Shuichi Kaneko
Kanazawa University
Internal medicineEndocrinologyPathologyOncologyGene expressionMolecular biologyVirologyCardiologyChemistryImmunologyHepatitis C virusInflammationType 2 diabetesInsulin resistanceHepatocellular carcinomaHepatitis B virusCancer researchDiabetes mellitusMedicineBiologyImmune systemGastroenterology
957Publications
104H-index
25.7kCitations
Publications 960
Newest
#1Yoshio Sakai (Kanazawa University)H-Index: 29
#2Alessandro Nasti (Kanazawa University)H-Index: 6
Last. Takuro Tamura (University of Tsukuba)
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Blood circulates throughout the body via the peripheral tissues, contributes to host homeostasis and maintains normal physiological functions, in addition to responding to lesions. Previously, we revealed that gene expression analysis of peripheral blood cells is a useful approach for assessing diseases such as diabetes mellitus and cancer because the altered gene expression profiles of peripheral blood cells can reflect the presence and state of diseases. However, no chronological assessment of...
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#1Nobuhiko Asakura (Osaka University)H-Index: 3
Last. Takashi Suzuki (Osaka University)H-Index: 28
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Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Additionally, the efficacy of targeted molecular therapies with multiple tyrosine kinase inhibitors is limited. In this study, we focused on the cellular signaling pathways common to diverse HCC cells and used quantitative reverse phase protein array (RPPA) and statistical analyses to elucidate the molecular mechanisms determining its malignancy. We examined the heterogeneity of 17 liver cancer cell lines by per...
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#1Takeshi Terashima (Kanazawa University)H-Index: 16
Last. Shuichi Kaneko (Kanazawa University)H-Index: 104
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AIM To examine the treatment patterns and medical costs in real-world practice among patients who received hepatectomy for hepatocellular carcinoma (HCC) in Japan. METHODS Data of patients who underwent hepatectomy as an initial therapy for primary HCC were extracted from a Japanese medical claims database from April 2008 to December 2019. The types of additional treatments for recurrent HCC and medical costs for up to 3 years from the first hepatectomy were analyzed. The average cumulative cost...
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#1Kazunori Kawaguchi (Kanazawa University)H-Index: 13
#2Yoshio Sakai (Kanazawa University)H-Index: 29
Last. Kuniaki Arai (Kanazawa University)H-Index: 25
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ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome, which includes diabetes mellitus and hyperlipidemia. A fraction of NAFLD patients develop nonalcoholic steatohepatitis, leading to cirrhosis associated with various serious complications, including hepatocellular carcinoma, gastroesophageal varices, cardiovascular events, and other organ malignancy. Although the incidence of chronic viral hepatitis with associated complications has gradually decreased as hig...
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#1Tomoyuki Hayashi (Kanazawa University)H-Index: 8
#2Yoshiro Asahina (Kanazawa University)H-Index: 6
Last. Shuichi Kaneko (Kanazawa University)H-Index: 104
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Salvage photodynamic therapy with talaporfin sodium has a high local control rate for esophageal cancer after definitive chemoradiotherapy. The eligibility criteria for photodynamic therapy include the absence of invasion to the cervical esophagus and a 3 cm maximum longitudinal lesion length. There is little evidence regarding the efficacy and safety of lesions outside the eligibility criteria. This retrospective cohort study evaluated the efficacy and safety of photodynamic therapy of such les...
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#1Kazuki Nagai (Kanazawa University)H-Index: 4
#2Tatsuya Yamashita (Kanazawa University)H-Index: 43
Last. Kuniaki Arai (Kanazawa University)H-Index: 25
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#1Takayoshi Shirasaki (Kanazawa University)H-Index: 16
#2Kazuhisa Murai (Kanazawa University)H-Index: 6
Last. Yoshio Sakai (Kanazawa University)H-Index: 29
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A syngeneic mouse model bearing a transplanted tumor is indispensable for the evaluation of the efficacy of immune checkpoint inhibitors (ICIs). However, few syngeneic mouse models of liver cancer are available. We established liver tumor cell lines (MHCF1 and MHCF5) from hepatitis C virus transgenic mice fed an atherogenic high-fat diet. MHCF1 and MHCF5 were successfully transplanted into the subcutaneous space of syngeneic C57BL/6 mice, in addition, they efficiently developed orthotopic tumors...
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#1Hiroki Matsukawa (Kanazawa University)
#2Noriho Iida (Kanazawa University)H-Index: 11
Last. Yoshio Sakai (Kanazawa University)H-Index: 29
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Microbiota in the gut and oral cavities of pancreatic cancer (PC) patients differ from those of healthy persons, and bacteria in PC tissues are associated with patients' prognoses. However, the species-level relationship between a dysbiotic gut, oral and cancerous microbiota, and prognostic factors remains unknown. Whole-genome sequencing was performed with fecal DNA from 24 PC patients and 18 healthy persons (HD). Microbial taxonomies, metabolic pathways, and viral presence were determined. DNA...
#1Takeshi OkanoueH-Index: 67
#2Toshihide ShimaH-Index: 19
Last. Shuichi Kaneko (Kanazawa University)H-Index: 104
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Aim null To develop a novel noninvasive test using an artificial intelligence (AI)/neural network (NN) system (named Fibro-Scope) to determine the fibrosis stage in nonalcoholic steatohepatitis (NASH). null Methods null 324 and 110 patients with histologically diagnosed NAFLD were enrolled for training and validation studies, respectively. Two independent pathologists histologically diagnosed patients with NAFLD for the validation study. Fibro-Scope was conducted using 12 items: age, sex, height...
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Abstract null null Adipose tissue-derived stem cells (ADSCs) have been suggested as a novel treatment for non-alcoholic steatohepatitis (NASH); however, the mechanisms underlying their therapeutic effect remain poorly understood. In this study, we aimed to investigate the association of Notch signaling, which is crucial for cellular proliferation and differentiation in ADSC-mediated treatment of NASH. Flow cytometry analysis of ADSCs showed that they expressed the Notch ligands JAG1, DLL1, and D...
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