Hannah C. Glass
University of California, San Francisco
Magnetic resonance imagingNeurointensive careIntensive care medicinePediatricsProspective cohort studyCohort studyHypothermiaNeonatal encephalopathyEpilepsyGestational ageEncephalopathyNeonatal seizurePopulationHypoxic Ischemic EncephalopathySymptomatic seizuresIntensive careAnesthesiaElectroencephalographyMedicineCohort
115Publications
37H-index
3,832Citations
Publications 111
Newest
#1Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
#2Courtney J. Wusthoff (Stanford University)H-Index: 28
Last. Cameron Thomas (UC: University of Cincinnati)H-Index: 8
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OBJECTIVE We aimed to evaluate early-life epilepsy incidence, seizure types, severity, risk factors, and treatments among survivors of acute neonatal seizures. METHODS Neonates with acute symptomatic seizures born 7/2015-3/2018 were prospectively enrolled at nine Neonatal Seizure Registry sites. One-hour EEG was recorded at age three months. Post-neonatal epilepsy and functional development (Warner Initial Developmental Evaluation of Adaptive and Functional Skills - WIDEA-FS) were assessed. Cox ...
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#1Marie-Coralie Cornet (UCSF: University of California, San Francisco)H-Index: 6
#2Valeria Morabito (Catholic University of Leuven)H-Index: 1
Last. Maria Roberta Cilio (Catholic University of Leuven)H-Index: 37
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OBJECTIVE Although most seizures in neonates are due to acute brain injury, some represent the first sign of neonatal onset genetic epilepsies. Delay in recognition and lack of expert assessment of neonates with epilepsy may result in worse developmental outcomes. As in older children and adults, seizure semiology in neonates is an essential determinant in diagnosis. We aimed to establish whether seizure type at presentation in neonates can suggest a genetic etiology. METHODS We retrospectively ...
1 CitationsSource
#1Courtney J. Wusthoff (Stanford University)H-Index: 28
#2Vandana Sundaram (Stanford University)H-Index: 25
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
view all 15 authors...
OBJECTIVE To determine whether screening continuous EEG monitoring (cEEG) is associated with greater odds of treatment success for neonatal seizures. METHODS We included term neonates with acute symptomatic seizures enrolled in the Neonatal Seizure Registry (NSR), a prospective, multicenter cohort of neonates with seizures. We compared two cEEG approaches: (1) Screening cEEG, initiated for indications of encephalopathy or paralysis without suspected clinical seizures, and (2) Confirmatory cEEG, ...
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#1Bo Lyun Lee (Inje University)
#2Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal encephalopathy with a global incidence of approximately 1 to 8 per 1,000 live births. Neonatal encephalopathy can cause neurodevelopmental and cognitive impairments in survivors of hypoxic-ischemic insults with and without functional motor deficits. Normal neurodevelopmental outcomes in early childhood does not preclude cognitive and behavioral difficulties in late childhood and adolescence because cognitive functions are...
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#1Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
#2Janet S. Soul (Boston Children's Hospital)H-Index: 37
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
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Importance Antiseizure medication (ASM) treatment duration for acute symptomatic neonatal seizures is variable. A randomized clinical trial of phenobarbital compared with placebo after resolution of acute symptomatic seizures closed early owing to low enrollment. Objective To assess whether ASM discontinuation after resolution of acute symptomatic neonatal seizures and before hospital discharge is associated with functional neurodevelopment or risk of epilepsy at age 24 months. Design, Setting, ...
1 CitationsSource
#1Adam L. Numis (UCSF: University of California, San Francisco)H-Index: 13
#2Gilberto da Gente (UCSF: University of California, San Francisco)H-Index: 3
Last. Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
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BACKGROUND The contribution of pathogenic gene variants with development of epilepsy after acute symptomatic neonatal seizures is not known. METHODS Case-control study of 20 trios in children with a history of acute symptomatic neonatal seizures: 10 with and 10 without post-neonatal epilepsy. We performed whole-exome sequencing (WES) and identified pathogenic de novo, transmitted, and non-transmitted variants from established and candidate epilepsy association genes and correlated prevalence of ...
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Neonatal encephalopathy is a clinical syndrome of neurologic dysfunction that encompasses a broad spectrum of symptoms and severity, from mild irritability and feeding difficulties to coma and seizures. It is vital for providers to understand that the term "neonatal encephalopathy" is simply a description of the neonate's neurologic status that is agnostic to the underlying etiology. Unfortunately, hypoxic-ischemic encephalopathy (HIE) has become common vernacular to describe any neonate with en...
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#1Colleen Peyton (NU: Northwestern University)H-Index: 9
#2Michael E. Msall (U of C: University of Chicago)H-Index: 55
Last. Hannah C. GlassH-Index: 37
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AIM To determine the concurrent validity of the Warner Initial Developmental Evaluation of Adaptive and Functional Skills (WIDEA-FS), a criterion-specified questionnaire that assesses a child's adaptive skills in everyday contexts, and the Bayley Infant and Toddler Scales of Development, Third Edition (Bayley-III). METHOD In a prospective cohort study, 431 WIDEA-FS and Bayley-III assessments were completed among 341 children, aged 10 to 36 months corrected age (158 females, 183 males; median [in...
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#1Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
#2Yi Li (UCSF: University of California, San Francisco)H-Index: 94
Last. Elizabeth E. Rogers (UCSF: University of California, San Francisco)H-Index: 25
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Abstract Aim Cerebral palsy (CP) is the most common motor disability of childhood. Its early identification is an important priority for parents and is critical for access to early intervention resources, which may optimize function. Methods Prospective cohort of term neonates at high risk for CP was assessed by neonatal MRI to determine myelination of the posterior limb of the internal capsule (PLIC), General Movements Assessment (GMA) to assess typical fidgety movements at three months of age,...
1 CitationsSource
#1Joshua L. Bonkowsky (UofU: University of Utah)H-Index: 28
#2Gabrielle deVeber (U of T: University of Toronto)H-Index: 85
Last. Janet S. SoulH-Index: 37
view all 23 authors...
Abstract Background 2020 marked a fundamental shift in the pediatric neurology field. An impressive positive trajectory of advances in patient care and research faced sudden global disruptions by the COVID-19 pandemic and by an international movement protesting racial, socioeconomic, and health disparities. The disruptions revealed obstacles and fragility within the pediatric neurology research mission. However, renewed commitment offers unique opportunites for the pediatric neurology research c...
3 CitationsSource