Melinda E. Sanders
Vanderbilt University
CancerInternal medicinePathologyOncologyImmunologyImmunohistochemistryMetastatic breast cancerBiopsyChemotherapyImmunotherapyLetrozoleMetastasisTriple-negative breast cancerCancer researchBreast cancerBioinformaticsMedicineEstrogen receptorPI3K/AKT/mTOR pathwayBiologyImmune system
Publications 213
#1Brian D. Lehmann (VUMC: Vanderbilt University Medical Center)H-Index: 33
#2Antonio Colaprico (UM: University of Miami)H-Index: 23
Last. Justin M. Balko (VUMC: Vanderbilt University Medical Center)H-Index: 56
view all 15 authors...
Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes include two basal-like (BL1, BL2), a mesenchymal (M) and a luminal androgen receptor (LAR) subtype. Through a comprehensive analysis of mutation, copy number, transcriptomic, epigenetic, proteomic, and phospho-proteomic patterns we describe the genomic landscape of TNBC subtypes. Mesenchymal subtype tumors display...
#1Clayton B. Marshall (Vandy: Vanderbilt University)H-Index: 7
#2J. Scott Beeler (Vandy: Vanderbilt University)H-Index: 8
Last. Jennifer A. Pietenpol (VUMC: Vanderbilt University Medical Center)H-Index: 76
view all 8 authors...
p73 and p63 are members of the p53 family that exhibit overlapping and distinct functions in development and homeostasis. The evaluation of p73 and p63 isoform expression across human tissue can provide greater insight to the functional interactions between family members. We determined the mRNA isoform expression patterns of TP73 and TP63 across a panel of 36 human tissues and protein expression within the highest-expressing tissues. TP73 and TP63 expression significantly correlated across tiss...
#1Paula I. Gonzalez-Ericsson (VUMC: Vanderbilt University Medical Center)H-Index: 13
#2Julia D Wulfkhule (GMU: George Mason University)H-Index: 1
Last. Melinda E. Sanders (VUMC: Vanderbilt University Medical Center)H-Index: 59
view all 15 authors...
Purpose: null Immunotherapies targeting PD-1/L1 enhance pathologic complete response (pCR) rates when added to standard neoadjuvant chemotherapy (NAC) regimens in early-stage triple-negative, and possibly high-risk estrogen receptor–positive breast cancer. However, immunotherapy has been associated with significant toxicity, and most patients treated with NAC do not require immunotherapy to achieve pCR. Biomarkers discerning patients benefitting from the addition of immunotherapy from those who ...
#7D. Marc Rosen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 10
Intratumor heterogeneity is an important mediator of poor outcomes in many cancers, including breast cancer. Genetic subclones frequently contribute to this heterogeneity, however their growth dynamics and interactions remain poorly understood. PIK3CA and HER2 alterations are known to co-exist in breast and other cancers. Herein, we present data that describe the ability of oncogenic PIK3CA mutant cells to induce the proliferation of quiescent HER2 mutant cells through a cell-contact mediated me...
#1Giju Thomas (Vandy: Vanderbilt University)H-Index: 10
#2Emmanuel A. Mannoh (Vandy: Vanderbilt University)H-Index: 3
Last. Anita Mahadevan-Jansen (Vandy: Vanderbilt University)H-Index: 48
view all 7 authors...
Identifying parathyroid glands can be challenging for surgeons during head and neck operations. For the surgeon, it becomes essential to preserve healthy parathyroid glands, while successfully removing diseased parathyroid glands. This study presents PTeye – a commercial fiber probe-based device that was designed for intraoperative parathyroid identification by detecting near infrared autofluorescence. The results of this study demonstrate that PTeye had 95% accuracy in identifying parathyroid g...
#1Margaret L AxelrodH-Index: 9
Last. Justin M. BalkoH-Index: 56
view all 11 authors...
#1Ann Hanna (VUMC: Vanderbilt University Medical Center)
Last. Justin M. BalkoH-Index: 56
view all 5 authors...
The breast cancer microenvironment comprises a complex stroma including tumor-infiltrating lymphocytes (TILs), which can either stimulate tumor progression or promote anti-tumor immunity in response to tumor-derived cues. In general, of all clinical subtypes, triple-negative breast cancer (TNBC) is characterized by the most extensive infiltration of TILs within tumor stroma, which is consistent with the observation that TNBC seems to clinically respond to immunotherapies at the highest rates. Im...
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