Paulus Kirchhof
University of Birmingham
Internal medicineEndocrinologyRepolarizationCardiologyRandomized controlled trialIntensive care medicineSinus rhythmCatheter ablationCardioversionHeart failureAtrial fibrillationMEDLINEElectrocardiographyHeart diseaseManagement of atrial fibrillationPopulationIn patientAnesthesiaStrokeMedicine
Publications 662
#1Artak KhachatryanH-Index: 2
#2José L. MerinoH-Index: 26
Last. Lamiae Grimaldi-Bensouda (French Institute of Health and Medical Research)H-Index: 18
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AIMS To evaluate the effectiveness and safety of dronedarone compared with other commonly used antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrences. METHODS AND RESULTS An international observational cohort study in Germany, Spain, Italy, and the USA enrolling patients with AF receiving AAD therapy. Patients with New York Heart Association (NYHA) Class IV heart failure were excluded. Participants were followed for up to 18 months, regardless of discontinuation or subse...
#1Paulus Kirchhof (University of Birmingham)H-Index: 110
Fibroblasts contribute to approximately 20% of the non-cardiomyocytic cells in the heart. They play important roles in the myocardial adaption to stretch, inflammation, and other pathophysiological conditions. Fibroblasts are a major source of extracellular matrix (ECM) proteins whose production is regulated by cytokines, such as TNF-α or TGF-β. The resulting myocardial fibrosis is a hallmark of pathological remodeling in dilated cardiomyopathy (DCM). Therefore, in the present study, the secreto...
#1Fabian Moser (UHH: University of Hamburg)H-Index: 4
#2Laura Rottner (UHH: University of Hamburg)H-Index: 11
Last. Andreas Metzner (UHH: University of Hamburg)H-Index: 45
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INTRODUCTION Cryoballoon (CB) ablation for pulmonary vein isolation (PVI) is an effective treatment of atrial fibrillation (AF). Recently, a novel cryoablation system was introduced. The aim of the study was to compare the safety, efficacy and biophysical characteristics of a novel cryoablation system (POLARx™; Boston Scientific) to a commonly used and clinically well characterized system (Arctic Front Advance Pro™, AFA; Medtronic). METHODS AND RESULTS Fifty consecutive patients with symptomatic...
#2Elena Arbelo (University of Barcelona)H-Index: 31
Last. Luigi TavazziH-Index: 138
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BACKGROUND The current practice of atrial fibrillation ablation (AFA) as a treatment option for atrial fibrillation (AF) in patients with heart failure (HF) across Europe, their clinical profiles and outcomes is still undefined. METHODS The European Society of Cardiology (ESC) led a prospective observational registry of consecutive patients undergoing AFA, in 27 member countries. The subgroup of patients with HF, followed-up for 1 year, was analyzed and the results are reported. RESULTS Of the 3...
#1Tilo ThottakaraH-Index: 1
#2Natalie LundH-Index: 6
Last. Monica PattenH-Index: 10
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(1) Background: Left ventricular hypertrophy, myocardial disarray and interstitial fibrosis are the hallmarks of hypertrophic cardiomyopathy (HCM). Access to the myocardium for diagnostic purposes is limited. Circulating biomolecules reflecting the myocardial disease processes could improve the early detection of HCM. Circulating miRNAs have been found to reflect disease processes in several cardiovascular diseases. (2) Methods: We quantified circulating miRNA molecules in the plasma of 24 HCM a...
Background: Right ventricular dysfunction is a major determinant of outcome in pulmonary arterial hypertension (PAH). We aimed to identify echocardiographic right heart parameters associated with adverse outcome and to develop a non-invasive, echocardiography-based risk score for PAH patients. Methods and Results: In 254 PAH patients we analyzed functional status, laboratory results, and echocardiographic parameters. We included these parameters to estimate all-cause death or lung transplantatio...
#1Harish Sharma (University of Birmingham)H-Index: 1
#2Ashwin Radhakrishnan (University of Birmingham)H-Index: 6
Last. Jonathan N. Townend (University of Birmingham)H-Index: 57
view all 15 authors...
Mitral regurgitation (MR) following acute myocardial infarction (AMI) worsens prognosis and reports of prevalence vary significantly. The objective was to determine prevalence, risk factors, and outcomes related to MR following AMI. We identified 1000 consecutive patients admitted with AMI in 2016/17 treated by percutaneous coronary intervention with pre-discharge transthoracic echocardiography. MR was observed in 294 of 1000 (29%), graded as mild (n = 224 [76%]), moderate (n = 61 [21%]) and sev...
#1Hanna BräuningerH-Index: 1
#2Bastian StoffersH-Index: 1
Last. Diana LindnerH-Index: 18
view all 23 authors...
AIMS Cardiac involvement in COVID-19 is associated with adverse outcome. However, it is unclear whether cell specific consequences are associated with cardiac SARS-CoV-2 infection. Therefore, we investigated heart tissue utilizing in situ hybridization, immunohistochemistry and RNA-sequencing in consecutive autopsy cases to quantify virus load and characterize cardiac involvement in COVID-19. METHODS AND RESULTS In this study, 95 SARS-CoV-2-positive autopsy cases were included. A relevant SARS-C...
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