Masayo Takahashi
Kyoto University
Induced pluripotent stem cellOphthalmologyNeural stem cellPathologyEmbryonic stem cellCellular differentiationMolecular biologyNeuroscienceAdult stem cellMacular degenerationRetinaRetinal pigment epitheliumRetinalRetinal degenerationRetinitis pigmentosaStem cellTransplantationMedicineBiologyCell biology
266Publications
46H-index
11.6kCitations
Publications 240
Newest
#1Tadao MaedaH-Index: 36
#2Sunao SugitaH-Index: 40
Last. Masayo TakahashiH-Index: 46
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Age-related macular degeneration (AMD) is a highly prevalent irreversible impairment in the elderly population worldwide. Stem cell therapies have been considered potentially viable for treating AMD through the direct replacement of degenerated cells or secretion of trophic factors that facilitate the survival of existing cells. Among them, the safety of pluripotent stem cell-derived retinal pigment epithelial (RPE) cell transplantation against AMD, and some hereditary retinal degenerative disea...
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#1Suguru YamasakiH-Index: 5
#2Sunao SugitaH-Index: 40
Last. Michiko MandaiH-Index: 38
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Summary ESC- and iPSC-derived retinal transplantation is a promising therapeutic approach for disease with end-stage retinal degeneration, such as retinitis pigmentosa and age-related macular degeneration. We previously showed medium- to long-term survival, maturation, and light response of transplanted human ESC- and iPSC-retina in mouse, rat, and monkey models of end-stage retinal degeneration. Because the use of patient hiPSC-derived retina with a disease-causing gene mutation is not appropri...
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In an intraocular inflammatory state, microglia residing in the retina become active and migrate inside the retina. In this study, we investigated whether cyclooxygenase-1 (COX-1) expressed by retinal microglia/macrophage can be a biomarker for the diagnosis of retinal diseases. COX-1 was immunopositive in microglia/macrophage and neutrophils, while COX-2 was immunopositive in astrocytes and neurons in the inner layer of normal retina. The number of COX-1 positive cells per section of the retina...
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#1Masaaki IshidaH-Index: 2
#1Masaaki Ishida (Kyoto University)H-Index: 3
Last. Masayo TakahashiH-Index: 46
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Currently, retinal pigment epithelium (RPE) transplantation includes sheet and single-cell transplantation, the latter of which includes cell death and may be highly immunogenic, and there are some issues to be improved in single-cell transplantation. Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), the downstream kinase of Rho. We herein investigated the effect of Y-27632 in vitro on retinal pigment epithelium derived from induced pluripotent stem cells (iPS-RPE cells), and also...
1 CitationsSource
#1Take MatsuyamaH-Index: 6
#2Hung-Ya TuH-Index: 4
Last. Michiko MandaiH-Index: 38
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ES/iPS-retinal sheet transplantation, which supplies photoreceptors as well as other retinal cells, has been shown able to restore visual function in mice with end-stage retinal degeneration. Here, by introducing a novel type of genetically engineered ES/iPS-retinal sheet with reduced numbers of secondary retinal neurons but intact photoreceptor cell layer structure, we reinforced the evidence that ES/iPS-retinal sheet transplantation can establish synaptic connections with the host, restore lig...
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Abstract Retinal pigment epithelial (RPE) cells have several functions, including support of the neural retina and choroid in the eye and immunosuppression. Cultured human RPE cells directly suppress inflammatory immune cells. For instance, they directly suppress the activation of T cells in vitro. In contrast, transplanted allogeneic human RPE cells are rejected by bystander immune cells such as T cells in vivo. Recently, human embryonic stem cell-derived RPE cells have been used in several cli...
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1 CitationsSource
#1Genki N. KandaH-Index: 2
Last. Tohru NatsumeH-Index: 52
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#1Masahiro YamanariH-Index: 1
#1Masahiro YamanariH-Index: 27
Last. Yasuo KurimotoH-Index: 28
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2 CitationsSource
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