Koichi Waseda
Okayama University
AirwayInternal medicineChemokinePulmonary complianceSurgeryPathologyReceptorImmunologyAsthmaPancreatic elastaseInflammationOvalbuminEosinophiliaLungNeutrophiliaBronchoalveolar lavageRAGE (receptor)CytokineElastaseAirway hyperresponsivenessMedicineGastroenterology
36Publications
9H-index
265Citations
Publications 36
Newest
#1Akemi Ando (Okayama University)H-Index: 2
#2Hideharu Hagiya (Osaka University)H-Index: 14
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 8 authors...
: We herein report the first documented case of acute hypersensitivity pneumonitis in which Candida guilliermondii was the possible causative organism. A young Japanese woman presented to our hospital with relapsing respiratory symptoms accompanied by high fever. A detailed interview revealed that the onset of the symptoms occurred shortly after using a humidifier in her home. Her symptoms showed spontaneous improvement soon after admission, and an examination of her bronchoalveolar lavage fluid...
2 CitationsSource
#1Utako Fujii (Okayama University)H-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 12 authors...
Background Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners—e.g., retinoic acid receptors (RARs), vitamin D receptors (VDRs), liver X receptors (LXRs), and peroxisome proliferator-activated receptors (PPARs). The NR family was recently associated with allergic diseases, but the role of RXRs in allergen-induc...
13 CitationsSource
#1Utako FujiiH-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko KanehiroH-Index: 25
view all 13 authors...
We recently reported that IL-17A plays a critical role in the development of porcine pancreatic elastase (PPE)–induced emphysema. The proliferation of T-helper type 17 (Th17) cells was induced by IL-23. To determine the contribution of IL-23 to the development of pulmonary emphysema, a mouse model of PPE-induced emphysema was used in which responses of IL-23p19–deficient (IL-23−/−) and wild-type (WT) mice were compared. Intratracheal instillation of PPE induced emphysematous changes in the lungs...
10 CitationsSource
#1Utako Fujii (Okayama University)H-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 11 authors...
RATIONALE: We have recently reported that IL-17A plays a critical role to the development of porcine pancreatic elastase (PPE)-induced emphysema. The proliferation of Th17 cells is induced by IL-23, however, the role of IL-23 in pulmonary emphysema remains uncertain. METHODS: Using a murine model of PPE-induced pulmonary emphysema, we assessed IL-23p19-deficient (IL-23-/-) mice and wild type (WT) mice. Intra-tracheal instillation of PPE induced increased emphysematous change of the lungs on day ...
Source
#1Koichi WasedaH-Index: 9
#2Kazuki Ocho (Okayama University)H-Index: 2
Last. Fumio OtsukaH-Index: 35
view all 9 authors...
KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering...
2 CitationsSource
#1Hideharu Hagiya (Okayama University)H-Index: 14
#2Eri Nakamura (Okayama University)H-Index: 13
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 10 authors...
1 CitationsSource
#1Akihiko Taniguchi (Okayama University)H-Index: 10
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 12 authors...
The receptor for advanced glycation end-products (RAGE) is a multiligand receptor that belongs to the immunoglobulin superfamily. RAGE is reported to be involved in various inflammatory disorders; however, studies that address the role of RAGE in allergic airway disease are inconclusive. RAGE-sufficient (RAGE+/+) and RAGE-deficient (RAGE−/−) mice were sensitized to ovalbumin, and airway responses were monitored after ovalbumin challenge. RAGE−/− mice showed reduced eosinophilic inflammation and ...
12 CitationsSource
#1Utako FujiiH-Index: 6
#2Arihiko KanehiroH-Index: 25
Last. Mitsune TanimotoH-Index: 68
view all 12 authors...
Source
#1Satoshi Akao (Okayama University)
#2Hideharu Hagiya (Okayama University)H-Index: 3
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 10 authors...
Source
#1Koichi Waseda (Okayama University)H-Index: 9
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Arihiko KanehiroH-Index: 25
view all 12 authors...
Pulmonary emphysema is characterized by persistent inflammation and progressive alveolar destruction. The receptor for advanced glycation end-products (RAGE) is a multiligand cell surface receptor reported to be involved in the process of acute alveolar epithelial cell injury. However, studies that address the role of RAGE in pulmonary emphysema are inconclusive. We investigated the role of RAGE in the development of elastase-induced pulmonary inflammation and emphysema in mice. RAGE-sufficient ...
16 CitationsSource