Kiyoshi Teshigawara
Okayama University
GeneInternal medicineEndocrinologyGlycationMolecular biologyProinflammatory cytokineReceptorChemistryImmunologyHistidine-rich glycoproteinInflammationSepsisInsulinHMGB1Cancer researchBiochemistryMedicineBiologyCell biologyPharmacology
77Publications
18H-index
902Citations
Publications 76
Newest
#1Yohei TakahashiH-Index: 2
#2Hidenori WakeH-Index: 17
Last. Masahiro NishiboriH-Index: 51
view all 7 authors...
Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein and maintains the homeostasis of blood cells and vascular endothelial cells. In the current study, we demonstrate that HRG and recombinant HRG concentration dependently induced the phagocytic activity of isolated human neutrophils against fluorescence-labeled Escherichia coli and Staphylococcus aureus through the stimulation of CLEC1A receptors, maintaining their spherical round shape. The phagocytosis-inducing effects of HRG ...
1 CitationsSource
#1Kazuki Hatayama (Brown University)H-Index: 3
#1Kazuki Hatayama (Brown University)
Last. Barbara S. Stonestreet (Brown University)H-Index: 35
view all 12 authors...
The high-mobility group box-1 (HMGB1) protein is a transcription-regulating protein located in the nucleus. However, it serves as a damage-associated molecular pattern protein that activates immune cells and stimulates inflammatory cytokines to accentuate neuroinflammation after release from damaged cells. In contrast, Inter-alpha Inhibitor Proteins (IAIPs) are proteins with immunomodulatory effects including inhibition of pro-inflammatory cytokines. We have demonstrated that IAIPs exhibit neuro...
Source
#1Kiyoshi Teshigawara (Okayama University)H-Index: 18
#2Keyue Liu (Okayama University)H-Index: 25
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 7 authors...
Source
#1Shuji Mori (Shujitsu University)H-Index: 17
#2Masahiro Watanabe (Shujitsu University)H-Index: 7
Last. Takao Toyomura (Shujitsu University)H-Index: 2
view all 8 authors...
Source
#1Yukinori Yoshii (Okayama University)H-Index: 3
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 6 authors...
Background: Histidine-rich glycoprotein (HRG) treatment ameliorated the survival rate of septic mice by suppressing excess immunothrombus formation. Although such findings suggested that HRG may be one of the most useful drugs for sepsis, obtaining a stable experimental system to standardize the HRG drug product is difficult to achieve using neutrophils isolated from volunteers. This is due to the short survival time and individual differences of human neutrophils. In the present study, we deter...
1 CitationsSource
#1Hidenori Wake (Okayama University)H-Index: 17
#2Yohei Takahashi (Okayama University)H-Index: 2
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 8 authors...
Sepsis is caused by infections associated with life-threatening multiple organ failure (MOF). Septic MOF appears to be closely related to circulatory failure due to immunothrombosis. This process i...
2 CitationsSource
#1Masahiro Watanabe (Shujitsu University)H-Index: 7
#2Takao Toyomura (Shujitsu University)H-Index: 2
Last. Shuji Mori (Shujitsu University)H-Index: 17
view all 9 authors...
Previously, we found that advanced glycation endproducts (AGEs) directly interact with tumor necrosis factor (TNF)-like weak inducer of apoptosis, a cytokine that controls inflammation, and that this interaction inhibited its action. This finding raised the novel possibility that AGEs alter the function of other cytokines through direct interaction. To investigate this possibility, we performed comprehensive screening for candidates that interacted with AGEs using protein array analysis. The arr...
Source
#1Shangze Gao (Okayama University)H-Index: 2
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 11 authors...
Summary High mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice through the regulation of neutrophils and endothelium barrier function. As the relationship of HRG and HMGB1 remains poorly understood, we investigated the effects of HRG on HMGB1-mediated pathway in endothelial cells, focusing on the involvement of specific recept...
5 CitationsSource
#1Dengli Wang (Okayama University)H-Index: 6
#2Keyue Liu (Okayama University)H-Index: 25
Last. Masahiro Nishibori (Okayama University)H-Index: 51
view all 8 authors...
High mobility group box-1 (HMGB1), a nonhistone chromatin DNA-binding protein, is released from neurons into the extracellular space under ischemic, hemorrhagic, and traumatic insults. However, the details of the time-dependent translocation of HMGB1 and the subcellular localization of HMGB1 through the release process in neurons remain unclear. In the present study, we examined the subcellular localization of HMGB1 during translocation of HMGB1 in the cytosolic compartment using a middle cerebr...
5 CitationsSource
#1Masahiro Watanabe (Shujitsu University)H-Index: 7
#2Takao Toyomura (Shujitsu University)H-Index: 2
Last. Shuji Mori (Shujitsu University)H-Index: 17
view all 8 authors...
: Advanced glycation end products (AGEs) are considered to be related to the pathogenesis of some inflammatory diseases. AGEs were reported to stimulate the receptor for AGEs (RAGE), which causes inflammatory reactions. However, recently, toll-like receptors (TLRs), in addition to RAGE, have been reported to be related to AGE-mediated cellular responses, and it remains unclear which receptor is responsible for AGE recognition. To reveal the role of pattern-recognition receptors, including TLRs a...
9 CitationsSource