Sune H. Keller
Copenhagen University Hospital
Imaging phantomPhysicsCorrection for attenuationInternal medicineRadiologyBiomedical engineeringIterative reconstructionArtificial intelligenceTomographyNeuroscienceReceptorAttenuationImage resolutionPositron emission tomographyScannerNuclear medicineComputer visionComputer scienceVoxelImage qualityNeuroimagingMedicine
75Publications
18H-index
981Citations
Publications 75
Newest
#1Agata Casado-Sainz (Copenhagen University Hospital)H-Index: 3
#2Gudmundsen F (Copenhagen University Hospital)H-Index: 2
Last. Mikael Palner (Copenhagen University Hospital)H-Index: 3
view all 15 authors...
Dorsal striatal dopamine transmission engages the cortico-striato-thalamo-cortical (CSTC) circuit, which is implicated in many neuropsychiatric diseases, including obsessive-compulsive disorder (OCD). Yet it is unknown if dorsal striatal dopamine hyperactivity is the cause or consequence of changes elsewhere in the CSTC circuit. Classical pharmacological and neurotoxic manipulations of the CSTC and other brain circuits suffer from various drawbacks related to off-target effects and adaptive chan...
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#3Martin NørgaardH-Index: 10
#6Sune H. KellerH-Index: 18
Last. Melanie GanzH-Index: 11
view all 8 authors...
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#2Gudmundsen F (Copenhagen University Hospital)H-Index: 2
#7S. Medina (Copenhagen University Hospital)H-Index: 2
Nigro-striatal dopamine transmission in the rat dorsomedial striatum (DMS) engages the cortico-striato-thalamo-cortical (CSTC) circuit. Modulation of the CSTC circuit can emulate behavioral and functional aspects of neuropsychiatric diseases, including obsessive compulsive disorder (OCD). Classical pharmacological and neurotoxic manipulations of brain circuits suffer from various drawbacks related to off-target effects and adaptive changes. Chemogenetics, on the other hand, enables a highly sele...
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#7Peter S. Jensen (Copenhagen University Hospital)H-Index: 15
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. For decades, several in vivo and ex vivo techniques have been used to highlight the mechanisms of the GABA system, however, no studies have currently combined the techniques to create a high-resolution multimodal view of the GABA system. Here, we present a quantitative high-resolution in...
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Nigro-striatal dopamine transmission in the rat dorsomedial striatum (DMS) engages the cortico-striato-thalamo-cortical (CSTC) circuit. Modulation of the CSTC circuit can emulate behavioral and functional aspects of neuropsychiatric diseases, including obsessive compulsive disorder (OCD). Classical pharmacological and neurotoxic manipulations of brain circuits suffer from various drawbacks related to off-target effects and adaptive changes. Chemogenetics, on the other hand, enables a highly sele...
Source
#1Tine Nøhr Christensen (Copenhagen University Hospital)H-Index: 1
#2Seppo W. Langer (Copenhagen University Hospital)H-Index: 26
Last. Barbara M. Fischer (Copenhagen University Hospital)H-Index: 23
view all 8 authors...
Radiation-induced changes may cause a non-malignant high 2-deoxy-2-[18F]fluoro-d-glucose (FDG)-uptake. The 3′-deoxy-3′-[18F]fluorothymidine (FLT)-PET/CT performs better in the differential diagnosis of inflammatory changes and lung lesions with a higher specificity than FDG-PET/CT. We investigated the association between post-radiotherapy FDG-PET-parameters, FLT-PET-parameters, and outcome. Sixty-one patients suspected for having a relapse after definitive radiotherapy for lung cancer were inclu...
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#1Louise Møller Jørgensen (UCPH: University of Copenhagen)H-Index: 9
#2Tove Henriksen (Bispebjerg Hospital)H-Index: 11
Last. Gitte M. Knudsen (UCPH: University of Copenhagen)H-Index: 71
view all 11 authors...
Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, which may be caused by serotonergic dysfunction. Apart from alleviating the motor symptoms, Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non-motor symptoms. The aim of this study is to investigate how turning DBS off affects the serotonergic system. We here exploit a novel functional PET neuroimaging methodology to evaluate the preservation of serotonergic neurons and capacity to rele...
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#1Maria S. Svane (UCPH: University of Copenhagen)H-Index: 15
#2Helle Hjorth Johannesen (UCPH: University of Copenhagen)H-Index: 16
Last. Nicolai J. Wewer Albrechtsen (UCPH: University of Copenhagen)H-Index: 28
view all 16 authors...
AIMS Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used for treatment of type 2 diabetes and obesity. No definite link to pancreatitis or pancreatic cancer has been observed with GLP-1RAs, but plasma concentrations of lipase and amylase are increased during treatment. Expansion of the pancreatic volume due to increased DNA synthesis and/or protein synthesis was reported in rodents. We investigated the effect of a GLP-1RA, liraglutide, on pancreatic volume, edema, cellularity and DNA s...
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#1Hanne D. Hansen (Harvard University)H-Index: 17
#2Ulrich Lindberg (UCPH: University of Copenhagen)H-Index: 10
Last. Gitte M. Knudsen (UCPH: University of Copenhagen)H-Index: 71
view all 9 authors...
Endogenous serotonin (5-HT) release can be measured noninvasively using positron emission tomography (PET) imaging in combination with certain serotonergic radiotracers. This allows us to investigate effects of pharmacological and nonpharmacological interventions on brain 5-HT levels in living humans. Here, we study the neural responses to a visual stimulus using simultaneous PET/MRI. In a cross-over design, 11 healthy individuals were PET/MRI scanned with the 5-HT1B receptor radioligand [11 C]A...
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#1Maria S. SvaneH-Index: 15
view all 16 authors...
Plasma concentrations of the two pancreatic enzymes, amylase and lipase, are increased within the normal physiological range after initiation of glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment. An association between the use of GLR-1RA and incidence of acute pancreatitis or pancreatic cancer has not been found - neither in rodent studies nor in preclinical studies or in the large cardiovascular outcome trials with GLP-1RAs. The increased concentrations of pancreatic enzymes have bee...
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