Najib M. Rahman
University of Oxford
Internal medicineRadiologySurgeryEffusionRandomized controlled trialIntensive care medicineMalignant pleural effusionPleural diseasePleurodesisMesotheliomaLungEmpyemaPneumothoraxThoracoscopyMalignancyPleural effusionPopulationPleural infectionIn patientClinical trialMedicine
431Publications
46H-index
5,541Citations
Publications 446
Newest
#1Sarah L. Finnegan (University of Oxford)H-Index: 5
#2Olivia K. Harrison (University of Otago)H-Index: 3
Last. Najib M. Rahman (University of Oxford)H-Index: 46
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Rationale: For people with Chronic Obstructive Pulmonary Disease (COPD), improvements in breathlessness from pulmonary rehabilitation are neither long lasting nor guaranteed. Previously, we showed that pulmonary rehabilitation induced brain activity changes akin to those seen in exposure based cognitive behavioural therapies (CBT) in other conditions. null D-cycloserine is a partial NMDA-receptor agonist which has been shown to enhance CBT. Objectives: Here, we tested whether D-cycloserine would...
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#1Rachelle Asciak (Churchill Hospital)H-Index: 7
#2Nikolaos I. Kanellakis (Churchill Hospital)H-Index: 12
Last. Stephen Montefort (Mater Dei Hospital)H-Index: 29
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BACKGROUND Most patients with malignant pleural mesothelioma (MPM) present with malignant pleural effusion (MPE). There is in vitro evidence that MPE may not be a simple bystander of malignancy, but potentially has biological properties improving cancer cell survival and promoting cancer progression. If this is the case, MPE management may need to shift from current symptomatic strategies to aggressive fluid removal to impact on survival. RESEARCH QUESTION Is there an association between pleural...
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#1Anna BibbyH-Index: 3
Last. Nick A MaskellH-Index: 51
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#1Anand Sundaralingam (University of Oxford)H-Index: 1
#1Anand Sundaralingam (University of Oxford)H-Index: 2
Last. Najib M. Rahman (University of Oxford)H-Index: 46
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Pleural infection is a millennia-spanning condition that has proved challenging to treat over many years. Fourteen percent of cases of pneumonia are reported to present with a pleural effusion on chest X-ray (CXR), which rises to 44% on ultrasound but many will resolve with prompt antibiotic therapy. To guide treatment, parapneumonic effusions have been separated into distinct categories according to their biochemical, microbiological and radiological characteristics. There is wide variation in ...
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#1Eihab O. Bedawi (University of Oxford)H-Index: 5
#2Thomas Moore (University of Oxford)H-Index: 1
Last. Najib M. Rahman (University of Oxford)H-Index: 46
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A 45-year-old Caucasian woman was referred for investigation of recurrent chest infections. She had been treated over the previous 9 months for recurrent symptoms characterised by intermittent episodes of dyspnoea, cough productive of green sputum and pleuritic chest pain. Systemic enquiry was unremarkable; specifically, she had not experienced any weight loss or anorexia. On each episode, oxygen saturations were >94% and heart rate was <100 beats/min, with a single occurrence of a low-grade fev...
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#1Rachelle AsciakH-Index: 7
Last. Ioannis PsallidasH-Index: 24
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Objectives Patients with malignant pleural mesothelioma (MPM) or pleural metastases often present with malignant pleural effusion (MPE). This study aimed to analyze the effect of pleural fluid on cancer cells. Materials and methods Established patient-derived cancer cell cultures derived from MPE (MPM, breast carcinoma, lung adenocarcinoma) were seeded in 100% pleural fluid (exudate MPM MPE, transudate MPE, non-MPE transudate fluid) and proliferation was monitored. In addition, the establishment...
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#1Sarah L. Finnegan (University of Oxford)H-Index: 5
#2Olivia K. Harrison (University of Oxford)H-Index: 3
Last. Kyle T.S. Pattinson (University of Oxford)H-Index: 23
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Rationale Current models of breathlessness often fail to explain disparities between patients9 experiences of breathlessness and objective measures of lung function. While a mechanistic understanding of this discordance has thus far remained elusive, factors such as mood, attention and expectation have all been implicated as important modulators of breathlessness. Therefore, we have developed a model to better understand the relationships between these factors using unsupervised machine learning...
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#1Christian B. Laursen (University of Southern Denmark)H-Index: 13
#2Ole Graumann (University of Southern Denmark)H-Index: 9
Last. Najib M. Rahman (University of Oxford)H-Index: 46
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#1Siao Nge Hoon (Curtin University)H-Index: 2
#2Iain Lawrie (University of Manchester)H-Index: 5
Last. Fraser Brims (Curtin University)H-Index: 18
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Objective:Malignant Pleural Mesothelioma (MPM) has a poor prognosis and high symptom burden. RESPECT-Meso was a multicenter randomized study examining the role of early specialist palliative care (...
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