Noriaki Fukuhara
Tokyo Medical and Dental University
Internal medicineRadiologyEndocrinologySurgeryPathologyMagnetic resonance imagingRetrospective cohort studyImmunohistochemistryPathologicalCavernous sinusCushing's diseaseDiabetes insipidusCraniopharyngiomaTemozolomideAdenomaAcromegalyPituitary glandHypopituitarismPituitary adenomaCerebrospinal fluidTranssphenoidal surgeryContext (language use)RadiosurgeryEndoscopic endonasal surgeryPituitary neoplasmIn patientRadiation therapyHormoneMedicineBiologyGastroenterology
51Publications
17H-index
868Citations
Publications 51
Newest
#1Noriaki FukuharaH-Index: 17
#2Takeo Iwata (Niigata University of Pharmacy and Applied Life Sciences)H-Index: 19
Last. Hiroshi NishiokaH-Index: 19
view all 13 authors...
Craniopharyngioma (CP) is mainly classified into two pathological subtypes: adamantinomatous (ACP) and papillary (PCP). CTNNB1 (β-catenin) mutations are detected in ACPs, and the BRAF V600E mutation is detected in PCPs. However, genetic analysis is not always possible in general medical practice. In this study, we investigated whether immunohistochemistry could replace genetic analysis as an aid in subtype diagnosis. Here, 38 CP patients who had undergone their first tumor resection were include...
1 CitationsSource
#1Rie Nishio (Juntendo University)H-Index: 1
#2Akira TakeshitaH-Index: 108
Last. Yasuhiro TakeuchiH-Index: 64
view all 15 authors...
Male patients with acromegaly frequently have hypogonadism. However, whether excess GH affects gonadal function remains unclear. We retrospectively compared clinical features affecting total testosterone (TT) and free testosterone (FT) levels between 112 male patients with acromegaly and 100 male patients with non-functioning pituitary adenoma (NFPA) without hyperprolactinemia. Median maximum tumor diameter (14.4 vs. 26.5 mm) and suprasellar extension rate (33 vs. 100%) were lower in acromegaly,...
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Summary A 50-year-old woman with thyroid-stimulating hormone (TSH)-producing pituitary adenoma (TSHoma) was diagnosed due to symptoms of thyrotoxicosis. Preoperatively, she showed thyrotoxicosis with the syndrome of inappropriate secretion of TSH (SITSH) and had a 5 cm nodule in her thyroid gland. Octreotide was administered preoperatively, which helped lower her serum TSH level but not her thyroid hormone level. These findings were atypical for a patient with TSHoma. The TSHoma was completely r...
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#1Tetsuro Niri (Nagasaki University)H-Index: 2
#2Ichiro Horie (Nagasaki University)H-Index: 13
Last. Atsushi Kawakami (Nagasaki University)H-Index: 60
view all 12 authors...
Idiopathic hypothalamitis is a rare condition that can cause anterior pituitary dysfunction and central diabetes insipidus (CDI), occasionally accompanied by a disturbance of autonomic regulation known as hypothalamic syndrome. This condition has been described as a subtype of autoimmune (lymphocytic) hypophysitis; however, some cases of isolated hypothalamic involvement with no inflammatory lesions in either the pituitary gland or infundibulum have been reported. The detailed epidemiology and p...
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#1Keita TatsushimaH-Index: 1
#2Akira TakeshitaH-Index: 108
Last. Yasuhiro TakeuchiH-Index: 64
view all 7 authors...
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#1Shinsuke Uraki (Wakayama Medical University)H-Index: 5
#2Hiroyuki Ariyasu (Wakayama Medical University)H-Index: 11
Last. Takashi Akamizu (Wakayama Medical University)H-Index: 59
view all 11 authors...
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#1Shinsuke Uraki (Wakayama Medical University)H-Index: 5
#2Hiroyuki Ariyasu (Wakayama Medical University)H-Index: 11
Last. Takashi Akamizu (Wakayama Medical University)H-Index: 1
view all 13 authors...
Mismatch repair genes mutS homologs 6/2 (MSH6/2) expressions are involved in tumor growth and programmed cell death 1 ligand 1 (PD-L1) expression in tumor immunity, but the direct association with pituitary adenomas (PAs) is not well understood. We aimed to clarify the effects of MSH6/2 and PD-L1 expression on tumor proliferation and invasiveness in nonfunctioning (NF) PAs. We performed immunohistochemistry to classify the NFPAs into gonadotroph adenoma (GAs), silent corticotroph adenomas (SCAs)...
5 CitationsSource
#1Noriaki Fukuhara (Tokyo Medical and Dental University)H-Index: 17
#2Wataro TsurutaH-Index: 10
Last. Hiroshi NishiokaH-Index: 19
view all 10 authors...
: Precautious balloon test occlusion (BTO) is sometimes performed in cases of high-risk intraoperative internal carotid artery injury. We investigated whether magnetic resonance angiography (MRA) findings could predict BTO results to thus avoid the use of precautious BTO. This retrospective study, included 96 patients who underwent BTO, eight of whom underwent bilateral BTO. The relationship between the BTO results for 104 internal carotid arteries and the MRA findings obtained in 96 patients we...
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#1Noriaki Fukuhara (Tokyo Medical and Dental University)H-Index: 17
#2Naoko Inoshita (Tokyo Medical and Dental University)H-Index: 21
Last. Hiroshi NishiokaH-Index: 19
view all 9 authors...
: Pituitary adenoma has been reported to be detectable in only 36-63% of Cushing's disease (CD) patients by magnetic resonance imaging (MRI). In this study, we investigate the outcomes and problems associated with tumor identification using 3-Tesla (3-T) MRI, which provides clearer images than ≤1.5-T MRI, in 115 patients who were initially diagnosed with CD. Before surgery, 31 macroadenomas (27%) and 54 microadenomas (47%) were identified by 3-T MRI, but pituitary adenoma was invisible on MRI in...
6 CitationsSource
#1Nobuyuki KobayashiH-Index: 3
#1Nobuyuki KobayashiH-Index: 11
Last. Shozo YamadaH-Index: 38
view all 6 authors...
: Growth hormone deficiency (GHD) is an endocrine disorder characterized by insufficient production of growth hormone (GH). Non-functioning pituitary adenoma (NFPA) is one of common causes of GHD. Although most patients with NFPA have transsphenoidal surgery, the time-dependent changes in GH after operation have yet to be investigated. In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing pep...
3 CitationsSource