Catherine A. Gorrie
University of Technology, Sydney
AnatomyInternal medicineEndocrinologyNeural stem cellPathologyOlfactory ensheathing gliaNeuroscienceOccupational safety and healthInjury preventionNestinSpinal cord injuryDementiaCordSpinal cordLesionPopulationTransplantationPoison controlAnesthesiaCentral nervous systemMedicineGerontologyPharmacology
45Publications
16H-index
771Citations
Publications 46
Newest
#1Mawj Mandwie (UTS: University of Technology, Sydney)H-Index: 2
#2Jordan A Piper (UTS: University of Technology, Sydney)H-Index: 1
Last. Alessandro Castorina (UTS: University of Technology, Sydney)H-Index: 20
view all 7 authors...
Evidence suggests that rapid changes to supporting glia may predispose individuals with spinal cord injury (SCI) to such comorbidities. Here, we interrogated the expression of astrocyte- and microglial-specific markers glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba1) in the rat brain in the first 24 hours following SCI. Female Sprague-Dawley rats underwent thoracic laminectomy; half of the rats received a mild contusion injury at the level of the T10 v...
Source
#1Theresa Sutherland (UTS: University of Technology, Sydney)H-Index: 2
#2Alison Ricafrente (UTS: University of Technology, Sydney)H-Index: 2
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 5 authors...
It has been reported that children may respond better than adults to a spinal cord injury (SCI) of similar severity. There are known biomechanical differences in the developing spinal cord that may contribute to this "infant lesion effect," but the underlying mechanisms are unknown. Using immunohistochemistry, we have previously demonstrated a different injury progression and immune cell response after a mild thoracic contusion SCI in infant rats, as compared to adult rats. Here, we investigated...
Source
#1Razia Zakarya (UTS: University of Technology, Sydney)H-Index: 6
#2Arjun Sapkota (UTS: University of Technology, Sydney)H-Index: 1
Last. Hui Chen (UTS: University of Technology, Sydney)H-Index: 245
view all 9 authors...
Abstract Research has attributed tissue damage post-traumatic brain injury (TBI) to two-pronged effects, increased reactive oxygen species (ROS) and impairment of endogenous antioxidant defence systems, underpinned by manganese superoxide dismutase (MnSOD). Novel antioxidant nitroxides have been shown to mimic MnSOD to ameliorate oxidative stress related disorders. This project aims to investigate the effects of two nitroxides, CTMIO and DCTEIO, on the neurological outcomes following moderate TB...
Source
#1Tara Nguyen (UTS: University of Technology, Sydney)H-Index: 8
#2Gerard Li (UTS: University of Technology, Sydney)H-Index: 7
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 6 authors...
BACKGROUND: Maternal smoking is currently a public health concern and has been associated with a number of complications in the offspring. E-cigarettes are gaining popularity as a 'safer' alternative to tobacco cigarettes during pregnancy, however, there are a limited number of studies to suggest that it is actually 'safe'. STUDY DESIGN: Balb/C female mice were exposed to ambient air (n = 8; Sham), or tobacco cigarette smoke (n = 8; SE) before gestation, during gestation and lactation. A third g...
Source
#1Neus Gomila Pelegri (UTS: University of Technology, Sydney)H-Index: 1
#2Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
Last. Jerran Santos (UTS: University of Technology, Sydney)H-Index: 9
view all 3 authors...
Neural stem cells have become the focus of many studies as they have the potential to differentiate into all three neural lineages. This may be utilised to develop new and novel ways to treat neurological conditions such as spinal cord and brain injuries, especially if the stem cells can be modulated in vivo without additional invasive surgical procedures. This research is aimed at investigating the effects of the growth factors vascular endothelial growth factor, platelet-derived growth factor,...
Source
#1Hui Chen (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 245
#2Yik Lung Chan (UTS: University of Technology, Sydney)H-Index: 16
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 12 authors...
There is a need for pharmaceutical agents that can reduce neuronal loss and improve functional deficits following traumatic brain injury (TBI). Previous research suggests that oxidative stress and mitochondrial dysfunction play a major role in neuronal damage after TBI. Therefore, this study aimed to investigate two drugs known to have antioxidant effects, L-carnitine and exendin-4, in rats with moderate contusive TBI. L-carnitine (1.5 mM in drinking water) or exendin-4 (15 µg/kg/day, ip) were g...
Source
#1Tara Nguyen (UTS: University of Technology, Sydney)H-Index: 8
#2Gerard Li (UTS: University of Technology, Sydney)H-Index: 7
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 6 authors...
Electronic cigarette (e-cigarette) use is on the rise worldwide and is particularly attractive to young people and as a smoking substitute by pregnant woman. There is a perception in pregnant women and women of child-bearing age that the use of e-cigarettes (vaping) is safer than smoking tobacco cigarettes during pregnancy. However, there is little evidence to support this perception. Here, we examined the offspring from mouse dams that had been exposed during and after pregnancy to ambient air ...
Source
#1Ryan S. Tonkin (UNSW: University of New South Wales)H-Index: 7
#2Callum Bowles (UNSW: University of New South Wales)H-Index: 1
Last. Gila Moalem-Taylor (UNSW: University of New South Wales)H-Index: 24
view all 16 authors...
Abstract Connexin43 (Cx43) hemichannels in spinal cord astrocytes are implicated in the maintenance of neuropathic pain following peripheral nerve injury. Peptide5 is a Cx43 mimetic peptide that blocks hemichannels. In this study, we investigated the effects of spinal delivery of Peptide5 on mechanical pain hypersensitivity in two mouse models of neuropathic pain, peripheral nerve injury and chemotherapy-induced peripheral neuropathy (CIPN). We demonstrated that 10 days following a chronic const...
Source
#1Tara Nguyen (UTS: University of Technology, Sydney)H-Index: 8
#2Yilin Mao (UTS: University of Technology, Sydney)H-Index: 7
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 4 authors...
Traumatic spinal cord injury (SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells, astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI ( n = 9), sham...
Source
#1Printha Wijesinghe (USJP: University of Sri Jayewardenepura)H-Index: 1
#2Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
Last. K. Ranil D. De Silva (USJP: University of Sri Jayewardenepura)H-Index: 5
view all 11 authors...
Background: There is little information available in the literature concerning the contribution of dementia in injury deaths in elderly people (≥60 years). Aim: This study was intended to investigate the extent of dementia-related pathologies in the brains of elderly people who died in traffic accidents or by suicide and to compare our findings with age- and sex-matched natural deaths in an elderly population. Materials and Methods: Autopsy-derived human brain samples from nine injury death vict...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.