Wojciech Bik
NeuropeptideInternal medicineEndocrinologyReceptorAdipose tissueChemistryAdipokineAdiponectinInflammationHypothalamusCartInsulin resistanceDiseaseInsulinCorticosteroneMetabolic syndromeLeptinMultiple sclerosisObesityCentral nervous systemHormoneMedicineBiology
71Publications
13H-index
483Citations
Publications 72
Newest
#1Anita Domańska (Warsaw University of Life Sciences)H-Index: 1
#2Arkadiusz Orzechowski (Warsaw University of Life Sciences)H-Index: 21
Last. Agnieszka Baranowska-BikH-Index: 14
view all 6 authors...
Alzheimer’s disease (AD) is the most common form of dementia with a growing incidence rate primarily among the elderly. It is a neurodegenerative, progressive disorder leading to significant cognitive loss. Despite numerous pieces of research, no cure for halting the disease has been discovered yet. Phytoestrogens are nonestradiol compounds classified as one of the endocrine-disrupting chemicals (EDCs), meaning that they can potentially disrupt hormonal balance and result in developmental and re...
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Alzheimer’s disease (AD) is the most common form of neurodegenerative dementia. Metabolic disorders including obesity and type 2 diabetes mellitus (T2DM) may stimulate amyloid β (Aβ) aggregate formation. AD, obesity, and T2DM share similar features such as chronic inflammation, increased oxidative stress, insulin resistance, and impaired energy metabolism. Adiposity is associated with the pro-inflammatory phenotype. Adiposity-related inflammatory factors lead to the formation of inflammasome com...
1 CitationsSource
#1Małgorzata KaliszH-Index: 12
Last. Anna LitwiniukH-Index: 5
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All-trans-retinoic acid (atRA), an active metabolite of vitamin A, exerts a potential role in the prevention of cardiovascular diseases. It has been shown that atRA ameliorates atherosclerosis while the exact mechanism underlying this protection remains unknown. This study investigated the influence of atRA on insulin resistance (IR), atherosclerosis, and the process of perivascular adipose tissue (PVAT) browning. Moreover, syntheses of adiponectin, adipokine with anti-atherogenic effects, and t...
1 CitationsSource
#1Lidia MartynskaH-Index: 15
#2Alina Gajewska (PAN: Polish Academy of Sciences)H-Index: 14
Last. Boguslawa Baranowska (Medical University of Warsaw)H-Index: 17
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Introduction. Orexin A is a neuropeptide synthesized in the lateral hypothalamus. Orexin A immunoreactive fibers overlap distribution with GnRH neurons. In adult rats, orexin A is known to affect LH secretion via GnRH release modulation. Since data concerning orexin A impact on the hypothalamo-pituitary axis activity are limited, we focused on orexin A and receptors of NPY involvement in the modulation of LH release and LH subunit β mRNA expression in prepubertal female rats. Material and method...
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A growing number of patients suffer from autoimmune diseases, including autoimmune thyroid disease. There has simultaneously been a significant increase in the prevalence of obesity worldwide. It is still an open question whether adiposity can directly influence activation of inflammatory processes affecting the thyroid in genetically predisposed individuals. Adipokines, biologically active substances derived from the adipocytes, belong to a heterogenic group of compounds involved in numerous ph...
1 CitationsSource
Leptin is an adipokine, adipocyte-derived compound, which acts both as a hormone and cytokine. It is mainly synthesized by adipocytes of white adipose tissue. Leptin possesses pleiotropic functions including, among others, stimulation of angiogenesis and production of proinflammatory cytokines. The various types of leptin activity are related to the wide distribution of leptin receptors. This adipokine acts by activating intracellular signaling cascades such as JAKs (Janus kinases), STATs (signa...
2 CitationsSource
#1Wojciech BikH-Index: 13
#2Klaudia DopytalskaH-Index: 3
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#1Anna LitwiniukH-Index: 5
#2Anita Domańska (Warsaw University of Life Sciences)H-Index: 1
Last. Małgorzata KaliszH-Index: 12
view all 6 authors...
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Amyloid β- (Aβ-) induced mitochondrial dysfunction may be a primary process triggering all the cascades of events that lead to AD. Therefore, identification of natural factors and endogenous mechanisms that protect neurons against Aβ toxicity is needed. In the current study, we investigated whether alpha-linolenic acid (ALA), as a natural product, would increase insulin and IGF-I (insulin-like growth factor I) release from a...
5 CitationsSource
#2Dorota Uchman (Medical University of Warsaw)H-Index: 3
Last. Jan Kochanowski (Medical University of Warsaw)H-Index: 8
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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact etiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet resulting in obesity and metabolic syndrome can contribute to this disease. Adipokines, secreted by adipose tissue, are linking metabolism and immune system. We aimed to assess plasma levels of selected adipokines in newly diagnosed, treatment-naive individuals with multiple ...
1 CitationsSource
: Insulin was discovered in 1922 by Banting and Best. Since that time, extensive research on the mechanisms of insulin activity and action has continued. Currently, it is known that the role of insulin is much greater than simply regulating carbohydrate metabolism. Insulin in physiological concentration is also necessary to maintain normal vascular function. Insulin resistance is defined as a pathological condition characterized by reduced sensitivity of skeletal muscles, liver, and adipose tiss...
4 CitationsSource