Horacio Cardenas
Northwestern University
CancerInternal medicineEndocrinologyMolecular biologyChemistryFollicular phaseDNA methylationEstrous cycleOvulationBlastocystOvarian cancerStem cellEpigeneticsCancer researchTestosteroneCancer stem cellAndrogen receptorMedicineBiologyCancer cell
71Publications
18H-index
1,138Citations
Publications 65
Newest
#1Jing Li (NU: Northwestern University)H-Index: 12
#1Junjie Li (NU: Northwestern University)
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Increased aerobic glycolysis is widely considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during development of therapeutic resistance is under-studied. Here, through high-throughput stimulated Raman scattering imaging and single cell analysis, we found that cisplatin-resistant cells exhibit increased uptake of exogenous fatty acids, accompanied with decreased glucose uptake and de novo lipogenesis, indicating a reprogramming from glucose and glycolysis dependent to fatt...
Source
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 14 authors...
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Add...
5 CitationsSource
#1Horacio Cardenas (NU: Northwestern University)H-Index: 18
#2Fang Fang (IU: Indiana University)H-Index: 24
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 11 authors...
High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated...
Source
#1Hao Huang (NU: Northwestern University)H-Index: 25
#1Hao Huang (NU: Northwestern University)H-Index: 31
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 10 authors...
Introduction: N6-Methyladenosine (m6A) is the most abundant internal modification in mammalian messenger RNAs (mRNAs). Although previous studies have showed that RNA methylation is reversible and plays important roles in various cellular processes, such as metabolism, stem cell development, and self-renewal, its functions in cancer remain elusive. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase and was described as an oncogenic factor in leukemia and brain tumors. We hyp...
Source
#1Hao Huang (NU: Northwestern University)H-Index: 31
#1Hao Huang (NU: Northwestern University)H-Index: 25
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 11 authors...
N6-Methyladenosine (m6A) is the most abundant modification of mammalian messenger RNAs (mRNA). RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase with oncogenic properties in leukemia. Here we show that FTO expression is suppressed in ovarian tumors and cancer stem cells (CSC). FTO inhibited the self-renewal of ovarian CSC and suppressed tumorigenesis in vivo, both of which required FTO demethylas...
13 CitationsSource
#1Salvatore CondelloH-Index: 1
#1Salvatore CondelloH-Index: 18
Last. Daniela MateiH-Index: 59
view all 7 authors...
Source
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 13 authors...
Defining traits of platinum tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum tolerant cells and tumors were identified by using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were found to be enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to pare...
Source
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#2Guangyuan Zhao (NU: Northwestern University)H-Index: 7
Last. Yuying Tan (BU: Boston University)H-Index: 6
view all 13 authors...
Defining traits of platinum tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum tolerant cells and tumors were identified by using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were found to be enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to pare...
3 CitationsSource
#1Daniela Matei (NU: Northwestern University)H-Index: 59
#2Alok Pant (NU: Northwestern University)H-Index: 3
Last. Bin Zhang (NU: Northwestern University)H-Index: 41
view all 14 authors...
6025Background: Platinum resistant ovarian cancer (PROC) remains a disease of high need. Immune checkpoint inhibitors (ICI) have modest activity. We hypothesized that priming with a hypomethylating...
1 CitationsSource
#1Horacio Cardenas (NU: Northwestern University)H-Index: 18
#2Guanglong Jiang (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 14
Last. Daniela Matei (NU: Northwestern University)H-Index: 2
view all 10 authors...
Loss-of-function mutations of the breast cancer type 1 susceptibility protein (BRCA1) are associated with breast (BC) and ovarian cancer (OC). To identify gene signatures regulated by epigenetic mechanisms in OC cells carrying BRCA1 mutations, we assessed cellular responses to epigenome modifiers and performed genome-wide RNA- and chromatin immunoprecipitation-sequencing in isogenic OC cells UWB1.289 (carrying a BRCA1 mutation, BRCA1-null) and UWB1.289 transduced with wild-type BRCA1 (BRCA1+). I...
2 CitationsSource