Simone Sprio
National Research Council
Composite numberRegenerative medicineCeramicBiomedical engineeringComposite materialRegeneration (biology)NanotechnologyBiomineralizationChemistryMaterials scienceMineralogySinteringApatiteBone tissueBone regenerationChemical engineeringCrystallinityTissue engineeringCalciumScaffold
Publications 120
#1Anna Tampieri (National Research Council)H-Index: 53
#2Monica Sandri (National Research Council)H-Index: 32
Last. Simone Sprio (National Research Council)H-Index: 26
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The aging of the world population is increasingly claimed as an alarming situation, since an ever-raising number of persons in advanced age but still physically active is expected to suffer from invalidating and degenerative diseases. The impairment of the endogenous healing potential provoked by the aging requires the development of more effective and personalized therapies, based on new biomaterials and devices able to direct the cell fate to stimulate and sustain the regrowth of damaged or di...
1 CitationsSource
Last. Simone SprioH-Index: 26
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#1Elisa Mazzoni (University of Ferrara)H-Index: 19
#2Maria Rosa Iaquinta (University of Ferrara)H-Index: 5
Last. Fernanda Martini (University of Ferrara)H-Index: 4
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Over the past decades, age-related pathologies have increased abreast the aging population worldwide. Aging has highlighted the need for intervention with biomaterials / scaffolds on human damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body’s own regenerative mechanisms. In ti...
2 CitationsSource
#1Gloria Belén Ramírez-Rodríguez (UGR: University of Granada)H-Index: 9
#2Ana Rita PereiraH-Index: 2
Last. Monica SandriH-Index: 32
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In bone tissue engineering, the design of 3D systems capable of recreating composition, architecture and micromechanical environment of the native extracellular matrix (ECM) is still a challenge. While perfusion bioreactors have been proposed as potential tool to apply biomechanical stimuli, its use has been limited to a low number of biomaterials. In this work, we propose the culture of human mesenchymal stem cells (hMSC) in biomimetic mineralized recombinant collagen scaffolds with a perfusion...
#1Tatiana Patrício (National Research Council)H-Index: 8
#2Didem Mumcuoglu (EUR: Erasmus University Rotterdam)H-Index: 6
Last. Simone Sprio (National Research Council)H-Index: 26
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Abstract Hybrid superparamagnetic microspheres with bone-like composition, previously developed by a bio-inspired assembling/mineralization process, are evaluated for their ability to uptake and deliver recombinant human bone morphogenetic protein-2 (rhBMP-2) in therapeutically-relevant doses along with prolonged release profiles. The comparison with hybrid non-magnetic and with non-mineralized microspheres highlights the role of nanocrystalline, nanosize mineral phases when they exhibit surface...
#1Giada Bassi (National Research Council)H-Index: 1
#2Silvia Panseri (National Research Council)H-Index: 25
Last. Monica Montesi (National Research Council)H-Index: 17
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The failure of the osteosarcoma conventional therapies leads to the growing need for novel therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population has been recently identified as the main limitation in the current therapies. Moreover, the traditional two-dimensional (2D) in vitro models, employed in the drug testing and screening as well as in the study of cell and molecular biology, are affected by a poor in vitro-in vivo translation ability. To overcome thes...
Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold...
2 CitationsSource
#1Roberto ToniH-Index: 15
#2Giusy Di Conza (University of Parma)H-Index: 1
Last. Anna TampieriH-Index: 53
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Osteoporosis stems from an unbalance between bone mineral resorption and deposition. Among the numerous cellular players responsible for this unbalance bone marrow (BM) monocytes/macrophages, mast cells, T and B lymphocytes, and dendritic cells play a key role in regulating osteoclasts, osteoblasts, and their progenitor cells through interactions occurring in the context of the different bone compartments (cancellous and cortical). Therefore, the microtopography of immune cells inside trabecular...
1 CitationsSource
#1Simone Sprio (National Research Council)H-Index: 26
#2Massimiliano Dapporto (National Research Council)H-Index: 6
Last. Anna Tampieri (National Research Council)H-Index: 53
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In the present work, hydroxyapatite nanoparticles (HA) doped with Mg2+, Sr2+ and Zn2+ ions are developed by wet neutralization method and then sintered at 1250 °C to obtain bulk consolidated materials. Physicochemical and microstructural analyses show that the presence of ion doping in the HA structure induced the formation of betaTCP as secondary phase, during the sintering process, and we found that this effect is depending on the solubility and stability of the various doping ions in the hydr...
2 CitationsSource
#1Stefania Scialla (National Research Council)H-Index: 1
#1Stefania Scialla (National Research Council)H-Index: 4
Last. Clara Piccirillo (National Research Council)H-Index: 28
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Fish industry by-products constitute an interesting platform for the extraction and recovery of valuable compounds in a circular economy approach. Among them, mussel shells could provide a calcium-rich source for the synthesis of hydroxyapatite (HA) bioceramics. In this work, HA nanoparticles have been successfully synthesized starting from mussel shells (Mytilus edulis) with a two steps process based on thermal treatment to convert CaCO3 in CaO and subsequent wet precipitation with a phosphorus...