Ki-Sook Park
Kyung Hee University
Mitogen-activated protein kinaseEndocrinologyCadherinMolecular biologyStromal cellKinaseChemistryMesenchymal stem cellBone marrowWound healingAngiogenesisStem cellCancer researchMAPK/ERK pathwayCell growthSignal transductionEpithelial–mesenchymal transitionCell cultureBiologyCell biology
48Publications
18H-index
685Citations
Publications 47
Newest
#1Ki-Sook Park (Kyung Hee University)H-Index: 18
#1Ki-Sook Park (Seattle Children's Research Institute)
Last. Barry M. Gumbiner (Seattle Children's Research Institute)H-Index: 83
view all 3 authors...
Excessive vascular permeability occurs in inflammatory disease processes. Vascular endothelial cadherin (VE-cadherin) is an adhesion protein that controls vascular permeability. We identified monoclonal antibodies (mAbs) to human VE-cadherin that activate cell adhesion and inhibit the increased permeability of endothelial cell monolayers induced by thrombin receptor activator peptide-6 (TRAP-6). Two mAbs, 8A12c and 3A5a, reduce permeability while an inhibitory mAb, 2E11d, enhances permeability. ...
Source
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Sanghyuk Choi (Kyung Hee University)H-Index: 3
Last. Ki-Sook ParkH-Index: 18
view all 10 authors...
Cancer cachexia is a multifactorial systemic inflammation disease caused by complex interactions between the tumor and host tissues via soluble factors. However, whether cancer cachexia affects the bone marrow, in particular the hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), remains unclear. Here, we investigated the bone marrow and bone in a cancer cachexia animal model generated by transplanting Lewis lung carcinoma cells. The number of bone marrow mononuclear cells (BM-MNC...
Source
#1Sanghyuk ChoiH-Index: 3
#2Jinyeong YuH-Index: 5
Last. Ki-Sook ParkH-Index: 18
view all 4 authors...
Source
#1Donghyun Nam (Kyung Hee University)H-Index: 3
#2Aran Park (Kyung Hee University)H-Index: 1
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 7 authors...
Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or...
Source
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Donghyun Nam (Kyung Hee University)H-Index: 3
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 3 authors...
Abstract Diabetes induces cellular dysfunction in dermal fibroblasts, such as impairment in migration, which is a major cause of chronic wound. Here, we demonstrated that the migration of human dermal fibroblasts was impaired under a high glucose culture condition. Substance P (SP) rescued the impaired migration of the fibroblasts. The activity of Rac1, Rho-associated kinase (ROCK), and Src was required for SP-mediated rescue of fibroblast migration. SP activated Rac1 and Src, whereas, NSC23766,...
3 CitationsSource
#1Sanghyuk Choi (Kyung Hee University)H-Index: 3
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 9 authors...
Bone morphogenetic protein (BMP) signaling and Notch signaling play important roles in tumorigenesis in various organs and tissues, including the breast. BMP-4 enhanced epithelial mesenchymal transition (EMT) and stem cell properties in both mammary epithelial cell line and breast carcinoma cell line. BMP-4 increased the expression of EMT biomarkers, such as fibronectin, laminin, N-cadherin, and Slug. BMP-4 also activated Notch signaling in these cells and increased the sphere forming efficiency...
9 CitationsSource
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Hye Min Kim (Kyung Hee University)H-Index: 2
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 6 authors...
Abstract Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-β. However, the roles of i...
3 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Nunggum Jung (Kyung Hee University)H-Index: 4
Last. Ki-Sook ParkH-Index: 18
view all 7 authors...
Abstract Preservation of pancreatic β-cells is required for the development of therapies for type 1 and type 2 diabetes (T1D and T2D, respectively). Our previous study demonstrated that substance P (SP) preserves β-cell populations in mice with streptozotocin-induced T1D. Here, we demonstrated that chronic systemic treatment with SP restored the mass of β-cells both in nonobese diabetic (NOD) mice with T1D or db/db mice with T2D. SP delayed the onset of T1D in NOD mice via immune modulation. SP ...
3 CitationsSource
#1Hyeongwon ChoiH-Index: 5
#2Dong-Jin KimH-Index: 11
Last. Youngsook SonH-Index: 23
view all 10 authors...
: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by intense pruritus and eczematous lesion. In this study, topically applied substance P (SP) significantly alleviated AD-like clinical symptoms in 2, 4, 6-trinitrochlorobenzene (TNCB)-induced dermatitis in NC/Nga mice. This effect was nullified by pretreatment of the neurokinin-1 receptor (NK-1R) antagonist CP99994. SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as i...
4 CitationsSource
#1Maria Jose Dubon (Kyung Hee University)H-Index: 6
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook ParkH-Index: 18
view all 4 authors...
Transforming growth factor-beta (TGF-β) induces the migration and mobilization of bone marrow-derived mesenchymal stem cells (BM-MSCs) to maintain bone homeostasis during bone remodeling and facilitate the repair of peripheral tissues. Although many studies have reported the mechanisms through which TGF-β mediates the migration of various types of cells, including cancer cells, the intrinsic cellular mechanisms underlying cellular migration, and mobilization of BM-MSCs mediated by TGF-β are uncl...
27 CitationsSource