Mark W. Logue
Boston University
GeneGenome-wide association studyPsychiatryInternal medicineSNPGenetic linkageOncologySingle-nucleotide polymorphismPsychologyNeuroscienceCognitionGenetic associationDNA methylationDiseasePosttraumatic stressEpigeneticsGeneticsApolipoprotein EClinical psychologyMedicineLocus (genetics)Biology
163Publications
33H-index
3,878Citations
Publications 157
Newest
#1Jennifer A. Sumner (UCLA: University of California, Los Angeles)H-Index: 27
#2Adam X. Maihofer (UCSD: University of California, San Diego)H-Index: 22
Last. Bekh Bradley (Emory University)H-Index: 66
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Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Heal...
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#1Mark W. LogueH-Index: 33
#2Clara SnijdersH-Index: 2
Last. Alicia K. SmithH-Index: 53
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#1Jena N Moody (OSU: Ohio State University)H-Index: 1
#2Kate E Valerio (OSU: Ohio State University)
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Body mass index (BMI) is a risk factor for Alzheimer's disease (AD) although the relationship is complex. Obesity in midlife is associated with increased risk for AD, whereas evidence supports both higher and lower BMI increasing risk for AD in late life. This study examined the influence of individual differences in genetic risk for AD to further clarify the relationship between late-life BMI and conversion to AD. Participants included 52 individuals diagnosed as having mild cognitive impairmen...
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#1Danielle R. Sullivan (BU: Boston University)H-Index: 7
#2Mark W. Miller (BU: Boston University)H-Index: 62
Last. David H. Salat (VA Boston Healthcare System)H-Index: 77
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Due to the use of improvised explosive devices, blast exposure and mild traumatic brain injury (mTBI) have become hallmark injuries of the Iraq and Afghanistan wars. Although the mechanisms of the ...
1 CitationsSource
#1Thomas Wooten (Tufts University)H-Index: 4
#1Thomas Wooten (Tufts University)
Last. Michael Esterman (VA Boston Healthcare System)H-Index: 27
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Objectives: Recent studies suggest that close-range blast exposure (CBE), regardless of acute concussive symptoms, may have negative long-term effects on brain health and cognition; however, these effects are highly variable across individuals. One potential genetic risk factor that may impact recovery and explain the heterogeneity of blast injury’s long-term cognitive outcomes is the inheritance of an apolipoprotein (APOE) e4 allele, a well-known genetic risk factor for Alzheimer’s disease. We ...
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#1Gopalkumar Rakesh (Duke University)H-Index: 8
Last. Rajendra A. MoreyH-Index: 34
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Introduction - Cortical thickness (CT) and surface area (SA) are established biomarkers of brain pathology in posttraumatic stress disorder (PTSD). Structural covariance networks (SCN) constructed from CT and SA may represent developmental associations, or unique interactions between brain regions, possibly influenced by a common causal antecedent. The ENIGMA-PGC PTSD Working Group aggregated PTSD and control subject data from 29 cohorts in five countries (3439). Methods - Using Destrieux Atlas,...
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#1Erika J. Wolf (VA Boston Healthcare System)H-Index: 36
#3Ci-Di Chen (BU: Boston University)H-Index: 23
Last. Mark W. Logue (VA Boston Healthcare System)H-Index: 33
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This study examined the klotho (KL) longevity gene polymorphism rs9315202 and psychopathology, including posttraumatic stress disorder (PTSD), depression, and alcohol-use disorders, in association with advanced epigenetic age in three postmortem cortical tissue regions: dorsolateral and ventromedial prefrontal cortices and motor cortex. Using data from the VA National PTSD Brain Bank (n = 117), we found that rs9315202 interacted with PTSD to predict advanced epigenetic age in motor cortex among ...
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#1Thomas Wooten (Tufts University)H-Index: 4
#2Emma M. Brown (VA Boston Healthcare System)H-Index: 1
Last. Michael EstermanH-Index: 27
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Abstract Elevated serum C-reactive protein (CRP) and possessing an APOE e4 allele are two of the most prominent risk factors for cognitive and neurological dysfunction in older adults, but little is known about the unique or cumulative effects of these risk factors in young-to-middle aged adults. To further characterize these potential relationships, measures of cognition and microstructural white matter integrity were examined using data from a sample of 329 post-9/11 war veterans that was coll...
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