Louise Gallagher
Trinity College, Dublin
GeneGenome-wide association studyPsychiatryCopy-number variationPhenotypeSingle-nucleotide polymorphismPsychologyNeuroscienceCognitionAlleleAutismAutism spectrum disorderNeurodevelopmental disorderAttention deficit hyperactivity disorderPopulationGeneticsIntellectual disabilityCandidate geneClinical psychologyMedicineSchizophreniaBiology
155Publications
41H-index
14.3kCitations
Publications 155
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#1Sahar Avazzadeh (National University of Ireland, Galway)H-Index: 4
#2Leo R. Quinlan (NUI: National University of Ireland)H-Index: 21
Last. Jacqueline Fitzgerald (Trinity College, Dublin)H-Index: 8
view all 25 authors...
BACKGROUND NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated with excessive neuronal firing. NRXN1 encodes hundreds of presynaptic neuro-adhesion proteins categorized as NRXN1α/β/γ. Previous studies on cultured cells show that the short NRXN1β primarily exerts excitation effect, whereas the long NRXN1α which is more commonly deleted in pat...
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#1Thomas J. Dinneen (Trinity College, Dublin)
#2Fiana Ní Ghrálaigh (Trinity College, Dublin)H-Index: 1
Last. Louise Gallagher (Trinity College, Dublin)H-Index: 41
view all 5 authors...
Rare copy-number variants (CNVs) associated with neurodevelopmental disorders (NDDs), i.e., ND-CNVs, provide an insight into the neurobiology of NDDs and, potentially, a link between biology and clinical outcomes. However, ND-CNVs are characterised by incomplete penetrance resulting in heterogeneous carrier phenotypes, ranging from non-affected to multimorbid psychiatric, neurological, and physical phenotypes. Recent evidence indicates that other variants in the genome, or 'other hits', may part...
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#1Lauren SchwartzH-Index: 23
#2Assumpta CaixàsH-Index: 1
Last. Elizabeth Roof (Vandy: Vanderbilt University)H-Index: 13
view all 14 authors...
Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder associated with a characteristic behavioral phenotype that includes severe hyperphagia and a variety of other behavioral challenges such as temper outbursts and anxiety. These behaviors have a significant and dramatic impact on the daily functioning and quality of life for the person with PWS and their families. To date, effective therapies addressing these behavioral challenges have proven elusive, but several potential t...
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#1Bethany Oakley ('KCL': King's College London)H-Index: 5
#2Julian TillmannH-Index: 6
Last. Declan G. Murphy ('KCL': King's College London)H-Index: 111
view all 15 authors...
Background The global COVID-19 pandemic has had an unprecedented impact on European health and social care systems, with demands on testing, hospital and intensive care capacity exceeding available resources in many regions. This has led to concerns that some vulnerable groups, including autistic people, may be excluded from services. Methods We reviewed policies from 15 European member states, published in March–July 2020, pertaining to (1) access to COVID-19 tests; (2) provisions for treatment...
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#1Zhiqiang Sha (MPG: Max Planck Society)H-Index: 2
#2Daan van Rooij (Radboud University Nijmegen)H-Index: 22
Last. Clyde Francks (MPG: Max Planck Society)H-Index: 56
view all 59 authors...
Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls. Although these alterations affect multiple and widespread cortical regional asymmetries, the extent to which specific structural networks might be affected remains unknown. Inter-regional morphological covariance analysis can capture network connectivity relations between different cortical areas at t...
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#1Jacqueline Fitzgerald (Trinity College, Dublin)H-Index: 8
#2Louise Gallagher (Trinity College, Dublin)H-Index: 41
Chromosomal abnormalities are now considered a common cause of intellectual disability. With increased genetic testing, phenotyping and technological advancements, many new syndromes have been iden...
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#1Jacqueline Fitzgerald (Trinity College, Dublin)H-Index: 8
#2Charlotte Wilson (Trinity College, Dublin)H-Index: 12
Last. Louise GallagherH-Index: 41
view all 4 authors...
Abstract Background Chromosomal microarray (CMA) testing has been adopted as the first-tier diagnostic test for developmental disabilities. However, determining the clinical significance of the results is often complex. This qualitative study seeks to explore parental interpretation, adaption and coping in the context of ambiguous rare genetic findings in order to support parental adjustment and wellbeing. Methods In-depth interviews were conducted with parents (n = 30) of children identified wi...
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#1K. ConlanH-Index: 1
#2Jane McGrathH-Index: 17
Last. Louise Gallagher (Trinity College, Dublin)H-Index: 41
view all 6 authors...
OBJECTIVES To examine the rates of antipsychotic prescribing in the Irish paediatric and young adult population enrolled in the Irish General Medical Services Scheme pharmacy claims database from the Health Service Executive Primary Care Reimbursement Services database, with a focus on age and sex differences. To examine concomitant prescribing of certain other related medicines in this population. METHODS Data were obtained from the Irish General Medical Services (GMS) scheme pharmacy claims da...
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#1K. ConlanH-Index: 1
#2Louise GallagherH-Index: 41
Last. Jane McGrathH-Index: 17
view all 4 authors...
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