Terry L. Jernigan
University of California, San Diego
AnatomyPsychiatryInternal medicineDevelopmental psychologyCognitive developmentNeuropsychologyPathologyMagnetic resonance imagingBrain morphometryPsychologyNeuroscienceCognitionNeurocognitiveGrey matterCerebral cortexTemporal lobeWhite matterBrain mappingAudiologyNeuroimagingMedicineBiology
Publications 279
#1Clare E. Palmer (UCSD: University of California, San Diego)H-Index: 11
#2Chandni Sheth (UofU: University of Utah)H-Index: 7
Last. Marybel Robledo Gonzalez (UCSD: University of California, San Diego)H-Index: 4
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Physical health in childhood is crucial for neurobiological as well as overall development, and can shape long-term outcomes into adulthood. The landmark, longitudinal Adolescent Brain Cognitive Development StudySM (ABCD study), was designed to investigate brain development and health in almost 12,000 youth who were recruited when they were 9-10 years old and will be followed through adolescence and early adulthood. The overall goal of this paper is to provide descriptive analyses of physical he...
#1Anthony Steven Dick (FIU: Florida International University)H-Index: 21
#2Daniel A Lopez (URMC: University of Rochester Medical Center)H-Index: 2
Last. Andrew T. Marshall (SC: University of Southern California)H-Index: 14
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Abstract null null The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, e...
3 CitationsSource
#1Bader Chaarani (UVM: University of Vermont)H-Index: 12
#2Sage Hahn (UVM: University of Vermont)H-Index: 2
Last. Matthew D. Albaugh (UVM: University of Vermont)H-Index: 21
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The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with...
2 CitationsSource
#1Clare E. Palmer (University of California, Berkeley)H-Index: 11
#2Diliana Pecheva (UCSD: University of California, San Diego)H-Index: 5
Last. Anders M. DaleH-Index: 166
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During late childhood behavioral changes, such as increased risk-taking and emotional reactivity, have been associated with the maturation of cortico-subcortical circuits. null Understanding microstructural changes in subcortical regions may aid our understanding of how individual differences in these behaviors emerge. null Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted imaging that decomposes the diffusion signal from a voxel into hindered and restricted comp...
#1Clare E. Palmer (University of California, Berkeley)H-Index: 11
#2Diliana Pecheva (UCSD: University of California, San Diego)H-Index: 5
Last. Anders M. DaleH-Index: 166
view all 0 authors...
Development in late childhood has been associated with microstructural changes in white matter (WM) that are hypothesized to underpin concurrent changes in cognitive and behavioral function. Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted imaging that can probe microstructural changes within hindered and restricted compartments providing greater specificity than diffusion tensor imaging for characterizing intracellular diffusion. Using RSI, we modelled voxelwis...
#1Yi Li (UCSF: University of California, San Francisco)H-Index: 94
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
Last. Sandra A. Brown (UCSD: University of California, San Diego)H-Index: 124
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Importance Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to findings requiring urgent medical intervention. In the case of brain magnetic resonance imaging (MRI), reliable data about the prevalence and significance of IFs in the general population are limited, making it difficult to anticipate, communicate, and manage these findings. Objectives To determine the overall prevalence of IFs in brain MRI in the nonclinical...
#1R. J. LoughnanH-Index: 4
#2Alexey A. ShadrinH-Index: 12
Last. Anders M. DaleH-Index: 2
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Genome-Wide Association studies have typically been limited to single phenotypes, given that high dimensional phenotypes incur a large multiple comparisons burden: ~1 million tests across the genome times the number of phenotypes. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement in power t...
#1Clare E. Palmer (UCSD: University of California, San Diego)H-Index: 11
#2Weiqi Zhao (UCSD: University of California, San Diego)H-Index: 5
Last. Terry L. JerniganH-Index: 101
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Cognitive performance in children is predictive of academic and social outcomes; therefore, understanding neurobiological mechanisms underlying individual differences in cognition during development may be important for improving quality of life. The belief that a single, psychological construct underlies many cognitive processes is pervasive throughout society. However, it is unclear if there is a consistent neural substrate underlying many cognitive processes. Here, we show that a distributed ...
#1R. J. Loughnan (University of California, Berkeley)H-Index: 4
#2Clare E. Palmer (University of California, Berkeley)H-Index: 11
Last. Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
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Background: Findings in adults have shown more culturally sensitive 9crystallized9 measures of intelligence have greater heritability, these results were not able to be shown in children. Methods: With data from 8,518 participants, aged 9 to 11, from the Adolescent Brain Cognitive Development (ABCD) Study®, we used polygenic predictors of intelligence test performance (based on genome-wide association meta-analyses of data from 269,867 individuals) and of educational attainment (based on data fr...
6 CitationsSource
#1Merel Postema (MPG: Max Planck Society)H-Index: 5
#2Martine HoogmanH-Index: 32
Last. Clyde Francks (MPG: Max Planck Society)H-Index: 57
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OBJECTIVE: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. METHODS: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were cal...