipol University)H-Index: 1
#2Murat Elli (Istanbul Medipol University)H-Index: 1
Last. Sema Anak (Istanbul Medipol University)H-Index: 16
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Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogeneic HSCT thrombocytopenia, appears efficacious, and offers transfusion independence. To evaluate the safety and efficacy of ELT in pediatric patients with prolonged isolated thrombo...
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#1Deniz Aygun (Istanbul University)H-Index: 4
Last. Yildiz Camcioglu (Istanbul University)H-Index: 25
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BACKGROUND Chronic granulomatous disease (CGD) is a rare genetic disorder characterized by failure of phagocytic leukocytes to destroy certain microbes. We present a study on CGD patients enrolled at a single medical center concerning the infectious and noninfectious complications and genetic properties of the disease. METHODS Icotinamide adenine dinucleotide phosphate oxidase activity and the expression of flavocytochrome b558 were measured by flow cytometry, and clinical outcomes of the patien...
1 CitationsSource
#1Sinem FirtinaH-Index: 9
#2Yuk Yin Ng (Istanbul Bilgi University)H-Index: 2
Last. Muge SayitogluH-Index: 9
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: Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple presentations. The advent of next-generation sequencing (NGS) has recently enabled rapid identification of the molecular aetiology of SCID, which is crucial for prognosis and treatment strategies. We sought to identify the genetic aetiology of various phenotypes of SCIDs and assessed both clinical and immunologic characte...
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#1Serdar Nepesov (Istanbul University)H-Index: 5
#2Fatma Deniz Aygün (Istanbul University)H-Index: 3
Last. Yildiz Camcioglu (Istanbul University)H-Index: 25
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Abstract Introduction and objectives Common variable immunodeficiency (CVID) is one of the most prevalent forms of primary immunodeficiency characterized by hypogammaglobinemia. Its heterogeneous clinical features include recurrent respiratory tract infections and other complications such as gastrointestinal, autoimmunity, and lymphoproliferative disorders. The aim of this article is to evaluate the general characteristics of CVID patients. Materials and methods Clinical and immunological featur...
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#1Serdar Nepesov (Istanbul University)H-Index: 5
#2Fatma Deniz Aygün (Istanbul University)H-Index: 3
Last. Yildiz Camcioglu (Istanbul University)H-Index: 25
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Aim: The aim of this study was to identify the clinical and immunologic features of patients with 22q11.2 deletion syndrome who were followed up in our clinic. Thus, it is aimed to identify the syndrome early, choose the right treatment options according to humoral and cellular immunologic analysis, and enlighten how to follow up these kinds of patients with immunodeficiencies.
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#1Asiye Karakullukcu (Istanbul University)H-Index: 6
#2Hrisi Bahar Tokman (Istanbul University)H-Index: 6
Last. Bekir KocazeybekH-Index: 18
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Background Helicobacter pylori quantity and HP-NAP gene expression were evaluated in the faeces of healthy and asthmatic children. Methods H. pylori DNAs and RNAs were isolated from the stool samples of 92 asthmatic children (AC; 3–8 years) and 88 healthy controls (HC). Quantitative PCR was used to determine the quantity of H. pylori and HP-NAP expression relative to the 16S rRNA (reference gene). Gene expression was analysed using the delta delta-Ct method. Results H. pylori DNA was detected in...
5 CitationsSource
#1Sinem Firtina (Istanbul University)H-Index: 9
#2Yuk Yin Ng (Istanbul Bilgi University)H-Index: 2
Last. Muge Sayitoglu (Istanbul University)H-Index: 9
view all 11 authors...
Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiency, which is characterized by the dysfunction and/or absence of T lymphocytes. Early diagnosis of SCID is crucial for overall survival, and if it remains untreated, SCID is often fatal. Next-generation sequencing (NGS) has become a rapid, high-throughput technology, and has already been proven to be beneficial in medical diagnostics. In this study, a targeted NGS panel was developed to identify the genetic v...
8 CitationsSource