Hyo Sup Shim
Yonsei University
GeneAnaplastic lymphoma kinaseCancerInternal medicineRadiologyPathologyOncologyImmunohistochemistryHazard ratioROS1Lung cancerCarcinomaLungCrizotinibEpidermal growth factor receptorAdenocarcinomaKRASGene rearrangementCancer researchMedicineBiology
146Publications
28H-index
2,987Citations
Publications 149
Newest
#1Seoyoung Lee (Yonsei University)H-Index: 7
#2Hyo Sup Shim (Yonsei University)H-Index: 28
Last. Min Hee Hong (Yonsei University)H-Index: 17
view all 7 authors...
Patients with small-cell lung cancer (SCLC) have a dismal prognosis with limited overall survival (OS) despite a high response rate to chemotherapy. Recently, immune checkpoint inhibitors, combined with chemotherapy, as the first-line treatment for extensive-stage (ES)-SCLC have shown improvement in clinical outcomes. Real-world data from 68 Korean ES-SCLC patients, treated with atezolizumab, etoposide, and carboplatin at Yonsei Cancer Center between June 2019 and November 2020, were retrospecti...
Source
#1M. J. Yoon (Yonsei University)H-Index: 1
#2Seung-Hyun Lee (Yonsei University)H-Index: 21
Last. Seok Min Kang (Yonsei University)H-Index: 33
view all 4 authors...
Source
#1Jii Bum Lee (Yonsei University)H-Index: 2
#2Min Hee Hong (Yonsei University)H-Index: 17
Last. Hye Ryun Kim (Yonsei University)H-Index: 31
view all 8 authors...
Source
#1Moonsik Kim (KNU: Kyungpook National University)
#2Jinha Hwang (KU: Korea University)
Last. Hyo Sup Shim (Yonsei University)H-Index: 28
view all 9 authors...
Invasive mucinous adenocarcinoma (IMA) of the lung frequently presents with diffuse pneumonic-type features or multifocal lesions, which are regarded as a pattern of intrapulmonary metastases. However, the genomics of multifocal IMAs have not been well studied. We performed whole exome sequencing on samples taken from 2 to 5 regions in seven patients with synchronous multifocal IMAs of the lung (24 regions total). Early initiating driver events, such as KRAS, NKX2-1, TP53, or ARID1A mutations, a...
Source
#1Kyung Hwan Kim (Yonsei University)H-Index: 35
#2Han Sang Kim (Yonsei University)H-Index: 16
Last. Jee Suk Chang (Yonsei University)H-Index: 17
view all 9 authors...
Purpose Preclinical data indicate that response to radiotherapy (RT) depends on DNA damage repair. In this study, we investigated the role of mutations in genes related to DNA damage repair in treatment outcome after RT. Materials and Methods Patients with solid tumor who participated in next generation sequencing panel screening using biopsied tumor tissue between October 2013 and February 2019 were reviewed and 97 patients that received RT were included in this study. Best response to RT and t...
Source
#1Sun Min Lim (Yonsei University)H-Index: 24
#2San-Duk Yang (Yonsei University)H-Index: 1
Last. Byoung Chul Cho (Yonsei University)H-Index: 62
view all 5 authors...
Abstract Introduction MET amplification is a frequently observed mechanism of resistance to osimertinib, and co-inhibition strategy of MET and EGFR showed promising Results in recent clinical trials. However, acquired resistance mechanisms to combined EGFR and MET inhibition are poorly understood. In this study, we investigated mechanisms of acquired resistance to osimertinib and savolitinib by using pre-treatment and post-treatment tissue analysis. Methods Whole exome sequencing was performed i...
Source
#1Byung Jo Park (Yonsei University)
#2Hyo Sup Shim (Yonsei University)H-Index: 28
Last. Seong Yong Park (Yonsei University)H-Index: 17
view all 8 authors...
Most patients with oncogene-driven advanced non-small cell lung cancer (NSCLC) demonstrate recurrence because of the developing targeted therapy resistance. In this retrospective study, we assessed the efficacy of surgical local consolidative treatment by analyzing the operative outcomes and genetic data in 44 patients who underwent pulmonary resection for stage IIIB/C-IV NSCLC after targeted therapy. The initial mutations were in the EGFR (n = 32), ALK (n = 11), and ROS1 (n = 1) genes. The medi...
1 CitationsSource
#1Soo-Yeon Park (Yonsei University)H-Index: 11
#2Jung Yeon Hong (Yonsei University)H-Index: 11
Last. Ho-Geun Yoon (Yonsei University)H-Index: 35
view all 13 authors...
Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular gen...
1 CitationsSource
#1Sunhee Chang (Inje University)H-Index: 9
#2Hyo Sup Shim (Yonsei University)H-Index: 28
Last. Chang Hun Lee (PNU: Pusan National University)H-Index: 27
view all 10 authors...
Molecular biomarker testing is the standard of care for non-small cell lung cancer (NSCLC) patients. In 2017, the Korean Cardiopulmonary Pathology Study Group and the Korean Molecular Pathology Study Group co-published a molecular testing guideline which contained almost all known genetic changes that aid in treatment decisions or predict prognosis in patients with NSCLC. Since then there have been significant changes in targeted therapies as well as molecular testing including newly approved ta...
Source
#1Jii Bum Lee (Yonsei University)H-Index: 2
#2Min Hee Hong (Yonsei University)H-Index: 17
Last. Hye Ryun Kim (Yonsei University)H-Index: 31
view all 8 authors...
Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD-L1) in surgically resected squamous cell lung carcinoma (SQCC) and determined its prognostic significance. We collected archival surgical specimens and data of 259 patients with SQCC at Yonsei Cancer Center (1998-2020). Analysis of variance was used to analyze the correlations between PVR ...
Source