KH Wong
The Royal Marsden NHS Foundation Trust
CancerInternal medicineRadiologyDistressSurgeryOncologyPsychosocialIntensive care medicineStage (cooking)Cohort studyInduction chemotherapyHead and neck squamous-cell carcinomaImmunotherapyEsophageal cancerQuality of life (healthcare)Nuclear medicinePrognostic factorHead and neckRadiation therapyMedicineGerontologyGastroenterology
31Publications
4H-index
134Citations
Publications 29
Newest
BACKGROUND Previous studies have suggested that inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH) and fibrinogen) are prognostic biomarkers in patients with a variety of solid cancers, including those treated with immune checkpoint inhibitors (ICIs). We aimed to develop a model that predicts response and survival in patients with relapsed and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy. METHODS Analysis of 100...
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#1Lucinda Gunn (The Royal Marsden NHS Foundation Trust)H-Index: 1
#1Gunn Lucinda (The Royal Marsden NHS Foundation Trust)
Last. Nutting Chris (ICR: Institute of Cancer Research)
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Abstract Background An intact sense of taste provides pleasure, supports sustenance and alerts the body to toxins. Head and neck cancer (HNC) patients who receive radiotherapy (RT) are high-risk for developing radiation-induced taste dysfunction. Advances in RT offer opportunities for taste-preserving strategies by reducing dose to the gustatory organs-at-risk. Methods PubMed, Medline and EMBASE were searched for publications reporting on taste, RT and HNC. Randomised trials, cohort studies and ...
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#2Omar Breik (Queen Elizabeth Hospital Birmingham)H-Index: 2
Last. Anthony KongH-Index: 20
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Nivolumab is an anti-PD-1 monoclonal antibody currently used as immunotherapy for patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) with evidence of disease progression after platinum-based chemotherapy. This study evaluates real-world safety and treatment outcomes of non-trial nivolumab use. A retrospective multicenter cohort study of patients with recurrent/metastatic HNSCC treated with nivolumab between January 2017 and March 2020 was performed. Overall, 123 pat...
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#1Kevin J. Harrington (ICR: Institute of Cancer Research)H-Index: 98
#2Shreerang A. Bhide (The Royal Marsden NHS Foundation Trust)H-Index: 22
Last. KH Wong (The Royal Marsden NHS Foundation Trust)H-Index: 4
view all 15 authors...
2 CitationsSource
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#1Jamie Dean (The Royal Marsden NHS Foundation Trust)H-Index: 9
#2Liam Welsh (The Royal Marsden NHS Foundation Trust)H-Index: 14
Last. Sarah L. Gulliford (The Royal Marsden NHS Foundation Trust)H-Index: 23
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Abstract Aims A normal tissue complication probability (NTCP) model of severe acute mucositis would be highly useful to guide clinical decision making and inform radiotherapy planning. We aimed to improve upon our previous model by using a novel oral mucosal surface organ at risk (OAR) in place of an oral cavity OAR. Materials and methods Predictive models of severe acute mucositis were generated using radiotherapy dose to the oral cavity OAR or mucosal surface OAR and clinical data. Penalised l...
12 CitationsSource
#1F. Guerreiro (University of Lisbon)H-Index: 1
#2Ninon Burgos (UCL: University College London)H-Index: 15
Last. Antje-Christin Knopf (ICR: Institute of Cancer Research)H-Index: 11
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BACKGROUND AND PURPOSE: Computed tomography (CT) imaging is the current gold standard for radiotherapy treatment planning (RTP). The establishment of a magnetic resonance imaging (MRI) only RTP workflow requires the generation of a synthetic CT (sCT) for dose calculation. This study evaluates the feasibility of using a multi-atlas sCT synthesis approach (sCTa) for head and neck and prostate patients. MATERIAL AND METHODS: The multi-atlas method was based on pairs of non-rigidly aligned MR and CT...
35 CitationsSource
#1KH Wong (ICR: Institute of Cancer Research)H-Index: 4
#1Kee Howe Wong (ICR: Institute of Cancer Research)H-Index: 1
Last. Kate Newbold (The Royal Marsden NHS Foundation Trust)H-Index: 32
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The objective of this study was to assess the predictive value of early assessment (after 1 cycle of induction chemotherapy [IC]) with F-18-FDG PET/CT and diffusion-weighted (DW) MRI for subsequent response to radical chemoradiotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC). Methods: Twenty patients with stage III-IVa HNSCC prospectively underwent F-18-FDG PET/CT and DW MRI before and 2 wk after each cycle of IC (first cycle, IC1; second cycle, IC2). Response was asses...
29 CitationsSource
#1Shreerang A. Bhide (The Royal Marsden NHS Foundation Trust)H-Index: 22
#1S.A. Bhide (The Royal Marsden NHS Foundation Trust)H-Index: 14
Last. K.J. Harrington (ICR: Institute of Cancer Research)H-Index: 7
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#1Shreerang A. Bhide (ICR: Institute of Cancer Research)H-Index: 22
#1S.A. Bhide (ICR: Institute of Cancer Research)H-Index: 14
Last. Kevin J. Harrington (ICR: Institute of Cancer Research)H-Index: 98
view all 8 authors...
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma
8 CitationsSource