Munehiro Teranishi
Daiichi Sankyo
Internal medicineEndocrinologyPathologyGene expressionMolecular biologyEndoplasmic reticulumFetusChemistryApoptosisImmunologyImmunohistochemistryPlacentaToxinCytokeratinFemurToxicityProgrammed cell deathNecrosisThyroidHistopathologyHormoneMedicineBiologyPharmacology
55Publications
11H-index
459Citations
Publications 54
Newest
#1Makoto Shirai (Daiichi Sankyo)H-Index: 4
#2Shingo Arakawa (Daiichi Sankyo)H-Index: 11
Last. Kiyonori Kai (Daiichi Sankyo)H-Index: 7
view all 4 authors...
We previously reported that thioacetamide (TA)-induced hepatocellular necrosis was attenuated in mice fed a high-fat diet (HFD mice) compared with mice fed a normal rodent diet (ND mice). In this study, we investigated whether p38 mitogen-activated protein kinase (p38 MAPK) was involved in this attenuation. Western blot analysis revealed that hepatic phosphorylated p38 MAPK protein decreased at 8 and 24 hours (hr) after TA dosing in the HFD mice, while it decreased only at 24 hr in the ND mice i...
2 CitationsSource
#1Isao Igarashi (Daiichi Sankyo)H-Index: 3
#2Toshihiko Makino (Daiichi Sankyo)H-Index: 4
Last. Kazuhisa Furuhama (Gidai: Gifu University)H-Index: 9
view all 7 authors...
We examined the localization of connexin 32 (Cx32), a component of gap junctions, in 24-month-old male B6C3F1 mice with spontaneously occurring hepatocellular altered foci or tumors. Immunohistochemically, Cx32-staining intensity in cell-to-cell membranes of altered hepatocytes was decreased in eosinophilic foci and increased in basophilic foci as compared to those in intact hepatocytes. These alterations were enhanced in adenomas and carcinomas with both eosinophilic and basophilic cytoplasm. I...
Source
#1Makoto Shirai (Daiichi Sankyo)H-Index: 4
#2Miho Matsuoka (Daiichi Sankyo)H-Index: 1
Last. Wataru Takasaki (Daiichi Sankyo)H-Index: 8
view all 6 authors...
: We previously reported that hepatic necrosis induced by thioacetamide (TA), a hepatotoxicant, was attenuated in mice fed a high-fat diet (HFD mice) in comparison with mice fed a normal rodent diet (ND mice). In this study, we focused on investigation of the mechanism of the attenuation. Hepatic content of thiobarbituric acid reactive substances (TBARS), an oxidative stress marker, significantly increased in ND mice at 24 and 48 hr after TA administration in comparison to that in vehicle-treate...
3 CitationsSource
#1Isao Igarashi (Daiichi Sankyo)H-Index: 3
#2Takanori Maejima (Daiichi Sankyo)H-Index: 6
Last. Atsushi Sanbuissho (Daiichi Sankyo)H-Index: 11
view all 6 authors...
Abstract Gap junctional intercellular communication (GJIC), by which glutathione (GSH) and inorganic ions are transmitted to neighboring cells, is recognized as being largely involved in toxic processes of chemicals. We examined acetaminophen (APAP)-induced hepatotoxicity clinicopathologically using male wild-type mice and mice lacking the gene for connexin32, a major gap junction protein in the liver [knockout (Cx32KO) mice]. When APAP was intraperitoneally administered at doses of 100, 200, or...
18 CitationsSource
#1Makoto Shirai (Daiichi Sankyo)H-Index: 4
#2Shingo Arakawa (Daiichi Sankyo)H-Index: 11
Last. Munehiro Teranishi (Daiichi Sankyo)H-Index: 11
view all 8 authors...
To assess modification of thioacetamide-induced hepatotoxicity in mice fed a high-fat diet, male C57BL/6J mice were fed a normal rodent diet or a high-fat diet for 8 weeks and then treated once intraperitoneally with thioacetamide at 50 mg/kg body weight. At 24 and 48 hours after administration, massive centrilobular hepatocellular necrosis was observed in mice fed the normal rodent diet, while the necrosis was less severe in mice fed the high-fat diet. In contrast, severe swelling of hepatocyte...
8 CitationsSource
#1Kiyonori Kai (Daiichi Sankyo)H-Index: 7
#2Takashi Yamaguchi (Daiichi Sankyo)H-Index: 55
Last. Wataru Takasaki (Daiichi Sankyo)H-Index: 8
view all 6 authors...
A sensitive urinary biomarker for acute kidney injury (AKI) was investigated in beagle dogs with nephrotoxicity induced by gentamicin. Gentamicin sulphate at 25 or 50 mg/kg was injected (s.c.) for 9 days, and conventional urinalysis, ELISA assay of neutrophil gelatinase-associated lipocal (NGAL) in urine, blood chemistry, and pathological examinations were performed. The dog given gentamicin at 25 mg/kg only showed slight deposition of lysosomal granules in the proximal tubular epithelium of the...
39 CitationsSource
#1Isao Igarashi (Daiichi Sankyo)H-Index: 3
#2Toshihiko Makino (Daiichi Sankyo)H-Index: 4
Last. Kazuhisa Furuhama (Gidai: Gifu University)H-Index: 16
view all 7 authors...
Connexin 32 (Cx32) is a major gap junction protein in the liver. Neoplastic and non-neoplastic lesions were examined in Cx32-deficient (Cx32KO) mice maintained for 24-month, and compared with those in wild-type mice as a corresponding control. In neoplastic lesions, hepatocellular carcinoma increased significantly only in male Cx32KO mice, suggesting that Cx32 deficiency may be related to their pathogenesis. For females, the incidence of pituitary adenoma in the pars distalis of Cx32KO mice was ...
13 CitationsSource
#1Makoto ShiraiH-Index: 4
#2Kiyonori KaiH-Index: 5
Last. Atsushi SanbuisshoH-Index: 11
view all 8 authors...
A nodule was observed in the adrenal medulla of a twenty-week-old male Wistar Hannover rat. The nodule was predominantly (over 80%) composed of neural components, with ganglion cells scattered in sparse supporting tissue containing nerve fibers and Schwann cells. In the peripheral area of the tumor, atypical chromaffin cells were also observed. Accumulation of eosinophilic serous fluid was also noted in the stromal tissue. There were neither mitotic figures in the ganglion cells nor necrotic foc...
1 CitationsSource
#1Takuya Matsuyama (Daiichi Sankyo)H-Index: 8
#2Noriyo Niino (Daiichi Sankyo)H-Index: 8
Last. Atsushi Sanbuissho (Daiichi Sankyo)H-Index: 11
view all 6 authors...
Abstract Rats were treated with a single oral dose of 10, 25 and 50 mg/kg of 1,3-dinitrobenzene (DNB), and the testis was subjected to a GeneChip microarray analysis. A total of 186 and 304 gene probe sets were up- and down-regulated, respectively, by the DNB treatment, where spermatocyte death and Sertoli cell vacuolation in testis and increased debris of spermatogenic cell in epididymis were noted. The expression profile for four sets of genes were investigated, whose expressions are reported ...
8 CitationsSource
#1Makoto Shirai (Daiichi Sankyo)H-Index: 4
#2Takanori Maejima (Daiichi Sankyo)H-Index: 6
Last. Atsushi Sanbuissho (Daiichi Sankyo)H-Index: 11
view all 8 authors...
Multiple whitish nodules in the thoracic cavity at the site of the thymus were observed in a 101-week-old male ICR mouse. In a histopathological examination, the neoplastic cells were predominantly fusiform in shape and proliferated in sarcomatoid growth patterns. Some neoplastic cells showed epithelial growth patterns, such as the ductal structures. Mitotic figures were frequently seen, and small necrotic foci and invasion to adjacent thoracic organs were noted. In Alcian blue staining, bluish ...
3 CitationsSource