Mingyi Wang
National Institutes of Health
Matrix metalloproteinaseInternal medicineEndocrinologyPathologyProinflammatory cytokineReceptorChemistryExtracellular matrixImmunologyMyocyteInflammationVascular smooth muscleElastinAortaCalcificationAngiotensin IISignal transductionMedicineBiologyCell biology
69Publications
28H-index
6,960Citations
Publications 67
Newest
#1Allen Sam Titus (Sree Chitra Thirunal Institute for Medical Sciences and Technology)H-Index: 2
#2Harikrishnan (Sree Chitra Thirunal Institute for Medical Sciences and Technology)H-Index: 2
Last. Shivakumar Kailasam (Sree Chitra Thirunal Institute for Medical Sciences and Technology)H-Index: 3
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Fibronectin is an extracellular matrix glycoprotein with a regulatory role in fundamental cellular processes. Recent reports on the cardioprotective effect of fibronectin inhibition in a setting of myocardial injury suggest a role for fibronectin in cardiac fibroblast function, which remains largely unexplored. This study probed the molecular basis and functional implications of fibronectin gene expression in cardiac fibroblasts exposed to Angiotensin II, a potent pro-fibrotic factor in the myoc...
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#1Soo Hyuk Kim (NIH: National Institutes of Health)H-Index: 10
#2Robert E. Monticone (NIH: National Institutes of Health)H-Index: 28
Last. Mingyi Wang (NIH: National Institutes of Health)H-Index: 28
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Abstract Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of t...
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#1Soo Hyuk Kim (NIH: National Institutes of Health)H-Index: 10
#2Lijuan Liu (NIH: National Institutes of Health)H-Index: 4
Last. Mingyi Wang (NIH: National Institutes of Health)H-Index: 28
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Abstract Objective The proinflammatory phenotypic shift of vascular smooth muscle cells (VSMCs) is closely linked to the elastolysis and calcification in the aging arterial wall. Degradation of tropoelastin (TPELN) is a key molecular event which often accompanies the proinflammatory phenotypic shift of VSMCs, arterial elastolysis and calcification with aging. Milk fat globule-EGF factor 8 (MFG-E8), secreted mainly from VSMCs, predominantly binds to degenerated elastin fibers, and alters VSMCs ph...
1 CitationsSource
#1Wenli Dai (U of C: University of Chicago)H-Index: 3
#2Rangarajan D. Nadadur (U of C: University of Chicago)H-Index: 6
Last. Christopher R. Weber (U of C: University of Chicago)H-Index: 40
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Rationale: Zona occludens 1 (ZO-1), encoded by the Tight Junction Protein 1 (TJP1) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap and adherens junction proteins, and localizes to intercalated discs in cardiomyocytes. However, the contribution of ZO-1 to cardiac physiology remains poorly defined. Objective: We aim to determine the role of ZO-1 in cardiac function. Methods and Results: Inducible cardiomyocyte-specific ...
3 CitationsSource
#1John Lammons (NIH: National Institutes of Health)
#2Kirill V. Tarasov (NIH: National Institutes of Health)H-Index: 23
Last. Edward G. Lakatta (NIH: National Institutes of Health)H-Index: 166
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#1Mingyi WangH-Index: 28
#2Robert E. MonticoneH-Index: 28
Last. Kimberly R. McGrawH-Index: 3
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Aging is a major risk factor for quintessential cardiovascular diseases, which are closely related to arterial proinflammation. The age-related alterations of the amount, distribution, and properties of the collagen fibers, such as cross-links and degradation in the arterial wall, are the major sequelae of proinflammation. In the aging arterial wall, collagen types I, II, and III are predominant, and are mainly produced by stiffened vascular smooth muscle cells (VSMCs) governed by proinflammator...
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#1Qingxun Hu (UW: University of Washington)H-Index: 11
#2Huiliang Zhang (UW: University of Washington)H-Index: 9
Last. Wang Wang (UW: University of Washington)H-Index: 19
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Rationale: Lipid overload-induced heart dysfunction is characterized by cardiomyocyte death, myocardial remodeling, and compromised contractility, but the impact of excessive lipid supply on cardia...
21 CitationsSource
#2Mingyi Wang (NIH: National Institutes of Health)H-Index: 28
Last. Shivakumar KailasamH-Index: 3
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Collagen accumulation and remodeling in the vascular wall is a cardinal feature of vascular fibrosis that exacerbates the complications of hypertension, aging, diabetes and atherosclerosis. With no specific therapy available to date, identification of mechanisms underlying vascular fibrogenesis is an important clinical goal. Here, we tested the hypothesis that Discoidin Domain Receptor 2 (DDR2), a collagen-specific receptor tyrosine kinase, is a determinant of arterial fibrosis. We report a sign...
4 CitationsSource
Background: Aging and dyslipidemia are major risk factors for atherosclerosis. Whether a longer dyslipidemia time at risk can account for this remains a conundrum. Methods and Results: Randomly cho...
#1Qingxun Hu (UW: University of Washington)H-Index: 11
#2Huiliang Zhang (UW: University of Washington)H-Index: 9
Last. Wang Wang (UW: University of Washington)H-Index: 19
view all 9 authors...
Rationale: Lipid overload can cause diabetic cardiomyopathy (DCM), which is characterized by cardiomyocyte death, myocardial remodeling, and eventually contractile dysfunction. How excessive lipid ...
1 CitationsSource