Kazuyoshi Kuwano
Jikei University School of Medicine
Internal medicinePathologyOncologyApoptosisImmunologyAutophagyLung cancerCOPDLungIdiopathic pulmonary fibrosisFibrosisPathogenesisPulmonary fibrosisLung injuryCancer researchSenescenceMedicineBiologyGastroenterologyCell biology
337Publications
58H-index
6,979Citations
Publications 332
Newest
#1Hideaki Yamakawa (Jikei University School of Medicine)H-Index: 10
#2Tamiko TakemuraH-Index: 43
Last. Hidekazu MatsushimaH-Index: 7
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We herein report four cases of diffuse bronchiolitis proven by a transbronchial lung cryobiopsy (TBLC). Based on various aspects, including the pathological findings, we definitively diagnosed two patients with diffuse panbronchiolitis (DPB) and the other two with primary ciliary dyskinesia (PCD). One of the DPB patients had more severe peribronchiolar fibrosis than the other, and the disease course was refractory to macrolide therapy. One of the PCD patients was additionally diagnosed with comb...
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#1Hiromichi Hara (Jikei University School of Medicine)H-Index: 21
#2Hanae Miyagawa (Jikei University School of Medicine)H-Index: 1
Last. Kazuyoshi Kuwano (Jikei University School of Medicine)H-Index: 58
view all 9 authors...
Interleukin (IL)-17 plays critical roles in the pathogenesis of both psoriasis and interstitial pneumonia (IP). We hypothesized that anti-IL-17 biologics might suppress both clinically relevant and latent IP activity and decrease Krebs von den Lungen-6 (KL-6) level in psoriasis patients. We aimed to elucidate the effects of anti-IL-17 biologics on KL-6 levels. We retrospectively analyzed the clinical data of psoriasis patients treated with anti-IL-17 biologics. KL-6 levels were measured before t...
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#1Kazuya Tone (Teikyo University)H-Index: 5
#2Takashi Tamura (Teikyo University)H-Index: 7
Last. Koichi MakimuraH-Index: 37
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#1Naoaki Watanabe (Jikei University School of Medicine)H-Index: 2
Last. Yusuke YamamotoH-Index: 38
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The development of high-throughput single-cell RNA sequencing (scRNA-seq) has provided a new research tool to obtain gene expression profiles at single-cell resolution and identify novel cellular phenotypes in lung diseases. To elucidate the cell-specific mechanisms contributing to COPD pathogenesis, we used scRNA-seq to dissect cellular and molecular features of COPD and elucidate differences in the proportions and transcriptional phenotypes of epithelial cells between COPD patients, non-COPD s...
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#1Yusuke Hosaka (Jikei University School of Medicine)H-Index: 4
#2Jun Araya (Jikei University School of Medicine)H-Index: 32
Last. Kazuyoshi Kuwano (Jikei University School of Medicine)H-Index: 58
view all 16 authors...
Introduction: Insufficient autophagic degradation has been implicated in accelerated cellular senescence during chronic obstructive pulmonary disease (COPD) pathogenesis. Cigarette smoke (CS)-induced functional deterioration of lysosomes may be associated with impaired autophagy. Lysosomal membrane permeabilization (LMP) is indicative of damaged lysosomes, and galectin-3 and tripartite motif proteins (TRIM)16 play a cooperative role in recognizing LMP and inducing lysophagy, a lysosome selective...
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#1Masafumi Sata (Jichi Medical University)H-Index: 4
#2Shinichi Sasaki (Juntendo University)H-Index: 14
Last. Kazuyoshi Kuwano (Jikei University School of Medicine)H-Index: 58
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Nivolumab, a human monoclonal antibody against programmed death-1, is approved for the treatment of non-small cell lung cancer (NSCLC). Although nivolumab is generally well tolerated, it can cause interstitial lung disease (ILD), a rare but potentially fatal immune-related adverse event. Currently, there are limited data available on the treatment of nivolumab-induced ILD and its outcome. This retrospective cohort study based on a post-marketing study described the treatment of nivolumab-induced...
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#1Yoshinobu Saito (Nippon Medical School)H-Index: 15
#2Shinichi Sasaki (Juntendo University)H-Index: 14
Last. Kazuyoshi Kuwano (Jikei University School of Medicine)H-Index: 58
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Nivolumab can cause interstitial lung disease (ILD), which may be fatal; however, mortality risk factors have not been identified. This postmarketing study evaluated the poor prognostic factors of ILD in nivolumab-treated patients with non-small cell lung cancer (NSCLC) in Japan. Clinical and chest imaging findings for each ILD case were assessed by an expert central review committee, and prognosis was evaluated by radiographic findings, including the presence/absence of peritumoral ground-glass...
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#1Shota FujimotoH-Index: 3
#2Yu FujitaH-Index: 24
Last. Kazuyoshi KuwanoH-Index: 58
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Respiratory diseases and their comorbidities, such as cardiovascular disease and muscle atrophy, have been increasing in the world. Extracellular vesicles (EVs), which include exosomes and microvesicles, are released from almost all cell types and play crucial roles in intercellular communication, both in the regulation of homeostasis and the pathogenesis of various diseases. Exosomes are of endosomal origin and range in size from 50-150 nm in diameter, while microvesicles are generated by the d...
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#1Sho Watanabe (Jikei University School of Medicine)H-Index: 4
#2Yasushi GotoH-Index: 18
Last. Yosuke TogashiH-Index: 27
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Background Patients with non-small cell lung cancer (NSCLC) harboring activating EGFR mutations are sensitive to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) but inevitably develop resistance to the inhibitors mostly through acquisition of the secondary T790M mutation. Although third-generation EGFR-TKIs overcome this resistance by selectively inhibiting EGFR with EGFR-TKI-sensitizing and T790M mutations, acquired resistance to third-generation EGFR-TKIs invariably dev...
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#1Hanae Miyagawa (Jikei University School of Medicine)H-Index: 1
#2Hiromichi Hara (Jikei University School of Medicine)H-Index: 21
Last. Kazuyoshi Kuwano (Jikei University School of Medicine)H-Index: 58
view all 9 authors...
Objectives Anti-IL-17/23 biologics are increasingly used to treat psoriasis. We aimed to elucidate characteristics of drug-induced interstitial pneumonia (DIIP) caused by anti-IL-17/23 biologics. Methods We retrospectively analyzed the clinical data of psoriasis patients treated with anti-IL-17/23 biologics. Chest CT was performed to evaluate DIIP. Serum KL-6 levels were measured before treatment (baseline) and during treatment. Results A total of 603 psoriasis patients were treated with anti-IL...
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