Markus W. Büchler
University Hospital Heidelberg
CancerInternal medicineRadiologyEndocrinologySurgeryPathologyOncologyResectionRandomized controlled trialPancreatitisAcute pancreatitisPancreatic diseasePancreasAbdominal surgeryPancreatic cancerCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 1677
#1Lukas F. Liesenfeld (University Hospital Heidelberg)H-Index: 1
#2Thomas Schmidt (University Hospital Heidelberg)H-Index: 31
Last. Anja Schaible (University Hospital Heidelberg)H-Index: 8
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Abstract null null Background null Anastomotic leakage (AL) is a common and severe complication after upper gastrointestinal (UGI) surgery. Although evidence is scarce, endoscopic deployed self-expanding metal stents (SEMS) are well-established for the management of AL in UGI surgery. The present study aimed to evaluate the feasibility, effectiveness, and safety of SEMS in terms of success, mortality, and morbidity in patients with AL after UGI cancer surgery. null null null Materials and Method...
#1Johannes Klose (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 10
#2Annelene Schmitt (Heidelberg University)
Last. Ignazio Tarantino (Heidelberg University)H-Index: 23
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Abstract Introduction Distant recurrence, especially liver metastases, occurs in one-third of rectal cancer patients initially treated with curative therapy and is still an unsolved problem. The identification of patients at risk is crucial for enabling individualized treatment. Material and methods All patients undergoing curative resection for histologically confirmed rectal cancer after neoadjuvant radiochemotherapy between January 2001 and December 2015 were included. Sections were stained f...
#1Anna-Katharina König (University Hospital Heidelberg)H-Index: 2
#2Hélène Gros (University Hospital Heidelberg)
Last. Oliver Strobel (University Hospital Heidelberg)H-Index: 50
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BACKGROUND With changes in T and N categories the 8th edition of the AJCC/UICC TNM staging system for pancreatic cancer resulted in improved prognostic staging, but inconsistencies were observed with specific stage groups. Tumour grading remains disregarded in prognostic staging. We aimed to validate the current staging system and to investigate the possibility of further optimization by integration of grading. METHODS 1946 patients undergoing upfront surgical resection for pancreatic adenocarci...
#1Lukas F. Liesenfeld (University Hospital Heidelberg)H-Index: 1
#2Benedikt Wagner (University Hospital Heidelberg)H-Index: 1
Last. Martin Schneider (University Hospital Heidelberg)H-Index: 23
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BACKGROUND Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) is the treatment of choice for selected patients with peritoneal malignancies. HIPEC is accompanied by moderate-to-high patient morbidity, including acute kidney injury. The significance of nephrotoxic agents such as cisplatin versus hyperthermia in HIPEC-induced nephrotoxicity has not been defined yet. PATIENTS AND METHODS A total of 153 patients treated with HIPEC were divided into groups wit...
#1Martin Schneider (University Hospital Heidelberg)H-Index: 23
#2Markus W. Büchler (University Hospital Heidelberg)H-Index: 173
BACKGROUND Endoscopically unresectable adenomas and carcinomas of the greater duodenal papilla and ampulla of the bile duct necessitate surgical resection. The surgical techniques need to be adapted to local tumor expansion and patterns of infiltrative growth. OBJECTIVE Based on the current scientific data and developments this article provides an overview of indications for surgical resection, surgical strategies and dissection techniques for ampullary tumors. MATERIAL AND METHODS A review of t...
#1Mohammad H. Fard-Aghaie (Semmelweis University)H-Index: 4
#2Georgios Makridis (Semmelweis University)H-Index: 3
Last. Juergen KlempnauerH-Index: 36
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Abstract null null Background null Caroli Disease (CD) and Caroli Syndrome (CS) are rare disorders presenting with dilation of the intrahepatic bile ducts. CD/CS are associated with cholangiocarcinoma (CCA). However, the true incidence of CCA is still unclear, although it may serve as an indication for surgery. In this paper, we analyzed (I) the incidence of CCA in German centers, (II) reviewed our single center population together with its clinical presentation and (III) performed a thorough li...
#1Rosa Klotz (Heidelberg University)H-Index: 3
#2Thilo Hackert (Heidelberg University)H-Index: 57
Last. Beat P. Müller-Stich (Heidelberg University)H-Index: 33
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Abstract null null Background null Surgical resection is the mainstay of potential cure for patients with pancreatic cancer, however, local recurrence is frequent. Previously, we have described an extended resection technique for pancreatoduodenectomy aiming at a radical resection of the nerve and lymphatic tissue between celiac artery, superior mesenteric artery and mesenteric-portal axis (TRIANGLE operation). Until now, data on postoperative outcome have not been reported, yet. null null null ...
#1Pascal Probst (Heidelberg University)H-Index: 22
#2Felix J Hüttner (Heidelberg University)H-Index: 16
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
#1Christine Tjaden (University Hospital Heidelberg)H-Index: 12
#2Ulf HinzH-Index: 64
Last. Christoph BerchtoldH-Index: 5
view all 15 authors...
Objective null Evaluation of the outcome after resection for distal bile duct cancer (DBC) with focus on the impact of microscopic histopathological resection status R0 (>1 mm) vs R1 (≤1 mm) vs R1 (direct). null Summary background data null DBC is a rare disease for which oncologic resection offers the only chance of cure. null Methods null Prospectively collected data of consecutive patients undergoing pancreaticoduodenectomy for DBC were analyzed. Histopathological resection status was classif...
#1Susanne Roth (University Hospital Heidelberg)H-Index: 11
#1Susanne Roth (University Hospital Heidelberg)H-Index: 1
Last. Thilo Hackert (University Hospital Heidelberg)H-Index: 57
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OBJECTIVE To propose a noninvasive diagnostic approach, which allows reliable distinction between low- and high-risk pancreatic intraductal papillary mucinous neoplasms (IPMNs). BACKGROUND IPMNs are identifiable precursor lesions of pancreatic cancer, of which surgical resection is warranted prior to the development of invasive carcinoma, but low-grade IPMNs should not be unnecessarily resected. However, diagnostic tools that preoperatively enable accurate risk stratification of IPMNs are missin...
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