Gerd Bobe
Oregon State University
CancerInternal medicineEndocrinologyAnimal scienceOdds ratioChemistryImmunologyIce calvingColorectal adenomaInflammationAdenomaVitamin EAzoxymethaneXanthohumolPolyp Prevention TrialFood scienceColorectal cancerSeleniumMedicineBiologyImmune systemGastroenterology
139Publications
27H-index
1,764Citations
Publications 140
Newest
We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN), attenuates high-fat diet (HFD)-induced obesity and metabolic syndrome in C57Bl/6J mice. The objective of the current study was to determine the effect of XN and TXN on lipid accumulation in the liver. Non-supplemented mice were unable to adapt their caloric intake to 60% HFD, resulting in obesity and hepatic steatosis; however, TXN reduced weight gain and decreased hepatic steatosis. Liver transcriptomics ...
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#1Jacob Raber (OSU: Oregon State University)H-Index: 57
#1Jacob Raber (OSU: Oregon State University)H-Index: 2
Last. Glen E. Kisby (College of Osteopathic Medicine of the Pacific)H-Index: 22
view all 23 authors...
Background: Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysre...
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#1Yang Zhang (OSU: Oregon State University)H-Index: 4
#2Gerd Bobe (OSU: Oregon State University)H-Index: 27
Last. Thomas J. Sharpton (OSU: Oregon State University)H-Index: 27
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#1D. Elizabeth Le (OHSU: Oregon Health & Science University)H-Index: 2
#1D. Elizabeth LeH-Index: 6
Last. Sanjiv KaulH-Index: 95
view all 11 authors...
Background: While oxylipins have been linked to coronary artery disease (CAD), little is known about their diagnostic and prognostic potential. Objective: We tested whether plasma concentration of specific oxylipins may discriminate among number of diseased coronary arteries and predict median 5-year outcomes in symptomatic adults. Methods: Using a combination of high-performance liquid chromatography (HPLC) and quantitative tandem mass spectrometry, we conducted a targeted analysis of 39 oxylip...
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#1Guojie Wang (OSU: Oregon State University)
#2Gerd Bobe (OSU: Oregon State University)H-Index: 27
Last. Jean A. Hall (OSU: Oregon State University)H-Index: 24
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Abstract Selenium (Se) concentrations in soils and plants are low in the Pacific Northwest, and consequently, in livestock consuming locally-grown forages. Applying sodium selenate with traditional nitrogen-phosphorus-potassium-sulfur (NPKS) fertilizers provides a cost-effective Se agronomic biofortification method for increasing forage Se concentrations and maintaining optimum health and productivity of livestock. This 2-year study was conducted across Oregon on four representative forage field...
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The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid (BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH). This study aimed to evaluate the effects of xanthohumol (XN), a hop-derived compound mitigating metabolic syndrome, on liver damage induced by diet and FXR deficiency in mice. Wild-type (WT) and liver-specific FXR-null mice (FXRLiver-/-) were fed a high-...
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#1Yang Zhang (OSU: Oregon State University)H-Index: 4
#2Gerd Bobe (OSU: Oregon State University)H-Index: 27
Last. Adrian F. Gombart (OSU: Oregon State University)H-Index: 49
view all 13 authors...
We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN) attenuates high-fat diet (HFD) induced obesity and metabolic syndrome in C57BL/6J mice. The objective of the current study was to determine the effect of XN and TXN on lipid accumulation in the liver. Non-supplemented mice were unable to adapt their caloric intake to 60% HFD, resulting in obesity and hepatic steatosis; however, TXN reduced weight gain and decreased hepatic steatosis. Liver transcriptomics i...
Source
#1Yang Zhang (OSU: Oregon State University)H-Index: 4
#2Gerd Bobe (OSU: Oregon State University)H-Index: 27
Last. Adrian F. Gombart (OSU: Oregon State University)H-Index: 49
view all 13 authors...
We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN) attenuates high-fat diet (HFD) induced obesity and metabolic syndrome in C57BL/6J mice. The objective of the current study was to determine the effect of XN and TXN on lipid accumulation in the liver. Non-supplemented mice were unable to adapt their caloric intake to 60% HFD, resulting in obesity and hepatic steatosis; however, TXN reduced weight gain and decreased hepatic steatosis. Liver transcriptomics i...
Source
#1Lieu Tran (OSU: Oregon State University)H-Index: 1
#2Gerd Bobe (Linus Pauling Institute)H-Index: 27
Last. Yumie Takata (OSU: Oregon State University)H-Index: 5
view all 7 authors...
Peroxisome proliferator-activated receptor-γ2 gene Pro12Ala allele polymorphism (PPARG2 Pro12Ala; rs1801282) has been linked to both cancer risk and dietary factors. We conducted the first systematic literature review of studies published before December 2020 using the PubMed database to summarize the current evidence on whether dietary factors for cancer may differ by individuals carrying C (common) and/or G (minor) alleles of the PPARG2 Pro12Ala allele polymorphism. The inclusion criteria were...
1 CitationsSource
#1Maret G. Traber (OSU: Oregon State University)H-Index: 89
#2Scott W. Leonard (Linus Pauling Institute)H-Index: 32
Last. Mark Levine (NIH: National Institutes of Health)H-Index: 134
view all 9 authors...
BACKGROUND Human vitamin E (α-tocopherol) catabolism is a mechanism for regulating whole-body α-tocopherol. OBJECTIVES To determine the roles of the intestine and liver on α-tocopherol catabolism as affected by fat or fasting, 2 deuterium-labeled (intravenous d6- and oral d3-) forms of α-tocopherol were used. METHODS Healthy women received intravenous d6-α-tocopherol and consumed d3-α-tocopherol with a 600-kcal defined liquid meal (DLM; 40% or 0% fat, n = 10) followed by controlled meals; or the...
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