Diane E. Heck
New York Medical College
DNA damageMolecular biologyEnzymeChemistryImmunologyOxidative stressInflammationKeratinocyteNitric oxide synthaseSulfur mustardSuperoxideToxicityLung injuryReactive oxygen speciesp38 mitogen-activated protein kinasesNitric oxideBiochemistryMedicineBiologyCell biologyPharmacology
152Publications
38H-index
4,443Citations
Publications 142
Newest
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Marion K. Gordon (RU: Rutgers University)H-Index: 21
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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Sulfur mustard (SM; bis (2-chloroethyl) sulfide) is a potent vesicant which causes irritation of the conjunctiva and damage to the cornea. In the present studies, we characterized the ocular effects of SM in New Zealand white rabbits. Within one day of exposure to SM, edema and hazing of the cornea were observed, followed by neovascularization which persisted for at least 28 days. This was associated with upper and lower eyelid edema and conjunctival inflammation. The conjunctiva is composed of ...
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#1Diane E. Heck (NYMC: New York Medical College)H-Index: 38
#2Laurie B. Joseph (RU: Rutgers University)H-Index: 12
Last. Hong-Duck KimH-Index: 14
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Both inorganic mercury and organic mercury compounds, including methyl mercury and ethyl mercury, are noxious pollutants known to cause deleterious neurological and cardiovascular effects in humans and profoundly affect the brains and development of infants and children (for review see Bernhoft RA. J Environ Public Health, 2012; Jung-Duck Park, Wei Zheng. J Prev Med Public Health. 45(6):344–352, 2012; Charles TD, Robert PM, Hing MC, Daniel JJ, Nicola P. J Prev Med Public Health 45(6):344–352, 20...
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#1Shaojun Yang (RU: Rutgers University)H-Index: 3
#2Yi-Hua Jan (RU: Rutgers University)H-Index: 8
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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Reactive carbonyls such as diacetyl (2,3-butanedione) and 2,3-pentanedione in tobacco and many food and consumer products are known to cause severe respiratory diseases. Many of these chemicals are detoxified by carbonyl reductases in the lung, in particular, dicarbonyl/l-xylulose reductase (DCXR), a multifunctional enzyme important in glucose metabolism. DCXR is a member of the short-chain dehydrogenase/reductase (SDR) superfamily. Using recombinant human enzyme, we discovered that DCXR mediate...
10 CitationsSource
#1Barry Weinberger (Hofstra University)H-Index: 22
#2Rama Malaviya (RU: Rutgers University)H-Index: 14
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 71
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Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the pharynx, trachea and bronchioles, while long-term consequences include fibrosis and, in some instances, cancer. Current therapies to treat mustard poisoning are primarily palliative and do not target underlying pathophysiologic mechanisms. New knowledge about vesicant-induced pulmonary disease pathogenesis has...
21 CitationsSource
#1Michael P. Shakarjian (RU: Rutgers University)H-Index: 12
#2Marcela Laukova (NYMC: New York Medical College)H-Index: 15
Last. Libor Velíšek (NYMC: New York Medical College)H-Index: 27
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Incidences of pesticide poisonings are a significant cause of morbidity and mortality worldwide. The seizure-inducing rodenticide tetramethylenedisulfotetramine is one of the most toxic of these agents. Although banned, it has been responsible for thousands of accidental, intentional, and mass poisonings in mainland China and elsewhere. An optimal regimen for treatment of poisoning has not been established. Its facile synthesis from easily obtained starting materials, extreme potency, and lack o...
2 CitationsSource
#1Laurie B. Joseph (RU: Rutgers University)H-Index: 12
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Diane E. Heck (NYMC: New York Medical College)H-Index: 38
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In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. These proinflammatory mediators contribute to damaging th...
5 CitationsSource
#1Yi Hua Jan (RU: Rutgers University)H-Index: 3
#2Jason R. Richardson (NEOMED: Northeast Ohio Medical University)H-Index: 28
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl 4-nitrophenyl phosphate), a highly poisonous nerve agent and potent inhibitor of acetylcholinesterase. We have been investigating inhibitors of CYP-mediated bioactivation of OPs as a method of preventing or reversing progressive parathion toxicity. It is well recognize...
8 CitationsSource
#1Rama Malaviya (RU: Rutgers University)H-Index: 14
#2Vasanthi R. Sunil (RU: Rutgers University)H-Index: 20
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 71
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Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long-term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this a...
11 CitationsSource