Xuezhu Zhang
University of California, Davis
Imaging phantomSilicon photomultiplierParametric statisticsOpticsPhysicsBiomedical engineeringIterative reconstructionArtificial intelligencePattern recognitionImage resolutionPositron emission tomographyScannerComputer visionComputer scienceImage qualityDetector
52Publications
13H-index
688Citations
Publications 52
Newest
#1Zhaoheng Xie (UC Davis: University of California, Davis)H-Index: 3
#2Tiantian Li (UC Davis: University of California, Davis)H-Index: 2
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
view all 6 authors...
PURPOSE The developments of PET/CT and PET/MR scanners provide opportunities for improving PET image quality by using anatomical information. In this paper, we propose a novel co-learning 3D convolutional neural network (CNN) to extract modality-specific features from PET/CT image pairs and integrate complementary features into an iterative reconstruction framework to improve PET image reconstruction. METHODS We used a pre-trained deep neural network to represent PET images. The network was trai...
Source
#1Tao FengH-Index: 9
#2Yizhang ZhaoH-Index: 1
Last. Terry L. Jones (UC Davis: University of California, Davis)H-Index: 30
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Parametric imaging has been shown to provide better quantitation physiologically compared with SUV imaging in PET. With the increased sensitivity from a recently developed total-body PET scanner, whole-body scans with higher temporal resolution become possible for dynamic analysis and parametric imaging. In this paper, we focus on deriving the parameter k1 using compartmental modeling, and on developing a method to acquire whole-body FDG-PET parametric images using only the first 90 seconds of t...
9 CitationsSource
#1Tiantian Li (UC Davis: University of California, Davis)H-Index: 2
#2Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 13
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
view all 7 authors...
60 Objectives: The uEXPLORER PET/CT system with ultra-high sensitivity and total-body coverage provides potential for more accurate quantification of a wide range of physiological parameters in vivo. Motion during dynamic PET data acquisition can cause image blurring and reduce quantitative accuracy. In this work, we apply our previously developed deep learning-based data-driven gating and motion compensation methods to improve the image quality of total-body parametric imaging. We demonstrate t...
54 null Introduction: null null Total-body dynamic PET can provide tracer kinetic assays of physiologically and biologically relevant information across the entire human body. Our previous work has demonstrated the capability of performing dynamic PET imaging with 100-ms temporal resolution on the uEXPLORER scanner. Sub-second dynamic PET imaging allows clear visualization of fast tracer dynamics after bolus injection with physiological (cardiac and respiratory) motion in real-time. In this work...
#1Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
#2Samuel Matej (UPenn: University of Pennsylvania)H-Index: 22
Last. Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 13
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Total-body PET image reconstruction follows a similar procedure to the image reconstruction process for standard whole-body PET scanners. One unique aspect of total-body imaging is simultaneous coverage of the entire human body, which makes it convenient to perform total-body dynamic PET scans. Therefore, four-dimensional dynamic PET reconstruction and parametric imaging are of great interest in total-body imaging. This article covers some basics of PET image reconstruction and then focuses on t...
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#1Tao Feng (BP)H-Index: 9
#2Gang YangH-Index: 1
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
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The conventional gating approach creates a dilemma for systems with large field-of-view (FOV) such as the uExplorer system. The motion effect is localized with variable motion amplitude across the whole FOV. A conventional gating approach would increase the noise for regions without motion, or with small motion amplitude. Existing local gating approach that allows optimized locally adaptive gating numbers requires a 4D reconstruction, which is time-consuming for generating of a 3D image. Image-d...
Source
#1Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 13
#2Zhaoheng Xie (UC Davis: University of California, Davis)H-Index: 3
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
view all 8 authors...
206 Introduction: The world’s first 2-meter long PET/CT scanner (uEXPLORER) has been developed to offer ultra-sensitive total-body molecular imaging for biomedical research and clinical applications. It provides opportunities for tracer kinetic analysis of the human body in terms of physiology, biochemistry and pharmacology. We have previously developed a linear parametric imaging method using the Patlak model. In this work, we investigate a nonlinear kinetic analysis method based on a two-tissu...
#1Li Cheng (UC Davis: University of California, Davis)H-Index: 1
#2Tianyu Ma (THU: Tsinghua University)H-Index: 13
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
view all 6 authors...
PURPOSE: We present a new method for joint reconstruction of activity and attenuation images using both emission and transmission data and demonstrate its advantage over the standard maximum likelihood activity and attenuation (MLAA) reconstruction using emission data alone. METHODS: We define a joint likelihood function including both time-of-flight (TOF) emission data and transmission data. The latter can be obtained from an external source or from Lu-176 background radiation. Activity and att...
2 CitationsSource
#1Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 13
#2Simon R. Cherry (UC Davis: University of California, Davis)H-Index: 93
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
view all 6 authors...
A 194-cm-long total-body positron emission tomography/computed tomography (PET/CT) scanner (uEXPLORER), has been constructed to offer a transformative platform for human radiotracer imaging in clinical research and healthcare. Its total-body coverage and exceptional sensitivity provide opportunities for innovative studies of physiology, biochemistry, and pharmacology. The objective of this study is to develop a method to perform ultrahigh (100 ms) temporal resolution dynamic PET imaging by combi...
36 CitationsSource
#1Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 13
#2Zhaoheng Xie (UC Davis: University of California, Davis)H-Index: 3
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 52
view all 21 authors...
: Rationale: The world's first 194-cm long total-body PET/CT scanner (uEXPLORER) has been built by the EXPLORER consortium to offer a transformative platform for human molecular imaging in clinical research and healthcare. Its total-body coverage and ultra-high sensitivity provide opportunities for more accurate tracer kinetic analysis in studies of physiology, biochemistry and pharmacology. The objective of this study is to demonstrate the capability of total-body parametric imaging and to quan...
56 CitationsSource