Shihui Chen
The Chinese University of Hong Kong
Proto-oncogene tyrosine-protein kinase SrcAdipogenesisEndocrinologyBiomedical engineeringSurgeryChemistryMaterials scienceMesenchymal stem cellIn vivoBone mineralUlnaBone marrowPLGAAngiogenesisBone regenerationBone resorptionMedicineBone healingScaffoldPharmacology
22Publications
11H-index
316Citations
Publications 22
Newest
#1Ya-Ping Luo (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Ying-Ying Li (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Shihui Chen (CUHK: The Chinese University of Hong Kong)H-Index: 11
view all 7 authors...
Summary Background/Objective Steroid-associated osteonecrosis (SAON) mostly occurs in large joints such as hip that finally results in joint collapse and replacement. An effective strategy for preventing SAON is inhibition of bone resorption and lipid formation, whereas promoting bone formation at osteonecrotic-sensitive skeletal sites. The objective of this study was to investigate whether gastrin administration could effectively prevent SAON in vivo and had a significant effect on osteogenesis...
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#1Guang-Sen Shi (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Ying-Ying Li (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Shihui Chen (CUHK: The Chinese University of Hong Kong)H-Index: 11
view all 11 authors...
Abstract Background/objectives For treatment of large bone defects challenging in orthopaedic clinics, bone graft substitutes are commonly used for the majority of surgeons. It would be proposed in the current study that our bioactive scaffolds could additionally serve as a local delivery system for therapeutic small molecule agents capable of providing support to enhance biological bone repair. Methods In this study, composite scaffolds made of poly (lactic-co-glycolic acid) (PLGA) and tricalci...
1 CitationsSource
#1Wenxue Tong (CUHK: The Chinese University of Hong Kong)H-Index: 8
#2Yelin Zeng (CUHK: The Chinese University of Hong Kong)H-Index: 1
Last. Kingston King-Lun MakH-Index: 4
view all 12 authors...
Objectives Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional relationship in OA progression in chondrocyte lineage. Methods The role of Wnt16 during skeletal development was examined by Col2a1-Wnt16 transgenic mice and Wnt16 fl/fl ;Col2a1-Cre...
14 CitationsSource
#1Nianye Zheng (CUHK: The Chinese University of Hong Kong)H-Index: 4
#2Xiaodong Liu (CUHK: The Chinese University of Hong Kong)H-Index: 15
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 11 authors...
Abstract BACKGROUND CONTEXT Cervical radicular pain resulting from mechanical compression of a spinal nerve secondary to spinal degenerative alternations negatively impacts patients’ quality of life. Jingshu Keli (JSKL), a traditional Chinese medicine formula with multiple active compounds, has been prescribed for pain management in patients with cervical radiculopathy for decades. Two major components of JSKL, ferulic acid and cinnamaldehyde, were identified to have anti-inflammation effect via...
5 CitationsSource
#1Shihui Chen (CUHK: The Chinese University of Hong Kong)H-Index: 11
#2Lizhen Zheng (CUHK: The Chinese University of Hong Kong)H-Index: 17
Last. Ling Qin (CAS: Chinese Academy of Sciences)H-Index: 58
view all 13 authors...
Abstract One of the effective strategies for prevention of steroid-associated osteonecrosis (SAON) is to inhibit bone resorption and fat formation and promote bone formation at osteonecrotic sensitive skeletal sites. We identified a novel phytomolecule that showed positive effects on osteogenesis, anti-bone resorption and anti-adipogenesis in vitro and also developed a bone-targeting delivery system (BTDS) for in vivo experimental study. The study investigated if our innovative synthesized BTDS ...
13 CitationsSource
#1Wai-Ching Liu (CUHK: The Chinese University of Hong Kong)H-Index: 9
#2Shihui Chen (CUHK: The Chinese University of Hong Kong)H-Index: 11
Last. Ling Qin (CAS: Chinese Academy of Sciences)H-Index: 58
view all 4 authors...
Vascularization is an essential process in bone formation, remodeling and regeneration during both bone development and fracture repair. Vascularization remains a big challenge directly leading to the final success of newly regenerated bone. In this review, the advantages and disadvantages of different angiogenesis assays and bone defect models are described in details for investigating revascularization of materials of interest. Unlike conventional angiogenesis study with growth factors or phar...
21 CitationsSource
#1Shihui Chen (HMU: Harbin Medical University)H-Index: 11
#2Poying Lau (CUHK: The Chinese University of Hong Kong)H-Index: 2
Last. Shekhar M. Kumta (CUHK: The Chinese University of Hong Kong)H-Index: 28
view all 8 authors...
A functional biomaterial with a therapeutic effect is desirable as an adjuvant therapy to enhance bone formation and prevent local recurrence of bone tumours, especially when the resection margins are not identifiable. In this study, novel composite materials were developed with dual properties of osteopromotion and bone resorption to mimic the tumour inhibition effect, including water-soluble phosphorylated chitosan (P-chitosan) for increasing osteoblasts activity and disodium (1 4)-2-deoxy-2-s...
5 CitationsSource
#1Lizhen Zheng (CUHK: The Chinese University of Hong Kong)H-Index: 17
#2Xinluan Wang (CAS: Chinese Academy of Sciences)H-Index: 25
Last. Ling Qin (CAS: Chinese Academy of Sciences)H-Index: 58
view all 6 authors...
Abstract In an established steroid-associated osteonecrosis (SAON) rabbit model we found recently that blockage Src by siRNA could improve reconstructive repair of osteonecrosis via enhancing osteogenesis and inhibiting bone resorption. The current study investigated if blocking Src was able to prevent steroid-associated osteoporosis (SAOP) in the same SAON animal model. Rabbits were treated with pulsed lipopolysaccharide (LPS) and corticosteroid methylprednisolone (MPS). At 2, 4, and 6 weeks af...
6 CitationsSource
#1Shihui Chen (CUHK: The Chinese University of Hong Kong)H-Index: 11
#2Xinluan Wang (CAS: Chinese Academy of Sciences)H-Index: 25
Last. Ling Qin (CAS: Chinese Academy of Sciences)H-Index: 58
view all 9 authors...
Summary Background/Objective Epimedii Folium is the most important osteogenic herb formulated for the traditional Chinese Medicine Xian Ling Gu Bao (XLGB) capsule. The present study compared XLGB capsules containing two different Epimedium species, i.e., either Epimedium pubescens (XEP) or Epimedium koreanum (XEK), with the focus being on the chemical constituents and antiosteoporotic efficacy. Methods Ultra performance liquid chromatography was used to demonstrate the different chemical constit...
10 CitationsSource
#1Lizhen Zheng (CUHK: The Chinese University of Hong Kong)H-Index: 17
#2Huijuan CaoH-Index: 8
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 15 authors...
Vascular hyperpermeability and highly upregulated bone resorption in the destructive repair progress of steroid-associated osteonecrosis (SAON) are associated with a high expression of VEGF and high Src activity (Src is encoded by the cellular sarcoma [c-src] gene). This study was designed to prove our hypothesis that blocking the VEGF-Src signaling pathway by specific Src siRNA is able to prevent destructive repair in a SAON rabbit model. Destructive repair in SAON was induced in rabbits. At 2,...
17 CitationsSource
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