Namiko Kawamura
Kagoshima University
Internal medicineEndocrinologyHippocampal formationAMPA receptorContraction (grammar)ReceptorAdipose tissueChemistryIn vivoExtracellular fluidEnergy homeostasisNatriuretic peptideHesperidinEndotheliumOrexigenicFlavanoneGlycogenAstrocyteRutinoseNeuronDiseaseAmygdalaStreptozotocinInsulinGhrelinMicrogliaSkeletal muscleVasoconstrictionContext (language use)Diet-induced obeseCorticosteroneLeptinPathogenesisHippocampusExtracellularGhrelin secretionCognitive declineSaturated fatCX3CR1MicrodialysisObesityCentral nervous systemBiochemistryNMDA receptorMedicineBlood pressureTropomyosin receptor kinase BPharmacology
6Publications
2H-index
21Citations
Publications 8
Newest
#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Ela Novianti (Kadai: Kagoshima University)H-Index: 1
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 7 authors...
The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucros...
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#1Ela Novianti (LIPI: Indonesian Institute of Sciences)H-Index: 1
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 5 authors...
Abstract null null Atractylenolide-III (AIII), a sesquiterpene compound isolated from the rhizome of Atractylodes macrocephala, has been reported to have anti-inflammatory effects in the peripheral organs. However, its effects on brain inflammation remain elusive. The present study investigated the effects of AIII on the response to lipopolysaccharide (LPS) in mouse microglia and clarified the underlying mechanism. In this study, treatment of MG6 cells with AIII (100 μM) significantly decreased ...
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#1Yuki Kambe (Kadai: Kagoshima University)H-Index: 15
#2Yu Yamauchi (Kadai: Kagoshima University)H-Index: 1
Last. Atsuro Miyata (Kadai: Kagoshima University)H-Index: 29
view all 14 authors...
BACKGROUND Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an essential role in the modulation of astrocyte functions. Although lactate secretion from astrocytes contributes to many forms of neuronal plasticity in the central nervous system, including fear learning and memory, the role of PACAP in lactate secretion from astrocytes is unclear. METHODS The amygdala and hippocampus of PACAP (+ / +) and PACAP (-/-) mice were acquired 1 h after memory acquisition and recall in the pa...
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#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akihiro Asakawa (Kadai: Kagoshima University)H-Index: 30
view all 6 authors...
Introduction A diet high in saturated fat is well known to affect neuronal function and contribute to cognitive decline in experimental animals and humans. Fractalkine released from neurons acts on its receptor, CX3C chemokine receptor 1 (CX3CR1), in the microglia to regulate several brain functions. The present study addressed whether fractalkine-CX3CR1 signaling in the brain, especially the hippocampus, contributes to the cognitive deficits observed in diet-induced obese (DIO) mice. Research d...
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#1Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
#2Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
Last. Akihiro Asakawa (Kadai: Kagoshima University)H-Index: 30
view all 6 authors...
Patients with diabetes mellitus are predisposed to cognitive impairment. Fractalkine-CX3CR1 in the brain signaling represents a primary neuron-microglia inter-regulatory system for several brain functions including learning and memory processes. The present study addressed whether fractalkine-CX3CR1 signaling in the hippocampus contributes to the cognitive deficits observed in streptozotocin (STZ)-treated mice. Our results showed that STZ-treated mice exhibited significant cognitive deficits in ...
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#1Hajime SuzukiH-Index: 7
#2Akihiro AsakawaH-Index: 30
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 5 authors...
Hesperidin, a flavanone glycoside consisting of the flavone hesperitin bound to the disaccharide rutinose, is found in highly nutritious foods, such as oranges, tangelos, tangerines, grapefruits, and other citrus fruits. Exogenous hesperidin has been shown to influence a wide variety of biological functions, including induction of apoptosis and suppression of proliferation in human cancer cells; inhibition of tumor development in various tissues; and expression of antibacterial, antiviral, and a...
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#1Goro Katsuura (Kadai: Kagoshima University)H-Index: 8
#2Namiko Kawamura (Kadai: Kagoshima University)H-Index: 2
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 6 authors...
Obesity is becoming a worldwide problem, as it is associated with serious comorbidities, including a high incidence of type II diabetes, cardiovascular disease and many forms of cancer. Obesity is defined as increased adipose mass resulting from chronic excess of energy intake over energy expenditure. Energy homeostasis including food intake and energy consumption has been demonstrated to be regulated predominantly by orexigenic and anorexigenic systems in the hypothalamus. The blood-born hormon...
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#1Yingxiao Li (Kadai: Kagoshima University)H-Index: 14
#2Kai-Chun Cheng (Kadai: Kagoshima University)H-Index: 22
Last. Akio Inui (Kadai: Kagoshima University)H-Index: 72
view all 9 authors...
Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family. Thus, musclin is found to bind with the natriuretic peptide clearance receptors. However, the role of musclin in vascular regulation remains unclear. In this study, we aim to investigate the direct effect of musclin on vascular tone and to analyze its role in hypertension using the spontaneously hype...
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