Luis J. del Valle
Polytechnic University of Catalonia
BiophysicsConductive polymerElectrospinningNanoparticleCopolymerPEDOT:PSSNanotechnologyOrganic chemistryChemistryPolymer chemistryMaterials scienceCrystallizationBiocompatibilityPolythiopheneDrug deliveryChemical engineeringPolymerizationCrystallinityPolymerMedicineBiologyNanofiber
193Publications
27H-index
2,501Citations
Publications 186
Newest
#1Anna Puiggalí-Jou (UPC: Polytechnic University of Catalonia)H-Index: 7
#2Luis J. del Valle (UPC: Polytechnic University of Catalonia)H-Index: 27
Last. Carlos Alemán (UPC: Polytechnic University of Catalonia)H-Index: 56
view all 4 authors...
The properties as biointerfaces of electroactive conducting polymer-peptide biocomposites formed by poly(3,4-ethylenedioxythiophene) (PEDOT) and CREKA or CR(NMe)EKA peptide sequences (where Glu has been replaced by N-methyl-Glu in the latter) have been compared. CREKA is a linear pentapeptide that recognizes clotted plasma proteins and selectively homes to tumors, while CR(NMe)EKA is an engineer to improve such properties by altering peptide-fibrin interactions. Differences between PEDOT-CREKA a...
6 CitationsSource
#1Enric Mayans (UPC: Polytechnic University of Catalonia)H-Index: 6
#2Gema Ballano (University of Zaragoza)H-Index: 7
Last. Carlos Alemán (UPC: Polytechnic University of Catalonia)H-Index: 56
view all 10 authors...
Homopeptides with 2, 3 and 4 phenylalanine (Phe) residues and capped with fluorenylmethoxycarbonyl and fluorenylmethyl esters at the N-terminus and C-terminus, respectively, have been synthesized to examine their self-assembly capabilities. Depending on the conditions, the di- and triphenylalanine derivatives self-organize into a wide variety of stable polymorphic structures, which have been characterized: stacked braids, doughnut-like shapes, bundled arrays of nanotubes, corkscrew-like shapes a...
15 CitationsSource
#1Francesc Estrany (UPC: Polytechnic University of Catalonia)H-Index: 23
#2Aureli Calvet (UPC: Polytechnic University of Catalonia)H-Index: 2
Last. Carlos Alemán (UPC: Polytechnic University of Catalonia)H-Index: 56
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After exhibiting the important limitations of the template-assisted approach when electropolymerization on simple stainless steel electrodes and electrospinning of insulating polymeric templates are combined, hollow poly(3,4-ethylenedioxythiophene) (PEDOT) nano- and microtubes have been successfully prepared using an alternative approach. In this procedure, which is based on a two-step electropolymerization process, electrospun fibers are collected onto a relatively flat PEDOT film that plays a ...
6 CitationsSource
#1Lucie Ecker (UPCH: Cayetano Heredia University)H-Index: 12
#2Joaquín Ruiz (University of Barcelona)H-Index: 19
Last. Theresa J. Ochoa (University of Texas at Austin)H-Index: 31
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Objectives. To determine the prevalence of purchase of antibiotics without prescription and antibiotic recommendation for its use in children <5 years of age in private pharmacies in peri-urban areas of Lima. Materials and methods. An anonymous population survey was conducted among adults who bought an antibiotic for a child <5 years of age from a private pharmacy. Fictitious cases were applied in a subgroup of pharmacies to evaluate antibiotic recommendation practices. Results. The prevalence o...
4 CitationsSource
#1Oscar Bertran (UPC: Polytechnic University of Catalonia)H-Index: 15
#2Guillermo Revilla-López (UPC: Polytechnic University of Catalonia)H-Index: 10
Last. Carlos Alemán (UPC: Polytechnic University of Catalonia)H-Index: 56
view all 7 authors...
In spite of the clinical importance of hydroxyapatite (HAp), the mechanism that controls its dissolution in acidic environments remains unclear. Knowledge of such a process is highly desirable to provide better understanding of different pathologies, as for example osteoporosis, and of the HAp potential as vehicle for gene delivery to replace damaged DNA. In this work, the mechanism of dissolution in acid conditions of HAp nanoparticles encapsulating double-stranded DNA has been investigated at ...
7 CitationsSource
#1Lourdes FrancoH-Index: 25
#2Luis J. del ValleH-Index: 27
Last. Jordi PuiggalíH-Index: 39
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Increasing interest for the application of polypeptide-based smart systems in the biomedical field has developed due to the advantages given by the peptidic sequence. This is due to characteristics of these systems, which include: biocompatibility, potential control of degradation, capability to provide a rich repertoire of biologically specific interactions, feasibility to self-assemble, possibility to combine different functionalities, and capability to give an environmentally responsive behav...
4 CitationsSource
#1Luis J. del ValleH-Index: 27
#2Lourdes FrancoH-Index: 25
Last. Jordi Puiggalí (UPC: Polytechnic University of Catalonia)H-Index: 1
view all 4 authors...
Development of materials with an antimicrobial activity is fundamental for different sectors, including medicine and health care, water and air treatment, and food packaging. Electrospinning is a versatile and economic technique that allows the incorporation of different natural, industrial, and clinical agents into a wide variety of polymers and blends in the form of micro/nanofibers. Furthermore, the technique is versatile since different constructs (e.g. those derived from single electrospinn...
15 CitationsSource
#1Elena Llorens (UPC: Polytechnic University of Catalonia)H-Index: 8
#2Luis J. del Valle (UPC: Polytechnic University of Catalonia)H-Index: 27
Last. Jordi Puiggalí (UPC: Polytechnic University of Catalonia)H-Index: 39
view all 3 authors...
Multifunctional electrospun scaffolds were prepared from two polylactide (PLA) grades having slightly different d-lactide content (4.2 wt % and 2.0 wt %). Triclosan (TCS), ketoprofen (KTP), and p-coumaric acid (CUM) were selected as bactericide, anti-inflammatory, and antioxidant agents, respectively. Single, binary, and ternary drug-loaded microfibers having a unimodal diameter distribution could be prepared using a common chloroform:acetone:dimethylsulfoxide mixture and similar operational par...
18 CitationsSource
#1Anna Puiggalí-Jou (UPC: Polytechnic University of Catalonia)H-Index: 7
#2Judith Medina (UPC: Polytechnic University of Catalonia)H-Index: 2
Last. Carlos Alemán (UPC: Polytechnic University of Catalonia)H-Index: 56
view all 4 authors...
Nanoperforated poly(lactic acid) (PLA) free-standing nanomembranes (FsNMs) have been prepared using a two-step process: (1) spin-coating a mixture of immiscible polymers to provoke phase segregation and formation of appropriated nanofeatures (i.e. phase separation domains with dimensions similar to the entire film thickness); and (2) selective solvent etching to transform such nanofeatures into nanoperforations. For this purpose, PLA has been mixed with polyethylene glycol (PEG) and poly(vinyl a...
14 CitationsSource
#1Sara K. Murase (UPC: Polytechnic University of Catalonia)H-Index: 6
#2Mireia Aymat (UPC: Polytechnic University of Catalonia)H-Index: 1
Last. Jordi Puiggalí (UPC: Polytechnic University of Catalonia)H-Index: 39
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Electrospraying of poly(butylene succinate) and its mixture with different indole derivatives was successfully performed using chloroform as solvent and relatively low flow rates and concentrations. Morphology of particles (size, diameter distribution and surface texture) and encapsulation efficiency were dependent on the loaded drug and specifically on the type of substituent (methyl or phenyl) and its position in the indole core. In general, particles showed a raisin-like morphology caused by ...
13 CitationsSource