Quanyi Guo
Chinese PLA General Hospital
Biomedical engineeringStem cell transplantation for articular cartilage repairRegeneration (biology)ChemistryExtracellular matrixDecellularizationMaterials scienceMesenchymal stem cellOsteoarthritisArticular cartilage repairMeniscus (anatomy)CartilageStem cellTransplantationChondrogenesisTissue engineeringMedicineBiologyScaffoldCell biology
134Publications
27H-index
2,234Citations
Publications 127
Newest
#1Mingxue Chen (Chinese PLA General Hospital)H-Index: 12
#2Yangyang Li (PKU: Peking University)H-Index: 9
Last. Quanyi Guo (Chinese PLA General Hospital)H-Index: 27
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Abstract Tissue engineering provides a promising avenue for treating cartilage defects. However, great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration. In this study, decellularized cartilage extracellular matrix (ECM) and waterborne polyurethane (WPU) were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing (LDM) system, which combines rapid depos...
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#1Yu Yang (Guangxi Medical University)
#2Xin Wang (Chinese PLA General Hospital)H-Index: 6
Last. Jinmin Zhao (Guangxi Medical University)H-Index: 29
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Xenogeneic porcine fibrin sealant (PFS), derived from porcine blood, was used as a scaffold for cartilage tissue engineering. PFS has a porous microstructure, biocompatibility and degradation, and it provides a perfect extracellular matrix environment for the adhesion and proliferation of chondrocytes. Recently, PFS in combination with autologous chondrocytes (ACs) were used to study the microstructure of PFS scaffolds and promotion effect on the proliferation and migration of ACs. In this study...
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#1Liyun Wang (Sichuan University)H-Index: 8
#2Bihui Zhu (Sichuan University)H-Index: 5
Last. Li Qiu (Sichuan University)H-Index: 14
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#1Zhen Yang (NKU: Nankai University)H-Index: 3
#2Tianyuan Zhao (NKU: Nankai University)H-Index: 1
Last. Quanyi Guo (NKU: Nankai University)H-Index: 27
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Articular cartilage (AC) lesions are fairly common but remain an obstacle for clinicians and researchers due to their poor self-healing capacity. Recently, a promising therapy based on the recruitment of autologous mesenchymal stem cells (MSCs) has been developed for the regeneration of full-thickness cartilage defects in the knee joint. In this study, a 3D-bioprinted difunctional scaffold was developed based on aptamer HM69-mediated MSC-specific recruitment and growth factor-enhanced cell chond...
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#1Fu Wei (University of South China)H-Index: 1
Last. Quanyi GuoH-Index: 27
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Biomaterials play a core role in cartilage repair and regeneration. The success or failure of an implanted biomaterial is largely dependent on host response following implantation. Host response has been considered to be influenced by numerous factors, such as immune components of materials, cytokines and inflammatory agents induced by implants. Both synthetic and native materials involve immune components, which are also termed as immunogenicity. Generally, the innate and adaptive immune system...
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#1Hao LiH-Index: 1
#1Hao Li (NKU: Nankai University)H-Index: 98
Last. Quanyi GuoH-Index: 27
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Meniscus tissue engineering (MTE) aims to fabricate ideal scaffolds to stimulate the microenvironment for recreating the damaged meniscal tissue. Indeed, favorable mechanical properties, suitable biocompatibility, and inherent chondrogenic capability are crucial in MTE. In this study, we present a composite scaffold by 3D printing a poly(e-caprolactone) (PCL) scaffold as backbone, followed by injection with the meniscus extracellular matrix (MECM), and modification with kartogenin (KGN)-loaded p...
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#1Haojiang Li (Chinese PLA General Hospital)H-Index: 3
#2Xiang Sui (Chinese PLA General Hospital)H-Index: 15
Last. Quanyi Guo (Chinese PLA General Hospital)H-Index: 27
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Osteosarcoma, a common malignant tumor in orthopedics, often has a very poor prognosis after lung metastasis. Immunotherapy has not achieved much progress in the treatment because of the characteristics of solid tumors and immune environment of osteosarcoma. The tumor environment is rather essential for sarcoma treatment. Our previous study demonstrated that heat shock proteins could be used as antitumor vaccines by carrying tumor antigen peptides, and we hypothesize that an anti-osteosarcoma ef...
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#1Guangzhao Tian (Chinese PLA General Hospital)H-Index: 2
#2Shuangpeng Jiang (Chinese PLA General Hospital)H-Index: 2
Last. Shuyun Liu (Chinese PLA General Hospital)H-Index: 20
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Cartilage regeneration is a complex physiological process. Synovial macrophages play a critical immunomodulatory role in the acute inflammatory response surrounding joint injury. Due to the contrasting differences and heterogeneity of macrophage, the phenotype of macrophages are the key determinants of the healing response after cartilage injury. Biomaterials derived from extracellular matrix have been used for the repair and reconstruction of a variety of tissues by modulating the host macropha...
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#1Weimin Guo (SYSU: Sun Yat-sen University)H-Index: 3
#1Weimin GuoH-Index: 16
Last. Quanyi GuoH-Index: 27
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Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells, meniscus regeneration remains a great challenge in clinic. In this study, we found decellularized meniscal extracellular matrix (MECM) preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells. Moreover, MECM significantly promoted meniscal fibrochondrocytes viability and proliferation, in...
1 CitationsSource
#1Yang Zhen (Chinese PLA General Hospital)H-Index: 1
Last. Quanyi Guo (NKU: Nankai University)H-Index: 27
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It remains scientifically challenging to regenerate injured cartilage in orthopedics. Recently, an endogenous cell recruitment strategy based on a combination of acellular scaffolds and chemoattractants to specifically and effectively recruit host cells and promote chondrogenic differentiation has brought new hope for in situ articular cartilage regeneration. In this study, a transforming growth factor-β3 (TGF-β3)-loaded biomimetic natural scaffold based on demineralized cancellous bone (DCB) an...
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