Koichi Waseda
Okayama University
Internal medicineChemokinePulmonary complianceEtiologySurgeryPathologyReceptorImmunologyAsthmaPancreatic elastaseInflammationOvalbuminEosinophiliaLungNeutrophiliaBronchoalveolar lavageRAGE (receptor)CytokineElastaseAirway hyperresponsivenessMedicineGastroenterology
36Publications
9H-index
271Citations
Publications 36
Newest
#1Genyo Ikeda (Okayama University)H-Index: 7
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Arihiko KanehiroH-Index: 25
view all 11 authors...
The incidence of overlapping bronchial asthma and chronic obstructive pulmonary disease has increased in recent years. Cysteinyl leukotrienes (CysLTs) play an important role in asthma, and the type 1 CysLT receptor (CysLT1R) is expressed by many inflammatory cells. We evaluated the effect of montelukast, a CysLT1R antagonist, on mouse models of asthma, porcine pancreatic elastase (PPE)-induced emphysema, and asthma combined with emphysema. Mice were sensitized with ovalbumin (OVA) on Days 0 and ...
19 CitationsSource
#1Hikari Koga (Okayama University)H-Index: 8
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 11 authors...
Background Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. In this study, we have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and c...
41 CitationsSource
#1Etsuko Kurimoto (Okayama University)H-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 13 authors...
Background Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it’s role in the inflammatory response of elastase-induced emphysema remains unclear.
73 CitationsSource
May 1, 2012 in ATS (American Thoracic Society International Conference)
#1Akihiko Taniguchi (Okayama University)H-Index: 10
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 11 authors...
Source
May 1, 2012 in ATS (American Thoracic Society International Conference)
#1Etsuko Kurimoto (Okayama University)H-Index: 6
#2Arihiko Kanehiro (Okayama University)H-Index: 25
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 10 authors...
Source
#1Yasuko Fuchimoto (Okayama University)H-Index: 9
#2Arihiko KanehiroH-Index: 25
Last. Mitsune TanimotoH-Index: 68
view all 11 authors...
Chemokine receptor (CCR) 5 is expressed on dendritic cells, macrophages, CD8 cells, memory CD4 T cells, and stromal cells, and is frequently used as a marker of T helper type 1 cells. Interventions that abrogate CCR5 or interfere with its ligand binding have been shown to alter T helper type 2–induced inflammatory responses. The role of CCR5 on allergic airway responses is not defined. CCR5-deficient (CCR5−/−) and wild-type (CCR5+/+) mice were sensitized and challenged with ovalbumin (OVA) and a...
14 CitationsSource
#1Koichi WasedaH-Index: 9
#2Yasushi Tanimoto (Okayama University)H-Index: 21
Last. Mitsune TanimotoH-Index: 68
view all 12 authors...
Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt ti...
4 CitationsSource
#1Koichi WasedaH-Index: 9
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Erwin W. Gelfand (University of Colorado Denver)H-Index: 113
view all 11 authors...
Most of the studies investigating the effectiveness of blocking the leukotriene B4 (LTB4) receptor 1 (BLT1) have been performed in models of primary or acute allergen challenge. The role of the LTB4-BLT1 pathway in secondary challenge models, where airway hyperresponsiveness (AHR) and airway inflammation have been established, has not been defined. We investigated the effects of blocking BLT1 on early- and late-phase development of AHR and airway inflammation in previously sensitized and challen...
14 CitationsSource
#1Koichi WasedaH-Index: 9
#2Yasushi Tanimoto (Okayama University)H-Index: 21
Last. Mitsune TanimotoH-Index: 68
view all 10 authors...
Churg-Strauss syndrome (CSS) is a granulomatous necrotizing vasculitis of unknown etiology associated with bronchial asthma. Despite affecting small to medium-sized vessels, necrosis of the digits due to vasculitis is extremely rare. We report a case of CSS with necrosis of the toe tips. A 37-year-old woman with asthma, who had been diagnosed with CSS 2 years ago, was admitted to our hospital with an exacerbation of CSS. The patient had a high grade fever and complained of abdominal pain and num...
4 CitationsSource
May 1, 2011 in ATS (American Thoracic Society International Conference)
#1Koichi Waseda (Okayama University)H-Index: 9
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 13 authors...
Source