Patrick Couvreur
Université Paris-Saclay
ProdrugBiophysicsDrug carrierNanoparticleNanotechnologyLiposomeChemistryPolymer chemistryMaterials scienceIn vitroIn vivoDrug deliveryDrugChemical engineeringChromatographyPolymerBiochemistryMedicineDosage formBiologyPharmacology
Publications 629
#1Vincent Pautu (Université Paris-Saclay)
#2Heng Zhao ('ENS Paris': École Normale Supérieure)H-Index: 1
Last. Simona Mura (Université Paris-Saclay)H-Index: 26
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Biocompatible nanoscale iron carboxylate metal organic frameworks (nanoMOFs) already demonstrated their ability to efficiently deliver various therapeutic molecules. The versatility of the synthetic methods and functionalization strategies could further improve their drug carrier potential. However, in oncology, preclinical evaluation still suffers from the lack of relevant models able to mimic the heterogeneity and the microenvironment of human tumors. This may impact the significance of the pr...
This « Magnum Opus » emphasizes that serendipity is a corner stone in research. The paths of discovery and innovation often result from the interdisciplinarity of scientific areas that are a priori disconnected from each other. In the 1970s, fundamental discoveries in cell biology led to unexpected advances in galenic pharmacy with the emergence of nanotechnologies for the intracellular delivery of non diffusing molecules. As well, fluorescein-loaded polyacrylamide nanocapsules were shown to del...
The COVID-19 pandemic occurred in the context of a dramatic decline in support for biological and health research in France. An analysis of resources shows that the credits allocated to it in 2020 correspond to only 17.2% of the total allocated to research, the lowest ratio for at least 15 years.Another weakness of the hospital research support system is the way in which national health insurance credits are allocated. Bringing it into line with international best practices would mean entrusting...
#1Arnold Migus (Académie Nationale de Médecine)H-Index: 1
#2Raymond Ardaillou (Académie Nationale de Médecine)H-Index: 5
Last. P. Netter (Académie Nationale de Médecine)H-Index: 1
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Resume null null Le sous-financement de la recherche en biologie-sante par le ministere en charge de la recherche et l’inadequation de l’attribution des credits provenant de l’assurance maladie pour le soutien a la recherche hospitaliere ont fait l’objet d’un premier article. Il serait toutefois illusoire d’esperer qu’une action uniquement budgetaire resolve les difficultes observees si une reorganisation n’etait pas envisagee. L’objectif doit etre de simplifier et gagner en efficience. Aussi, q...
#1Jean-Pierre GoulléH-Index: 21
#2Patrick Couvreur (Université Paris-Saclay)H-Index: 127
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#1Hassan Rammal (URCA: University of Reims Champagne-Ardenne)H-Index: 8
#2Almar Al Assaad (URCA: University of Reims Champagne-Ardenne)
Last. Abdelilah Beljebbar (URCA: University of Reims Champagne-Ardenne)H-Index: 13
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Intracellular distribution of doxorubicin (DOX) and its squalenoylated (SQ-DOX) nanoparticles (NPs) form in murine lung carcinoma M109 and human breast carcinoma MDA-MB-231 cells were investigated by Raman microspectroscopy. Pharmacological data showed that DOX induced higher cytotoxic effect than SQ-DOX NPs. Raman data were obtained using single-point measurements and imaging on the whole cell areas. These data showed that after DOX treatment at 1μM, the spectral features of DOX were not detect...
#1Eleonore Coppens (Université Paris-Saclay)
#2Didier Desmaële (Université Paris-Saclay)H-Index: 33
Last. Simona Mura (Université Paris-Saclay)H-Index: 26
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A small library of amphiphilic prodrugs has been synthesized by conjugation of gemcitabine (Gem) (a hydrophilic nucleoside analogue) to a series of lipid moieties and investigated for their capacity to spontaneously self-assemble into nanosized objects by simple nanoprecipitation. Four of these conjugates formed stable nanoparticles (NPs), while with the others, immediate aggregation occurred, whatever the tested experimental conditions. Whether such capacity could have been predicted based on t...
#1Suzan Boutary (Université Paris-Saclay)H-Index: 2
#2Marie Caillaud (Université Paris-Saclay)H-Index: 2
Last. Didier Desmaële (Université Paris-Saclay)H-Index: 33
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Charcot-Marie-Tooth disease type 1 A (CMT1A) lacks an effective treatment. We provide a therapy for CMT1A, based on siRNA conjugated to squalene nanoparticles (siRNA PMP22-SQ NPs). Their administration resulted in normalization of Pmp22 protein levels, restored locomotor activity and electrophysiological parameters in two transgenic CMT1A mouse models with different severity of the disease. Pathological studies demonstrated the regeneration of myelinated axons and myelin compaction, one major st...
2 CitationsSource
#1Julie Mougin (Université Paris-Saclay)H-Index: 19
#2Claudie Bourgaux (Université Paris-Saclay)H-Index: 3
Last. Patrick Couvreur (Université Paris-Saclay)H-Index: 127
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Abstract Self-assembled cylindrical aggregates made of amphiphilic molecules emerged almost 40 years ago. Due to their length up to micrometers, those particles display original physico-chemical properties such as important flexibility and, for concentrated samples, a high viscoelasticity making them suitable for a wide range of industrial applications. However, a quarter of century was needed to successfully take advantage of those improvements towards therapeutic purposes. Since then, a wide d...