Ronald C. Chen
University of North Carolina at Chapel Hill
Quality of lifeCancerInternal medicineRadiologyUrologySurgeryOncologyPhysical therapyMedical physicsProstateAndrogen deprivation therapyDiseaseProstatectomyMEDLINEProstate cancerPopulationRadiation therapyFamily medicineMedicineCohort
335Publications
32H-index
4,376Citations
Publications 323
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#1Ronald C. Chen (UNC: University of North Carolina at Chapel Hill)H-Index: 32
#2Sabrina G. Prime (UNC: University of North Carolina at Chapel Hill)
Last. Aaron J. Katz (KU: University of Kansas)H-Index: 2
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ABSTRACT Prospective clinical trials have demonstrated the safety and efficacy of active surveillance for men with localized prostate cancer, but also suggested that inadequate surveillance may risk missing an opportunity for cure. We used data from a population-based cohort of active surveillance patients to examine the rigor of surveillance monitoring in the general population. Among 1,419 patients enrolled from 2011–2013 throughout the State of XXXXX in collaboration with the state cancer reg...
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#1Shivani Sud (UNC: University of North Carolina at Chapel Hill)H-Index: 4
#2Brandon C. Gerringer (UNC: University of North Carolina at Chapel Hill)
Last. Ronald C. Chen (UNC: University of North Carolina at Chapel Hill)H-Index: 32
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PURPOSE/OBJECTIVES It is well known that physicians under-ascertain chemotherapy-related toxicity compared to patient self-report. However, under-ascertainment in radiation therapy and characterization of patient groups at increased risk for under-ascertainment have not been examined. MATERIALS/METHODS As part of routine clinical care, 7 urinary and gastrointestinal symptoms were prospectively collected with both patient report (PROs) using the validated Prostate Cancer Symptom Indices, and phys...
1 CitationsSource
#1Angela B. Smith (UNC: University of North Carolina at Chapel Hill)H-Index: 19
#2Cleo A. Samuel (UNC: University of North Carolina at Chapel Hill)H-Index: 10
Last. Ronald C. Chen (UNC: University of North Carolina at Chapel Hill)H-Index: 32
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Abstract Objective To assess the feasibility of enrollment and collecting patient-reported outcome (PRO) data as part of routine clinical urologic care for bladder and prostate cancer patients and examine overall patterns and racial variations in PRO use and symptom reports over time. Subjects/Patients and Methods We recruited 76 patients (n = 29 Black and n = 47 White) with prostate or bladder cancer at a single, comprehensive cancer center. The majority of prostate cancer patients had intermed...
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Acute urinary toxicity is well-documented in individuals receiving post-prostatectomy radiation. However, dosimetric correlations between bladder dose and acute urinary symptoms in the post-prostatectomy setting have not been well-studied. We examined the relationship between bladder dosimetry and acute changes in individual urinary symptoms among men receiving post-prostatectomy radiation therapy. Patient-reported urinary symptoms were prospectively collected for 90 consecutive prostate cancer ...
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#1Xuanang Xu (UNC: University of North Carolina at Chapel Hill)H-Index: 4
Last. Dinggang ShenH-Index: 113
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Segmentation of the prostate bed, the residual tissue after the removal of the prostate gland, is an essential prerequisite for post-prostatectomy radiotherapy but also a challenging task due to its non-contrast boundaries and highly variable shapes relying on neighboring organs. In this work, we propose a novel deep learning-based method to automatically segment this “invisible target”. As the main idea of our design, we expect to get reference from the surrounding normal structures (bladder&re...
3 CitationsSource
#1Antonia V. Bennett (UNC: University of North Carolina at Chapel Hill)H-Index: 24
#2Mattias JonssonH-Index: 3
Last. Lesley H. CurtisH-Index: 74
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Abstract Patient-reported health data provide information for pragmatic clinical trials that may not be readily available from electronic health records or administrative claims data. In this report, we present key considerations for collecting patient-reported health information in pragmatic clinical trials, which are informed by best practices from patient-reported outcome research. We focus on question design and administration via electronic data collection platforms with respect to 3 types ...
1 CitationsSource
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#1Daniel O. Erim (UNC: University of North Carolina at Chapel Hill)H-Index: 8
#2Antonia V. Bennett (UNC: University of North Carolina at Chapel Hill)H-Index: 24
Last. Ronald C. Chen (UNC: University of North Carolina at Chapel Hill)H-Index: 32
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BACKGROUND: There are uncertainties about prostate cancer-related anxiety's (PCRA) associations with health-related quality of life (HRQOL) and major depression, and these could affect the quality of mental healthcare provided to prostate cancer patients. Addressing these uncertainties will provide more insight into PCRA and inform further research on the value of PCRA prevention. The goals of this study were to measure associations between PCRA and HRQOL at domain and subdomain levels, and to e...
3 CitationsSource