Oliver Strobel
Heidelberg University
CancerInternal medicineSurgeryPathologyOncologyCardiothoracic surgeryPancreatitisPancreatic diseaseVascular surgeryPancreatectomyPancreasAbdominal surgeryPancreatic cancerAdenocarcinomaTransplant surgeryPerioperativeCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 391
#1Pascal Probst (Heidelberg University)H-Index: 22
#2Felix J Hüttner (Heidelberg University)H-Index: 16
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
#1Christine Tjaden (University Hospital Heidelberg)H-Index: 12
#2Ulf HinzH-Index: 64
Last. Christoph BerchtoldH-Index: 5
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Objective null Evaluation of the outcome after resection for distal bile duct cancer (DBC) with focus on the impact of microscopic histopathological resection status R0 (>1 mm) vs R1 (≤1 mm) vs R1 (direct). null Summary background data null DBC is a rare disease for which oncologic resection offers the only chance of cure. null Methods null Prospectively collected data of consecutive patients undergoing pancreaticoduodenectomy for DBC were analyzed. Histopathological resection status was classif...
#1Christine Tjaden (University Hospital Heidelberg)H-Index: 12
#2M. Sandini (University Hospital Heidelberg)H-Index: 1
Last. Markus W. Büchler (University Hospital Heidelberg)H-Index: 173
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Importance The natural history of intraductal papillary mucinous neoplasms (IPMNs) remains uncertain. The inconsistencies among published guidelines preclude accurate decision-making. The outcomes and potential risks of a conservative watch-and-wait approach vs a surgical approach must be compared. Objective To provide an overview of the surgical management of IPMNs, focusing on the time of resection. Design, Setting, and Participants This cohort study was conducted in a single referral center; ...
1 CitationsSource
#1Markus K. Diener (Heidelberg University)H-Index: 48
#2André L. Mihaljevic (Heidelberg University)H-Index: 20
Last. Markus W. Büchler (Heidelberg University)H-Index: 173
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Abstract Background Modern pancreatic cancer surgery changed with the introduction of effective neoadjuvant therapies. Complete tumor resection is the mainstay for long-term, disease-free, and overall survival and has been a prerequisite for decreasing local recurrence. The medial resection margin in the area of the superior mesenteric vessels limits the radicalness of the resection, especially in borderline and locally advanced cases. Therefore, the periarterial soft tissue around the peripancr...
8 CitationsSource
#1Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
#2C. Corradi (UniPi: University of Pisa)H-Index: 1
Last. Gabriele Capurso (UniSR: Vita-Salute San Raffaele University)H-Index: 56
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Although pancreatic ductal adenocarcinoma (PDAC) survival is poor, there are differences in patients' response to the treatments. Detection of predictive biomarkers explaining these differences is of the utmost importance. In a recent study two genetic markers (CD44-rs353630 and CHI3L2-rs684559) were reported to be associated with survival after PDAC resection. We attempted to replicate the associations in 1856 PDAC patients (685 resected with stage I/II) from the PANcreatic Disease ReseArch (PA...
#1Fabian SchuhH-Index: 1
Last. Markus W. BüchlerH-Index: 173
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OBJECTIVE The aim of this study was to develop a classification system for pancreas-associated risk factors in pancreatoduodenectomy (PD). SUMMARY BACKGROUND DATA Postoperative pancreatic fistula (POPF) is the most relevant PD-associated complication. A simple standardized surgical reporting system based on pancreas- associated risk factors is lacking. METHODS A systematic literature search was conducted to identify studies investigating clinically relevant POPF (CR-POPF) and pancreas-associated...
1 CitationsSource
#1Martin Loos (University Hospital Heidelberg)H-Index: 2
#1Martin LoosH-Index: 14
Last. Markus W. BüchlerH-Index: 173
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OBJECTIVE The aim of this study was to determine the role of gastric venous congestion (GVC) in mortality after total pancreatectomy (TP). BACKGROUND Data from a nationwide administrative database revealed that TP is associated with a 23% mortality rate in Germany. METHODS A total of 585 consecutive patients who had undergone TP (n = 514) or elective completion pancreatectomy (n = 71) between January 2015 and December 2019 were analyzed. Univariable and multivariable analyses were performed to i...
#1Thomas HankH-Index: 11
#2Ulf HinzH-Index: 64
Last. Oliver StrobelH-Index: 50
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Objective To develop and validate a pretreatment prognostic score in pancreatic cancer (PDAC). Background Pretreatment prognostication in PDAC is important for treatment decisions but remains challenging. Available prognostic tools are derived from selected cohorts of patients who underwent resection, excluding up to 20% of patients with exploration only, and do not adequately reflect the pretreatment scenario. Methods Patients undergoing surgery for PDAC in Heidelberg from 07/2006 to 06/2014 we...
#1Elisa Espinet (DKFZ: German Cancer Research Center)H-Index: 7
#2Zuguang Gu (DKFZ: German Cancer Research Center)H-Index: 20
Last. Andreas Trumpp (DKFZ: German Cancer Research Center)H-Index: 74
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Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia, which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified epithelial cells from human PDAC and normal pancreas and derived their genome-wide transcriptome and DNA methylome landscapes. Clustering based on DNA methylation revealed two distinct PDAC groups displaying different methylation patterns at regions encoding repeat elements. Methylationlow tumors are characterized by higher expres...
2 CitationsSource